[Abstract Title]. - Society for Neuroscience

mutations on the genes of molecules involved in CN signaling pathways. Ryanodine receptors
(RyRs) are family of intracellular calcium channels and mediate calcium-induced calcium
release (CICR) from the endoplasmic reticulum. Here we show the behavioral profile of
ryanodine receptor type3 (RyR3) knockout mice.
Disclosures: N. Matsuo, None; K. Tanda, None; N. Yamasaki, None; K. Toyama, None; S.
Ohsako, None; K. Takao, None; H. Takeshima, None; T. Miyakawa, None.
Poster
254. Schizophrenia: Mutant Animal Models
Time: Sunday, November 16, 2008, 1:00 pm - 5:00 pm
Program#/Poster#: 254.21/Y10
Topic: C.15.d. Schizophrenia: Mutant animal models
Support: Ilanna Starr Scholar Fund
Adler Foundation
NINDS RO1 NS41438 and P01 NS047308
Alzheimer‟s Association
NIA P50 AG05146
Title: BACE2 does not contribute to the schizophrenia-like endophenotypes observed in BACE1
null mice
Authors: *A. V. SAVONENKO 1 , J. W. YU 2 , T. MELNIKOVA 2 , H. D. KIM 2 , D. L. PRICE 2 , P.
C. WONG 2 ;
1 Pathol, Johns Hopkins Univ., Baltimore, MD; 2 Pathology, Johns Hopkins Univ. Med. Sch.,
Baltimore, MD
Abstract: β-site APP cleaving enzyme (BACE1) is required for the penultimate cleavage of the
amyloid-β precursor protein (APP) leading to the generation of amyloid-β peptides that is central
to the pathogenesis of Alzheimer‟s disease. In addition to APP, the identification of several other
putative BACE1 substrates strongly supports the idea that this enzyme plays multiple
physiological roles. As a developmentally regulated aspartyl protease, BACE1 participates in the
proteolytic processing of neuregulin 1 (NRG1) and influences the myelination of both central
and peripheral axons. Furthermore, NRG1 has been genetically linked to schizophrenia and