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[Abstract Title]. - Society for Neuroscience

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Poster<br />

232. Developmental Cell Death: Biological Effects<br />

Time: Sunday, November 16, 2008, 1:00 pm - 5:00 pm<br />

Program#/Poster#: 232.3/B43<br />

<strong>Abstract</strong>: Withdrawn<br />

Poster<br />

232. Developmental Cell Death: Biological Effects<br />

Time: Sunday, November 16, 2008, 1:00 pm - 5:00 pm<br />

Program#/Poster#: 232.4/B44<br />

Topic: A.06.a. Developmental cell death: Biological effects<br />

Support: NIH/NICHD<br />

FDA/NCTR E-7189<br />

ORISE<br />

NTP/NIEHS<br />

<strong>Title</strong>: Genotoxicity of ketamine and potential protection by midazolam in neonatal monkey<br />

cerebral cortical culture<br />

Authors: *X. ZOU 1 , N. SADOVOVA 2 , T. PATTERSON 1 , B. DIVINE 2 , M. PAULE 2 , W.<br />

SLIKKER, WILLIAM 2 , C. WANG 2 ;<br />

1 Div. Neurotoxicol, 2 Toxicologic Pathology Associates, Natl. Cntr Toxicological Resch,<br />

Jefferson, AR<br />

<strong>Abstract</strong>: Previous data suggest that exposure of rodents to various anesthetics, including those<br />

that block NMDA glutamate receptors and those that activate GABAA receptors, triggers<br />

widespread neurodegeneration in the developing brain. In<strong>for</strong>mation on genetic damage or<br />

protection in infant monkeys after exposure to a combination of NMDA antagonists and GABAA<br />

agonists (i.e., anesthetic agents) is scarce. In this study, the alkaline single cell gel<br />

electrophoresis (Comet assay) was used to study the potential genotoxic and/or protective<br />

properties of ketamine (an NMDA antagonist) and midazolam (a GABAA agonist) in cells from

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