[Abstract Title]. - Society for Neuroscience

Disclosures: M. Sharma , None; M.E. Hopkins, None; D.J. Bucci, None.
Poster
249. Dyslexia, SLI, and Other Disorders of Cognition and Behavior
Time: Sunday, November 16, 2008, 1:00 pm - 5:00 pm
Program#/Poster#: 249.21/V6
Topic: C.05.d. ADHD, SLI, dyslexia and other specific disorders of neurobehavior
Support: COFIN MIUR 2005
Title: Subchronic galactosylated dopamine desensitizes behavioral response to novelty in the
Naples High-Excitability rats
Authors: L. A. RUOCCO 1 , U. A. GIRONI CARNEVALE 1 , R. CONTE 1 , C. TRENO 1 , M.
MUROLO 1 , C. ARRA 2 , D. MELISI 3 , A. CURCIO 4 , S. DE LUCIA 5 , M. RIMOLI 4 , *A. G.
SADILE 6 ;
1 Dept Exptl Med., Second Univ. of Naples, Naples, Italy; 2 Animal Facility, Natl. Cancer Inst.
“G. Pascale” Fndn., Naples, Italy; 3 Pharmaceut. and Toxicol. Chem., Univ. “Federico II”,
Naples, Italy; 4 Pharmaceut. and Toxicol. Chem., Univ. “Federico II”, Naples, Italy; 5 Pharmaceut.
and Toxicol. Chem., Univ. of Naples “Federico II”, Naples, Italy; 6 Dept Exptl Med., Second
Univ. Naples (SUN), Naples, Italy
Abstract: Alterations of specific dopamine (DA) pathways have been connected to pathological
conditions, such as Parkinson‟s disease and Attention Deficit Hyperactivity Disorder (ADHD).
Galactosylated form of dopamine (GAL-DA) crosses the blood brain barrier and modulates
activity of mesocorticolimbic system. This, in turn, leads to reduced hyperactivity and increase
scanning time in the Naples High Excitability (NHE) rats, an animal model of the mesocortical
variant of ADHD (Neurocience, vol. 152: 234-44, 2008). Since these effects followed an acute
administration of 100 mg/kg of GAL-DA, aim of this study was to verify the plasticity of this
response. Thus, adult male NHE rats, received GAL-DA (10, 100 mg/kg or vehicle) daily for 15
days (exp 1) or 5 days (exp 2). In both cases, 3h after the last injection, rats were tested for
activity and non-selective attention in the Làt-maze. The day after, rats were injected again and 3
hours later tested in the Olton maze. In both experiments no effect was observed for indices of
activity (horizontal and vertical) or scanning duration, in both spatial novelty setups i.e. Làtmaze
and Olton maze. Moreover, in the radial maze no treatment effect was observed for number
of arm visited before first repetition occurred (FE) and number of arm visited before completion
of eight arm visit (NVTC). Besides, in the exp 1, 10 mg/kg of GAL-DA increased scanning
duration in the second part of the Làt-maze test. Therefore, subchronic GAL-DA treatment