[Abstract Title]. - Society for Neuroscience

Topic: F.02.j. Learning and memory: Pharmacology
Support: Canadian Institutes of Health Research (CIHR)
National Alliance for Research on Schizophrenia and Depression (NARSAD)
Title: Suppressing effects of dopamine D1 and D2 receptor interaction on hippocampal synaptic
plasticity and spatial learning/memory
Authors: *E. DREMENCOV, M. ZENKO, J. HAN, X. ZHANG;
Inst. Mental Hlth. Res., Univ. Ottawa, Ottawa, ON, Canada
Abstract: Accumulating evidence suggests that the dopamine D1 and D2 receptors interact to
each other at both molecular and functional levels. We recently demonstrated that coadministration
of the D1 agonist SKF38393 and the D2 agonist quinpirole increased the firing
rate of pyramidal neurons in the piriform cortex and impaired olfactory memory, which were not
observed when SKF38393 and quinpirole were given alone (Zenko et al., SfN Meeting 2007,
P710). We show the first evidence here that co-administration of SKF38393 and quinpirole not
only blocked the in vivo induction of both long-term potentiation (LTP) and long-term
depression (LTD) in the CA1 region of the rat hippocampus, but also prominently impaired both
the requisition and retrieval of hippocampus-dependent spatial memory. When given alone,
neither SKF38393 nor quinpirole produced significant effects on the in vivo induction of LTP
and LTD in the hippocampal CA1 region, or the requisition and retrieval of spatial memory.
SKF38393, co-administered with quinpirole, failed to attenuate the firing activity of basket cells
of CA1, indicating that the suppressing effects of co-administered SKF38393 and quinpirole on
synaptic plasticity of hippocampal pyramidal neurons are not mediated by GABAergic
neurotransmission. These findings support the idea that the dopamine D1 and D2 receptor
interaction plays an important role in hippocampal synaptic plasticity and spatial learning and
memory.
Disclosures: E. Dremencov , None; M. Zenko, None; J. Han, None; X. Zhang, None.
Poster
290. Animal Cognition and Behavior: Learning and Memory: Pharmacology I
Time: Sunday, November 16, 2008, 1:00 pm - 5:00 pm
Program#/Poster#: 290.2/RR53
Topic: F.02.j. Learning and memory: Pharmacology
Support: Funded by Abbott