[Abstract Title]. - Society for Neuroscience

Poster
229. Neuronal and Glial Proliferation III
Time: Sunday, November 16, 2008, 1:00 pm - 5:00 pm
Program#/Poster#: 229.1/A1
Topic: A.02.a. Proliferation
Support: Korea Science Academy R&E Program (2007)
Title: Resveratrol suppresses the proliferation of neural progenitor cells and impairs adult
hippocampal neurogenesis
Authors: J. BAEK 1 , H. BANG 1 , C. LEE 1 , N. CHOI 1 , M. PARK 2 , H. PARK 2 , J. RYU 1 , *J.
LEE 2 ;
1 Korea Sci. Acad., Busan, Republic of Korea; 2 Pharm., Pusan Natl. Univ., Busan, Republic of
Korea
Abstract: Due to lack of regenerative capacity of mature neuron, impairment and damage of the
adult human central nervous system (CNS) are critical and incurable. However, the nervous
system contains populations of proliferative cells called “neural progenitor cells (NPC)” that are
capable of dividing, migrating and differentiating into neurons and glia. Thus, there is a growing
hope in the possible therapeutic potential for ischemic, traumatic, and degenerative brain
diseases. In the current study, we investigated the therapeutic potential of resveratrol in
regulating neurogenesis of NPC. Resveratrol was not effective to stimulate the proliferation of
mouse multi-potent NPC and high concentrations were even cytotoxic. We found that resveratrol
decreased the levels of phosphorylated extracellular signal regulated kinases (ERKs) which are
to be involved in the regulation of neuronal plasticity cell proliferation. Interestingly,
administration of resveratrol to adult mice resulted in a significant decrease in the number of
newly-generated cells in the dentate gyrus of hippocampus, indicating that resveratrol impairs
adult hippocampal neurogenesis. The natural polyphenol resveratrol has been shown to extend
lifespan, and offer prospect against age-related diseases such as cancer, diabetes, and
neurodegenerative diseases. However, our findings suggest that the beneficial resveratrol could
have negative effects on the proliferation of NPC, thus be harmful in developmental and adult
hippocampal neurogenesis.
Disclosures: J. Baek, None; H. Bang, None; C. Lee, None; N. Choi, None; M. Park, None; H.
Park, None; J. Ryu, None; J. Lee , None.
Poster