[Abstract Title]. - Society for Neuroscience

Disclosures: C.A. Lowry , None; K.L. Gardner, None; S.L. Lightman, None; P.M. Plotsky,
None.
Press Conferences
PC-1373. Epigenetics: How Does the Environment Influence the Brain's Genetic Program?
Time: Monday, November 17, 2008, 2:00 pm - 3:00 pm
Program#/Poster#: Poster Board Number:
Topic: E.06.e. Early life experience
Support: NIH Grant MH057014
McKnight Brain Research Foundation
NARSAD
Title: Early-life adversity and its impact on DNA Methylation patterns in the amygdala
Authors: *T. ROTH, J. SWEATT;
Dept Neurobiol, Univ. Alabama Birmingham, Birmingham, AL
Abstract: Neural mechanisms responsible for the enduring effects of childhood maltreatment on
mental health remain undefined. On a molecular level, one such mechanism may be aberrant
programming of DNA methylation, an epigenetic mechanism that represses gene expression.
Indeed, aberrant DNA methylation continues to be highlighted for its role in the etiology and
expression of several mental disorders. In this study, we addressed whether early-life adversity in
the form of caregiver abuse and neglect disrupts DNA methylation in the adolescent and adult
amygdala. To model abuse and neglect, rat neonates were exposed to a stressed caregiver 30 min
daily during the first postnatal week. Littermate controls were exposed to either a non-stressed
caregiver or remained in the home cage. Results indicate that the quality of early postnatal
experiences profoundly influences DNA methylation patterns and gene expression in the
developing and adult amygdala. Such alterations may provide a framework for enduring effects
of early stressors on mental health.
Disclosures: T. Roth , None; J. Sweatt, None.
Poster