[Abstract Title]. - Society for Neuroscience

Our results shows an increase in BrdU+ cells in the granular layer of the AOB in the pacing
group compared with the control groups. No significant differences in the number of BrdU+ cells
were found in the main olfactory bulb. These results suggest that in sexually naïve female rats
the integration of new cells in the granular layer of the AOB is necessary for processing novel
sexual stimuli. Further studies are needed to determine the type of cells that increases in the
AOB and if they are activated in the next sexual interaction.
Disclosures: R. Corona, None; R.G. Paredes , None.
Poster
229. Neuronal and Glial Proliferation III
Time: Sunday, November 16, 2008, 1:00 pm - 5:00 pm
Program#/Poster#: 229.10/A10
Topic: A.02.a. Proliferation
Support: Technology Development Program for Agriculture and Forestry, Ministry of
Agriculture and Forestry Grant 105075-3
Title: High fat diet impairs adult hippocampal neurogenesis without affecting spatial learning
and memory
Authors: *H. PARK, M. PARK, K. KONG, H. KIM, M.-S. KIM, J. LEE;
Pusan Natl. Univ., Busan, Republic of Korea
Abstract: Obesity has been progressively increasing worldwide and cause many diseases such as
diabetes, hypertension, cardiovascular diseases, dementia and cancer. One of the factors in
obesity is increased consumption of a saturated fat and sugar. High fat diet (HFD) has been
shown to be related to neurodegenerative diseases, long-term memory loss and cognitive
impairment. In addition, free fatty acid has known to induce apoptosis in differentiated PC12
cells. In the present study, we investigated the impact of HFD on the adult hippocampal
neurogenesis. Male C57/BL6 mice were divided into 2 groups, and maintained on either normal
diet (ND) or HFD. 7-weeks HFD significantly decreased in numbers of newly generated cells in
the dentate gyrus of hippocampus. Interestingly, short-term HFD (for 2 weeks) decreased the
numbers of surviving BrdU-labeled cells without altering proliferation. However, HFDmaintained
mice behaved normally, and it was not likely that HFD caused the cognitive changes
and spatial learning and memory deficit. Furthermore, we evaluated the effects of fatty acid on
neural progenitor cells (NPC). We found that free fatty acid, palmitate decreased the
proliferation of C17.2 NPCs, and was even cytotoxic. These findings suggest that HFD intake
could impair adult hippocampal neurogenesis and have negative influence on the developmental