[Abstract Title]. - Society for Neuroscience

LCR rats were given ad libitum access to self-select from three purified macronutrient diets
(Carbohydrate, Protein, or Fat). Eighteen month old LCR rats showed substantial weight gain
over the course of the dietary self-selection intervention. In addition, LCR rats showed elevated
fasting blood-glucose levels regardless of age. To better understand the interaction between
aging and metabolism, we are also investigating additional hormonal markers of energy
management and gene-expression responses in hypothalamic energy management regions.
Disclosures: P.R. Burghardt , None; S. Britton, None; L. Koch, None; S.J. Watson,
None; H. Akil, None.
Poster
284. Regulation of Food Intake and Body Weight: Integration of Peripheral Signals:
Systems
Time: Sunday, November 16, 2008, 1:00 pm - 5:00 pm
Program#/Poster#: 284.20/QQ15
Topic: E.07.b. Integration of peripheral signals: Systems
Support: Swedish Cancer Foundation 070630
Landstinget i Östergötland
Swedish Research Council 7879
Title: Cancer-elicited anorexia is associated with induced Cox-2 expression in the brain vascular
cells and can be reversed by Cox inhibition without affecting tumor size
Authors: *J. P. RUUD 1 , W. WANG 3 , K. LUNDHOLM 3 , A. BLOMQVIST 2 ;
1 Div. of Cell Biol., 2 Clin. and Exptl. Med., Linköping, Sweden; 3 Dept. of Surgery, The Inst. of
Clin. Sci., Gothenburg, Sweden
Abstract: Several lines of evidence indicate that pro-inflammatory cytokines are involved in the
development of anorexia-cachexia, a syndrome associated with cancer and several other chronic
diseases. Because peripheral cytokines have been shown to induce prostaglandin synthesis in the
brain (Ek et al., Nature 410: 430-1, 2001), and since the deletion of prostaglandin synthesizing
enzymes abolishes cytokine-induced anorexia (Elander et al., Am J Physiol 292: R258-67, 2007),
has it been suggested that the anorexia-cachexia syndrome is prostaglandin dependent. Here we
examined the mechanisms of reduced food intake in a mouse model of cancer anorexia. A
sarcoma (MCG 101) was transplanted onto C57BL/6 mice resulting in reduced food intake,
without affecting water intake, after about 7 days. The anorexia was associated with induction of