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249. Dyslexia, SLI, and Other Disorders of Cognition and Behavior Time: Sunday, November 16, 2008, 1:00 pm - 5:00 pm Program#/Poster#: 249.4/U23 Topic: C.05.d. ADHD, SLI, dyslexia and other specific disorders of neurobehavior Support: Tourette Syndrome Association Mittelstaedt family NINDS K23 NS41920 Title: Tourette syndrome blood gene expression profiles distinguish comorbid ADHD and OCD Authors: *L. LIT 1 , F. R. SHARP 2 , D. L. GILBERT 3 ; 2 Neurol. and M.I.N.D. Inst., 1 Univ. California Davis, Sacramento, CA; 3 Pediatric Neurol., Cincinnati Children‟s Hosp. Med. Ctr., Cincinnati, OH Abstract: Tourette syndrome (TS) is characterized by verbal and motor tics that occur for more than one year and are not attributed to another condition. TS is often comorbid with attention deficit hyperactive disorder (TS+ADHD), obsessive-compulsive disorder (TS+OCD) or both (TS+ADHD/OCD). Underlying dysfunctional cortico-striato-thalamo-cortical (CSTC) circuitry, affecting functionally distinct yet anatomically overlapping regions, is suspected to contribute to this comorbidity. All three disorders reflect failure to inhibit unwanted actions: motor/verbal tics (TS), repetitive behaviors (OCD), or inappropriate behaviors (ADHD). Elucidation of molecular mechanisms is needed to understand etiology and pathophysiology and develop specific treatments. Here we show that TS-only, TS+ADHD, TS+OCD, and TS+ADHD/OCD have distinct blood RNA expression profiles based upon the expression of 400-500 genes. These findings support a distinct pathophysiology and pharmacology of ADHD and OCD within TS. Moreover, the data is the first to suggest two distinct biological types of ADHD and two types of OCD. One type of ADHD and one type of OCD occur when they are co-morbid with TS alone (TS+ADHD1 or TS+OCD1); and the second types of ADHD and OCD occur when both are comorbid with TS (TS+ADHD2/OCD2). Disclosures: L. Lit , None; D.L. Gilbert, None; F.R. Sharp, None. Poster 249. Dyslexia, SLI, and Other Disorders of Cognition and Behavior Time: Sunday, November 16, 2008, 1:00 pm - 5:00 pm
Program#/Poster#: 249.5/U24 Topic: C.05.d. ADHD, SLI, dyslexia and other specific disorders of neurobehavior Support: HD 20608 Title: Embryonic methylazoxymethanol (MAM) exposure leads to rapid auditory discrimination and learning impairments in rats Authors: *S. W. THRELKELD 1 , C. A. HILL 1 , C. CLEARY 1 , G. D. ROSEN 2 , R. H. FITCH 1 ; 1 Univ. Connecticut, Storrs, CT; 2 BIDMC/Harvard Univ., Boston, MA Abstract: Developmental malformations of neocortex (microgyria, ectopia) are associated with reading impairments in humans, and with rapid auditory processing deficits in rodent models. It has further been suggested that language-based learning impairments in humans (e.g., dyslexia) could result from underlying abnormalities in auditory temporal processing. In rodent models, deficits in rapid auditory processing can be induced via disruption of cortical plate formation through genetic, epigenetic or injury-based manipulations. Interestingly, recent human clinical evidence suggests that periventricular nodular heterotopias (PNH) are also associated with poor reading skills (in the presence of normal intelligence; Chang et al., 2005). We sought to extend our rodent model by assessing the behavioral effects of PNH, induced via embryonic day (E) 15 methylazoxymethanol (MAM) treatment, on auditory processing and maze learning in rats. Male sham and MAM groups were tested with simple and complex auditory stimuli in juvenile (P22- P45) and adult (P60+) periods using a modified startle response paradigm. At the conclusion of acoustic testing, a subset of subjects was evaluated for spatial and non-spatial learning on two water maze tasks. Juvenile results showed no difference in the detection of silent gaps in white noise, indicating simple temporal processing remained intact in MAM subjects as compared to shams. However, on an oddball two-tone discrimination task, MAM subjects were significantly impaired relative to shams at detecting the stimulus reversal across interstimulus intervals (ISI) of 275 and 225 ms (p < .01). In adulthood, both groups were again tested for oddball two-tone discrimination and also an oddball FM sweep detection task. Importantly, deficits in oddball two-tone detection observed in juvenile MAM subjects were no longer seen in adulthood. However, on the novel FM sweep discrimination task, MAM subjects were significantly impaired relative to shams at detecting sweep reversals of 225, 175, 125 and 75 ms (p < .001). In addition, maze results showed a significant effect of MAM on spatial (p = .05) but not nonspatial water maze learning (MAM worse than shams). Overall results indicate significant auditory temporal processing impairments in juvenile and adult rats with E15 MAM exposure. These data show that E15 MAM exposure produces robust but selective deficits in the discrimination of complex acoustic stimuli and spatial learning, which may parallel deficits observed in human learning impaired populations. Disclosures: S.W. Threlkeld , None; C.A. Hill, None; C. Cleary, None; G.D. Rosen, None; R.H. Fitch, None.
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When citing an abstract from the 20
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229. Neuronal and Glial Proliferati
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Poster 229. Neuronal and Glial Prol
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Time: Sunday, November 16, 2008, 1:
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exaggerated when opioid receptor fu
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Our results shows an increase in Br
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the olfactory bulb and also directl
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proliferation and differentiation o
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acute administration of corticoster
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projection neurons. The large size
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surgery. Our study demonstrates tha
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coinciding with the time of light o
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hippocampus using an exhaustive ste
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Abstract: Psychological stress and
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Program#/Poster#: 230.1/A27 Topic:
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Title: FEZ1 and NDEL1 interact with
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Support: Manitoba Institute of Chil
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Support: NIH Grant NS-46616 (R01) T
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Disclosures: J.M. Han, None; M. Hir
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NIH Grant 5RO1NS031234 Title: The r
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Support: NIH grants NS23022 and NS3
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the midline. Intriguingly, MsSrc ma
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in Netrin-1 -/- and DCC-KO were mul
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located in the superficial mantle o
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addition, the pyramidal tract marke
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Authors: *L. A. TAN 1 , A. AL CHAWA
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Support: NSERC Title: Elucidating a
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Program#/Poster#: 231.6/B19 Topic:
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Topic: A.04.i. Dendritic growth and
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Searle Scholar Award Dana Program i
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Poster 231. Dendrite Growth and Bra
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NIH EY012190 OUHSC NIH EY10608 NIH
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231. Dendrite Growth and Branching:
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Title: CaMKIIδ promotes axonal and
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Poster 231. Dendrite Growth and Bra
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231. Dendrite Growth and Branching:
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Disclosures: M. Warren , None; W. B
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Poster 232. Developmental Cell Deat
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numbers of neuronal and non-neurona
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NIH Grant DA05072 NIH Grant NS05710
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Poster 232. Developmental Cell Deat
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mice were found to be significantly
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DGAPA-UNAM (IN223107) Title: Effect
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white matter, projecting in a wides
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DGAPA IN-214607-3 Title: Rotenone-i
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232. Developmental Cell Death: Biol
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cortices), only neonatal PCP treatm
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proapoptotic activity. When RGM was
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Luca et al., 1996). However, beside
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1 Dept Hyg., Kanazawa Univ. Sch. Me
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Poster 233. Nicotinic Aacetylcholin
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acetylcholine. These results sugges
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[ 3 H]epibatidine with nanomolar af
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esponses on the human alpha4/beta2
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Support: GM57481-05A2 Title: Identi
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Topic: B.02.c. Nicotinic acetylchol
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Program#/Poster#: 233.15/C17 Topic:
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Disclosures: A.J. Hone , None; Y. X
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Poster 233. Nicotinic Aacetylcholin
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Disclosures: A.P. Govind, None; H.S
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chronic effects of nicotine in vivo
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234. A-Type Potassium Channels Time
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Poster 234. A-Type Potassium Channe
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immunostaining with a marker for se
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Authors: *Z. M. KHALIQ, B. P. BEAN;
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Title: Messenger RNA and protein ex
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234. A-Type Potassium Channels Time
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Disclosures: W.C. de Groat, None; A
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potential therapeutic benefits of 1
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complex rectification of Kir4.1 cha
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Authors: *C. F. BARRETT 1 , L. A. M
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Poster 235. Ion Channels in Disease
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use a neuronal cell-type specific p
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The therapeutic index, as determine
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several components. The fast compon
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Abstract: TRPM7 channels are Ca 2+
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a shRNA knockdown approach to selec
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Alzheimer‟s disease, Parkinson‟
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Title: Electrical fusion pore measu
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large secretory vesicles.
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Title: Vesicle membrane bending ene
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Title: Transient narrow fusion pore
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Program#/Poster#: 236.7/D7 Topic: B
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molecular determinants of this vari
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Disclosures: R.E. Guzman , None; Y.
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Poster 236. Neurotransmitter Releas
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Program#/Poster#: 236.15/D15 Topic:
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Topic: B.06.a. Docking and fusion S
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Title: Regulation of levels of UNC-
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Title: Identification and character
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Grants-in-Aid for Scientific Resear
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Support: KB is a recipient of the f
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We conclude that the both excitator
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translocation. In neurons clamped a
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Variation in sensory pathways allow
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Disclosures: S. Kodama, The Ministr
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immobilization, cardiac arrest) is
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of the PFC, hippocampus and VTA to
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Program#/Poster#: 237.12/D37 Topic:
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237. Synaptic Integration II Time:
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apamin (20 nM) increased spike rate
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also dynamically arise from Cl flux
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Support: NIH Grant EY11850 HHMI Tit
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238. LTD: Hippocampus and Cortex Ti
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Disclosures: T. Ho, None; K.A. Pelk
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Poster 238. LTD: Hippocampus and Co
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Support: Ray Thomas Edwards Foundat
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Poster 238. LTD: Hippocampus and Co
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polarization assay. The screen yiel
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Abstract: Here we describe the disc
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of synaptic plasticity in the later
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initiated studies to determine whet
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compartment. Here, by application o
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from live imaging experiments of hi
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inhibition were balanced. Afterward
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Italian MIUR San Paolo Foundation M
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Poster 239. Structural Plasticity a
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Israel Science Foundation (768/06)
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Abstract: Chemical synapses serve a
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Howard Hughes Medical Institute Tit
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Abstract: Recently structural plast
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Abstract: Previous work from our la
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Program#/Poster#: 239.16/E13 Topic:
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Program#/Poster#: 239.18/E15 Topic:
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Oxidation-state-dependent interconn
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Disclosures: T.K. Karlsson , None;
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oth cell type-specific and cell typ
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identified. Indeed, some of these s
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242). No significant differences in
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Title: Alterations of Ih dynamics u
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240. Intrinsic Membrane Properties:
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Support: NIH grant AA14973 Title: E
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Poster 240. Intrinsic Membrane Prop
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evoked by synaptic stimulation, and
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Title: Activity-dependent bidirecti
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Topic: B.10.b. Modulation of neuron
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240. Intrinsic Membrane Properties:
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Disclosures: J.T. Brown, None; A.D.
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Picrotoxin). The induction protocol
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axons at DIV 18-22. Using this syst
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histochemistry, the present study f
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temporal and spatial expression of
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Authors: M. TOSIC 1 , I. ALLAMAN 2
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OGS CIHR Title: Brain-specific cros
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Authors: *N. D. AMIN 1 , Y. ZHENG 1
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Support: MA 037 Title: Process form
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Title: Plp gene mutation results in
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paranodal, ECM, and axonal cytoskel
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sensitive dye Fura-2 were loaded in
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survival and specification to a TuJ
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immunohistochemisty revealed that t
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microchannels into the axon/glia co
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Hippocampal astrocytes were electro
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Authors: *G. PEREA, A. ARAQUE; Dept
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Program#/Poster#: 242.5/H12 Topic:
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242. Glial Neuronal Interactions: G
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242. Glial Neuronal Interactions: G
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CAM-CSIC (200620M083) European Unio
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NS059028 DE018573 NS060735 Title: A
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Program#/Poster#: 242.17/I12 Topic:
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stimuli, but is potentiated by sust
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Poster 242. Glial Neuronal Interact
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key parameters involved using a sen
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Abstract: Alzheimer‟s disease (AD
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The Children‟s Foundation for Sle
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NIH Grant NS43946 NIH Grant AG 0274
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pGluAbeta(3-42). The isolated regul
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modulates neuronal function and syn
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Authors: N. NEMIEBOKA 1 , S. THOMAS
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243. Abeta Assembly and Deposition
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is comparable to those in APP/Abca1
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event in the aggregation of Aβ42.
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3 Dept Psychiat & Pharmacol, Vander
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Poster 244. Abeta Toxicity I Time:
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SY5Y and SH-SY5Y/pEGFP-LC3 cells. O
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CA1. For evaluation of cell surviva
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Aβ(1-42) in water (100 κM) did no
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in either dentate gyrus or CA field
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the α-secretase product (s-APP-α)
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Support: National Health and Medica
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diminished Aβ immunofluorescence i
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A Grant-in-aid for Promotion of Sci
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Program#/Poster#: 245.2/N8 Topic: C
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Aβ immunotherapy in uninjured 3xTg
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Authors: *Q.-L. MA, O. J. UBEDA, W.
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overlay assays. Caspase activation
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expressed in the hippocampal format
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Tau mice as compared with P301L Tau
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Dab1 by Cre-mediated recombination
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neuroprotective effects could arise
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process of neurite outgrowth. Tau f
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common dementia among older people
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Program#/Poster#: 245.22/P4 Topic:
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Methods: Data from the WBDS was col
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Topic: C.01.o. Imaging and biomarke
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Poster 246. Alzheimer's Imaging and
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somatodendritic distribution. A ser
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neurodegenerative syndromes, little
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compared to the controls. After con
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invasive in vivo magnetic resonance
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Poster 246. Alzheimer's Imaging and
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Disclosures: N.C. Berchtold , None;
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fusiform gyrus, and Brodmann area 1
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Authors: *S. KIM, K. CHOI, J. HA, J
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zonisamide 1) elevates the brain co
Page 437 and 438: Abstract: Ghrelin targets the hypot
Page 439 and 440: Program#/Poster#: 247.7/S2 Topic: C
Page 441 and 442: neuroprotective mechanism, further
Page 443 and 444: and two-dimensional electrophoretic
Page 445 and 446: Abstract: The present study was des
Page 447 and 448: Title: Effect of tissue capacitance
Page 449 and 450: Poster 247. Parkinson's Disease Int
Page 451 and 452: hyperactivity during the task and f
Page 453 and 454: effects on dopaminergic neurons in
Page 455 and 456: Support: 2005-2006 American Foundat
Page 457 and 458: support the idea that RAS may encou
Page 459 and 460: contrast, pramipexole and pergolide
Page 461 and 462: Unilateral intrastriatal injection
Page 463 and 464: Title: L-DOPA-induced dyskinesia in
Page 465 and 466: Program#/Poster#: 248.2/U1 Topic: C
Page 467 and 468: Topic: C.03.j. Dystonia Support: Gr
Page 469 and 470: Poster 248. Dystonia Time: Sunday,
Page 471 and 472: Poster 248. Dystonia Time: Sunday,
Page 473 and 474: disulfide-bonds in torsinA(ΓE) oli
Page 475 and 476: protein kinase C (PKC) activation.
Page 477 and 478: often exhibits diverse psychiatric
Page 479 and 480: training between the groups. Partic
Page 481 and 482: abnormal postures. It is often hypo
Page 483 and 484: Support: Deutsche Forschungsgemeins
Page 485 and 486: Title: Effects of early exposure to
Page 487: Support: HD 20608 Title: Assessment
Page 491 and 492: short silent gap), as well as in pr
Page 493 and 494: Abstract: We have previously report
Page 495 and 496: Do Rio Grande do Sul, Porto Alegre,
Page 497 and 498: Poster 249. Dyslexia, SLI, and Othe
Page 499 and 500: with the behavioral deficit, spine
Page 501 and 502: 50-60% decrease of both parvalbumin
Page 503 and 504: morphine, nicotine, caffeine, chron
Page 505 and 506: and NRB rats were given a daily i.p
Page 507 and 508: Poster 249. Dyslexia, SLI, and Othe
Page 509 and 510: appears to desensitises response to
Page 511 and 512: Title: The neurobiological profile
Page 513 and 514: epresentation is superior to the re
Page 515 and 516: sensory and motor cortex during spe
Page 517 and 518: Abstract: Temporal lobe epilepsy is
Page 519 and 520: Authors: *X. E. NDODO-EKANE, J. NIS
Page 521 and 522: Topic: C.06.h. In vivo mechanisms T
Page 523 and 524: 250. Epilepsy: Networks Time: Sunda
Page 525 and 526: permanent redistribution of hippoca
Page 527 and 528: Authors: *T. J. KISPERSKY 1 , J. A.
Page 529 and 530: Topic: C.06.f. Circuits and systems
Page 531 and 532: Poster 250. Epilepsy: Networks Time
Page 533 and 534: esults pinpoint the combined intera
Page 535 and 536: Anaesthesiology and Intensive Care,
Page 537 and 538: with altered performance of tasks r
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Title: Oligodendrocytes form couple
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Support: B. Deverman is supported b
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Poster 251. Demyelinating Disorders
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mice lacking the β3 subunit of VGC
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ostral CC, while myelinated or demy
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Disclosures: K.J. Garofalo , None;
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autoimmune diseases, including mult
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Authors: *M. CORTÉS 1 , M. L. ITA
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National Multiple Sclerosis Society
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Disclosures: F.L. Robinson, None; I
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wks (acute CC demyelination) or 12
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nodes were collected at different p
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in the anti-inflammatory cytokines.
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Poster 251. Demyelinating Disorders
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interest, since MBP is thought to b
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Functional studies showed that HBMV
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CD14 and the cytoskeleton proteins
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Abstract: Multiple sclerosis (MS) i
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alance and cognitive changes which
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252. Demyelinating Disorders: Mecha
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glutamate release and postsynaptica
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Aging, LKS Fac. of Med., 4 State Ke
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Abstract: Mitochondrial dynamics (f
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Title: Rotenone reduces Mg2+-depend
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Poster 253. Parkinson's Disease Mod
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striatum respectively, and another
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Authors: J. SHIM 1 , H. KIM 1 , M.
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of the Substantia Nigra (SN) and th
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Program#/Poster#: 254.1/X18 Topic:
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pathology, we compared the expressi
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understood. Glutamate receptor sign
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Authors: *N. N. NEW 1,2 , J. D. JEN
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Poster 254. Schizophrenia: Mutant A
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Topic: C.15.d. Schizophrenia: Mutan
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254. Schizophrenia: Mutant Animal M
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mutations on the genes of molecules
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medications. A genome-wide associat
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ehavioral sensitization. Behavioral
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including muscarinic, serotonergic
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Authors: *L. B. RESSTEL, F. M. A. C
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Title: Mechanisms of the antidepres
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Support: CAPES FAPESP CNPq Title: F
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255. Mood Disorders: Animal Models
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the prefrontal cortex, amygdala, lo
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This abstract has been authored by
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propagating depressive-like behavio
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suffer from panic disorder. The CCK
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255. Mood Disorders: Animal Models
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Poster 255. Mood Disorders: Animal
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decreased social interaction, indic
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previously identified 17 genes with
Page 649 and 650:
Title: Modulatory effects of comorb
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with anxious temperament in the BNS
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Authors: *S. E. FAHNHORST 1 , M. A.
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256. Anxiety Disorders: Human Bioma
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256. Anxiety Disorders: Human Bioma
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Title: Regulation of human serotoni
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Topic: C.15.l. Other Title: Differe
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Poster 257. Alcohol Intake and Pref
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Poster 257. Alcohol Intake and Pref
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Disclosures: C.E. Schnell, None; R.
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in life. Future studies should not
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co-variation in alcohol and sweet i
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Title: Ethanol binge drinking incre
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Page 677 and 678:
Authors: *O. RICE 1 , M. KRANTZ 2 ,
Page 679 and 680:
P rats provided by the Indiana Alco
Page 681 and 682:
Disclosures: M. Job, None; R.A. Gon
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Poster 258. Molecular and Neurochem
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contemporary stereology. HR but not
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infusions (0.03 mg/kg/infusion) but
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to assess changes in gene transcrip
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Abstract: Nicotine dependence is ma
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Topic: C.16.k. Nicotine Support: Ac
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present study demonstrate that expo
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Abstract: It is widely accepted tha
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Topic: C.16.k. Nicotine Title: Acti
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spiking and the bursts. These resul
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nicotine SA training (0.03 mg/kg/in
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Abstract: Nicotinic acetylcholine r
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vertebrate groups acquired sensitiv
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Authors: M. MIRJANY, *D. S. FABER;
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Support: NIH R01 DC00092 NIH 5T32GM
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Topic: D.02.a. Mechanoreceptors and
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Disclosures: B.N. Buran, None; N. S
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examine potential cell cycle re-ent
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Authors: *R. D. FRISINA 1,2 , S. F.
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Poster 259. Cochlear Mechanorecepto
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compact parametric point process me
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Ungerleider, 1989; Ungerleider and
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260. Objects and Faces in Humans II
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BOLD signal time courses for the fo
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ecognition might depend on represen
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Title: A Bayesian decoder that reco
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Title: Building vision: Splitting t
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Title: Beamforming event-related fi
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Topic: D.04.j. Processing of object
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about non-preferred objects. We tes
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intact. This suggests that the FFA
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Authors: *C. S. KONEN 1,2 , M. A. P
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Title: Simultaneous LFP recordings
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Program#/Poster#: 261.6/CC3 Topic:
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Additionally, the degree of adaptat
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Abstract: Electrophysiological reco
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the temporal visual cortex of monke
Page 757 and 758:
organized at the network level rema
Page 759 and 760:
trend occurred on an individual bas
Page 761 and 762:
Abstract: The sensory inputs used t
Page 763 and 764:
Abstract: In the influential Marr-A
Page 765 and 766:
Fondazione del Monte di Bologna e R
Page 767 and 768:
Poster 262. Visually-Guided Reachin
Page 769 and 770:
showed significant increases in rCB
Page 771 and 772:
was that eye position would dominat
Page 773 and 774:
Center for the Neural Basis of Cogn
Page 775 and 776:
Poster 262. Visually-Guided Reachin
Page 777 and 778:
upper to lower (U-L) position or fr
Page 779 and 780:
standard visuomotor transformations
Page 781 and 782:
DC; 4 District Amputee Care, Washin
Page 783 and 784:
Disclosures: J.N. Van Der Geest, No
Page 785 and 786:
correlated (r=+0.59). In contrast,
Page 787 and 788:
of cMRF reticulotectal axonal termi
Page 789 and 790:
Topic: D.06.c. Eye and head control
Page 791 and 792:
movement. A more complete analysis
Page 793 and 794:
and movement in alert, head-unrestr
Page 795 and 796:
FNRS (Belgium), ESA (EU) Title: Com
Page 797 and 798:
Poster 263. Eye Movements: Eye and
Page 799 and 800:
Topic: D.06.c. Eye and head control
Page 801 and 802:
Poster 263. Eye Movements: Eye and
Page 803 and 804:
neural learning was directly correl
Page 805 and 806:
Abstract: Previously we demonstrate
Page 807 and 808:
Abstract: Several structures in the
Page 809 and 810:
Authors: *S. P. MAHAFFY 1,2 , R. J.
Page 811 and 812:
Topic: D.06.d. Saccades and Pursuit
Page 813 and 814:
Support: DFG SFB 509 Title: Develop
Page 815 and 816:
Page 817 and 818:
trial causes impressive pursuit lea
Page 819 and 820:
orientation was determined from spa
Page 821 and 822:
Abstract: When generating saccades
Page 823 and 824:
Abstract: Cold temperatures are kno
Page 825 and 826:
healthy. These mice were subjected
Page 827 and 828:
Abstract: Peripheral anti-hyperalge
Page 829 and 830:
Title: Transient receptor potential
Page 831 and 832:
stably expressing trkA receptors we
Page 833 and 834:
and decrease in response threshold
Page 835 and 836:
The results demonstrate that 1) TRP
Page 837 and 838:
treatment with estradiol increases
Page 839 and 840:
Topic: D.08.a. Pain transduction mo
Page 841 and 842:
have agonist properties at selectiv
Page 843 and 844:
Abstract: Electrical stimulation ca
Page 845 and 846:
p
Page 847 and 848:
(2006) exhibited lower pain ratings
Page 849 and 850:
and controls, the lowest pain thres
Page 851 and 852:
numeric rating scale (0 - 10). Palm
Page 853 and 854:
Abstract: Capsaicin-desensitization
Page 855 and 856:
Topic: D.08.h. Psychophysics and be
Page 857 and 858:
Disclosures: C. Cosi, None; V. Carl
Page 859 and 860:
ackward translation by a translator
Page 861 and 862:
Abstract: Chronic pain is detriment
Page 863 and 864:
Title: Expression of c-Fos in a rod
Page 865 and 866:
267. Pain: Pain Models II Time: Sun
Page 867 and 868:
head withdrawal to application of v
Page 869 and 870:
Authors: A. A. CHERRO 1 , *H. MARSH
Page 871 and 872:
Support: DFG KFO 107 Kompetenzzentr
Page 873 and 874:
Poster 267. Pain: Pain Models II Ti
Page 875 and 876:
267. Pain: Pain Models II Time: Sun
Page 877 and 878:
functional metabolic impairment ame
Page 879 and 880:
pain had been induced. Respiratory
Page 881 and 882:
mechanical stimulation, and tail wi
Page 883 and 884:
periods of prolonged thermal nocice
Page 885 and 886:
we examined whether the functional
Page 887 and 888:
Authors: *W. A. ECKERT, M. MAHER, D
Page 889 and 890:
Topic: D.08.l. Neuropathic pain: Me
Page 891 and 892:
Program#/Poster#: 268.8/GG5 Topic:
Page 893 and 894:
268. Neuropathic Pain Mechanisms: I
Page 895 and 896:
as non-nociceptive (LTM) or nocicep
Page 897 and 898:
Topic: D.08.l. Neuropathic pain: Me
Page 899 and 900:
and tolbutamide blocked NPo, withou
Page 901 and 902:
understood. The cytokine GRO/KC (gr
Page 903 and 904:
Frey filament with strength of 0.68
Page 905 and 906:
glutamate transporter EAAT2 is the
Page 907 and 908:
GlaxoSmithKline (CASE studentship)
Page 909 and 910:
Poster 269. Pain: Visceral Pain II
Page 911 and 912:
269. Pain: Visceral Pain II Time: S
Page 913 and 914:
Title: Responses of T3 spinal neuro
Page 915 and 916:
Page 917 and 918:
Page 919 and 920:
inhibition for both peptides) in NO
Page 921 and 922:
induced by intracolonic injection o
Page 923 and 924:
Authors: *B. C. YOBURN 1 , S. V. DI
Page 925 and 926:
Abstract: Forced swim produces a de
Page 927 and 928:
increase in expression of CGRP in s
Page 929 and 930:
injections of morphine (15 ug) at 9
Page 931 and 932:
Authors: A. CARRASCO, M. J. LEE, *J
Page 933 and 934:
270. Pain: Opioids and Other Analge
Page 935 and 936:
Alkermes, Inc., A. Employment (full
Page 937 and 938:
Disclosures: N.M. Wilson , None; F.
Page 939 and 940:
(nitric oxide and inflammatory cyto
Page 941 and 942:
MH45361 Title: Increase in antinoci
Page 943 and 944:
Page 945 and 946:
Poster 271. Mechanoreceptors Time:
Page 947 and 948:
endings, never in their axons. In e
Page 949 and 950:
The neurite's cell body resides in
Page 951 and 952:
Support: AFOSR MURI Biologically In
Page 953 and 954:
Page 955 and 956:
Support: NIH MBRS-SCORE grant 1s06G
Page 957 and 958:
CRF than controls. The feeling of e
Page 959 and 960:
whether the increased activation wa
Page 961 and 962:
Support: NIH 1R15NS053442-01A1 NIH
Page 963 and 964:
Poster 272. Kinematics and EMG: Dis
Page 965 and 966:
Disclosures: J.L. Alberts, None; A.
Page 967 and 968:
Adaptation, step lengths initially
Page 969 and 970:
of 65 age-matched control subjects
Page 971 and 972:
CSN Title: Motor patterns typical o
Page 973 and 974:
Abstract: The primate basal ganglia
Page 975 and 976:
Topic: D.15.a. Transmitters and neu
Page 977 and 978:
Disclosures: M.A. de Souza Silva, N
Page 979 and 980:
or the specific NMDA receptor antag
Page 981 and 982:
Psychological and Brain Sci., Johns
Page 983 and 984:
Supported by Cinvestav and Conacyt
Page 985 and 986:
Topic: D.15.a. Transmitters and neu
Page 987 and 988:
induction protocol does not result
Page 989 and 990:
peristimulus time histograms of dop
Page 991 and 992:
Authors: *S. GEISLER, R. A. WISE; B
Page 993 and 994:
Support: CONACyT 50427Q Title: Dopa
Page 995 and 996:
Poster 274. Basal Ganglia: Transmit
Page 997 and 998:
efficacy as a A2A antagonist and as
Page 999 and 1000:
Support: BFI2003-02909 Ramón y Caj
Page 1001 and 1002:
Poster 274. Basal Ganglia: Transmit
Page 1003 and 1004:
observed that adenosine A1 receptor
Page 1005 and 1006:
Authors: *E. JUNG 1 , D.-S. KIM 2 ,
Page 1007 and 1008:
Abstract: Anticipatory postural adj
Page 1009 and 1010:
Poster 275. Posture: Kinematics and
Page 1011 and 1012:
motion captured by a 6-camera Vicon
Page 1013 and 1014:
with the head a linearly actuated p
Page 1015 and 1016:
of the human lower limb for standin
Page 1017 and 1018:
Abstract: Introduction. Studies on
Page 1019 and 1020:
Topic: D.16.d. Kinematics and Muscl
Page 1021 and 1022:
Poster 275. Posture: Kinematics and
Page 1023 and 1024:
data of the head and whole body wer
Page 1025 and 1026:
Program#/Poster#: 275.17/JJ32 Topic
Page 1027 and 1028:
to low targets. Although reach perf
Page 1029 and 1030:
Abstract: Patients with Parkinson
Page 1031 and 1032:
Program#/Poster#: 275.22/KK3 Topic:
Page 1033 and 1034:
was maintained, but aging resulted
Page 1035 and 1036:
standard clinical measures for bala
Page 1037 and 1038:
Program#/Poster#: 275.27/KK8 Topic:
Page 1039 and 1040:
275. Posture: Kinematics and Muscle
Page 1041 and 1042:
Poster 276. Voluntary Movement: Str
Page 1043 and 1044:
Abstract: Previous studies have sug
Page 1045 and 1046:
Support: NIH Grant R01-NS052509 Tit
Page 1047 and 1048:
Poster 276. Voluntary Movement: Str
Page 1049 and 1050:
significantly change. Reaching time
Page 1051 and 1052:
Abstract: [Objective] The purpose o
Page 1053 and 1054:
Stanford University Department of N
Page 1055 and 1056:
novel approach to exploring the rel
Page 1057 and 1058:
Abstract: The contribution of the c
Page 1059 and 1060:
277. Voluntary Movement: Cortical P
Page 1061 and 1062:
Poster 277. Voluntary Movement: Cor
Page 1063 and 1064:
Abstract: Slow finger movements in
Page 1065 and 1066:
Topic: D.17.b. Cortical planning an
Page 1067 and 1068:
Page 1069 and 1070:
simulate the conditions of active m
Page 1071 and 1072:
Title: Primary motor cortex reflect
Page 1073 and 1074:
Topic: D.17.b. Cortical planning an
Page 1075 and 1076:
unperturbed reaching movements (bas
Page 1077 and 1078:
Authors: *S. BESTMANN 1 , M. MUNNEK
Page 1079 and 1080:
elements are also part of a squirre
Page 1081 and 1082:
15, 30, and 60κA. The stimulus fre
Page 1083 and 1084:
Authors: *D. M. GRIFFIN 1 , H. M. H
Page 1085 and 1086:
Page 1087 and 1088:
Page 1089 and 1090:
dynamics which is not substantially
Page 1091 and 1092:
uncorrected) during compatible tria
Page 1093 and 1094:
Poster 278. Sex Differences I Time:
Page 1095 and 1096:
Disclosures: L.M. Tejada , None; E.
Page 1097 and 1098:
distribution of ER-containing neuro
Page 1099 and 1100:
Support: NIH grant RO1 NS055218 Tit
Page 1101 and 1102:
Page 1103 and 1104:
Disclosures: B.M. Nugent, None; J.M
Page 1105 and 1106:
Page 1107 and 1108:
Program#/Poster#: 278.16/MM9 Topic:
Page 1109 and 1110:
Canada Foundation for Innovation Mi
Page 1111 and 1112:
Topic: E.01.d. Development Support:
Page 1113 and 1114:
Program#/Poster#: 279.1/MM15 Topic:
Page 1115 and 1116:
279. Steroids and Plasticity I Time
Page 1117 and 1118:
Support: NS07080 Title: Acute and s
Page 1119 and 1120:
Poster 279. Steroids and Plasticity
Page 1121 and 1122:
activation on principal cell dendri
Page 1123 and 1124:
castration to deplete circulating t
Page 1125 and 1126:
hippocampus are major targets of st
Page 1127 and 1128:
NINDS Grant NS48141 Title: Using mi
Page 1129 and 1130:
Poster 279. Steroids and Plasticity
Page 1131 and 1132:
NIH grant HD18185 NIH grant MH62677
Page 1133 and 1134:
hippocampus (p
Page 1135 and 1136:
corticosterone, brain monoamine uti
Page 1137 and 1138:
Support: NSF grant 0549987 to TD HD
Page 1139 and 1140:
Page 1141 and 1142:
suggested that dominant and submiss
Page 1143 and 1144:
cancer increases the prevalence of
Page 1145 and 1146:
Poster 280. Stress and the Brain: S
Page 1147 and 1148:
Poster 280. Stress and the Brain: S
Page 1149 and 1150:
augmented maternal care is converte
Page 1151 and 1152:
Authors: *A. S. IVY 1 , K. L. BRUNS
Page 1153 and 1154:
Topic: E.06.e. Early life experienc
Page 1155 and 1156:
281. Stress and the Brain: Early Li
Page 1157 and 1158:
Telethon Grant GGP05220, Italy Titl
Page 1159 and 1160:
Title: Early-life stress is associa
Page 1161 and 1162:
Topic: E.06.e. Early life experienc
Page 1163 and 1164:
Page 1165 and 1166:
aversion, further research is neede
Page 1167 and 1168:
than the controls (p
Page 1169 and 1170:
compared to unstressed controls. Si
Page 1171 and 1172:
Title: Maternal deprivation affects
Page 1173 and 1174:
Disclosures: N. Lajud, None; L. Tor
Page 1175 and 1176:
SNB motoneuron development. In addi
Page 1177 and 1178:
autonomic control in juvenile (i.e.
Page 1179 and 1180:
known to be susceptible to hypoxic
Page 1181 and 1182:
stress-related psychiatric disorder
Page 1183 and 1184:
Page 1185 and 1186:
and found that there was a greater
Page 1187 and 1188:
and cognition in the adult brain. T
Page 1189 and 1190:
10:137-143). Here, microarray profi
Page 1191 and 1192:
MH 38273 HD 05751 Title: Corticotro
Page 1193 and 1194:
Authors: *B. N. SRIKUMAR, V. PRIYA,
Page 1195 and 1196:
Authors: *K. J. LEE 1 , H.-J. KIM 1
Page 1197 and 1198:
Program#/Poster#: 282.18/OO25 Topic
Page 1199 and 1200:
Program#/Poster#: 282.20/OO27 Topic
Page 1201 and 1202:
Page 1203 and 1204:
Poster 283. Stress-Regulated Pathwa
Page 1205 and 1206:
the post-fatigue scan, the fatigue
Page 1207 and 1208:
show a higher prevalence in females
Page 1209 and 1210:
i.v. sodium lactate. Recently, we r
Page 1211 and 1212:
Support: MRC Project Grant (UK) Mar
Page 1213 and 1214:
Program#/Poster#: 283.10/PP6 Topic:
Page 1215 and 1216:
52619, B. Research Grant (principal
Page 1217 and 1218:
priming experiments (daily bilatera
Page 1219 and 1220:
Disclosures: I. Bantounas, None; Y.
Page 1221 and 1222:
ut the biological role and tissue d
Page 1223 and 1224:
Title: Altered wiring of emotional-
Page 1225 and 1226:
Topic: E.06.f. Stress modulated pat
Page 1227 and 1228:
Poster 283. Stress-Regulated Pathwa
Page 1229 and 1230:
group received 6-hour daily restrai
Page 1231 and 1232:
embryonic and early postnatal perio
Page 1233 and 1234:
stressed vs. unstressed rats. In pa
Page 1235 and 1236:
Page 1237 and 1238:
Poster 284. Regulation of Food Inta
Page 1239 and 1240:
functional assays, respectively and
Page 1241 and 1242:
284. Regulation of Food Intake and
Page 1243 and 1244:
neurons respond to metabolic and se
Page 1245 and 1246:
to evaluate the validity of the ass
Page 1247 and 1248:
NIH Grant RR021945 Title: Innervati
Page 1249 and 1250:
Research Foundation (JDRF), C. Othe
Page 1251 and 1252:
vago-vagal reflexes suggest that no
Page 1253 and 1254:
neurons that are defined by their e
Page 1255 and 1256:
LCR rats were given ad libitum acce
Page 1257 and 1258:
day 20 to 40 (restricted-running),
Page 1259 and 1260:
HL60296 MH63323 Title: Sleep-relate
Page 1261 and 1262:
285. Sleep: Molecular, Cellular and
Page 1263 and 1264:
whether focal rescue of orexin rece
Page 1265 and 1266:
Program#/Poster#: 285.7/QQ23 Topic:
Page 1267 and 1268:
Poster 285. Sleep: Molecular, Cellu
Page 1269 and 1270:
References: 1. S. M. Reppert, D. R.
Page 1271 and 1272:
Title: T-type (Ca[V]3) calcium chan
Page 1273 and 1274:
explanation for the increased sleep
Page 1275 and 1276:
Title: In C57BL/6J (B6) mouse the G
Page 1277 and 1278:
Baghdoyan, Sepracor, B. Research Gr
Page 1279 and 1280:
immobilisation stress in 5-HTT-/- m
Page 1281 and 1282:
Authors: C.-L. LIANG 1 , *G. A. MAR
Page 1283 and 1284:
Support: NIMH (P20 MH077967) NIH Di
Page 1285 and 1286:
Poster 285. Sleep: Molecular, Cellu
Page 1287 and 1288:
as a reference since „barrel' AF
Page 1289 and 1290:
Authors: I. C. TENG 1 , P. TIAN 1 ,
Page 1291 and 1292:
Support: NIH Grant NS-051188 NIH Gr
Page 1293 and 1294:
Poster 286. Imaging the Nervous Sys
Page 1295 and 1296:
esponses were observed to those mea
Page 1297 and 1298:
CYP450 epoxygenase and inward recti
Page 1299 and 1300:
Title: Discovery of a neuronal popu
Page 1301 and 1302:
hemodynamic response. Further, diff
Page 1303 and 1304:
Disclosures: V. Manda , None; R.K.
Page 1305 and 1306:
membrane. This represents the first
Page 1307 and 1308:
to wide-band noise at the level of
Page 1309 and 1310:
transmission electron microscopy (T
Page 1311 and 1312:
Program#/Poster#: 287.9/RR3 Topic:
Page 1313 and 1314:
Authors: *K. DEVRAJ 1 , A. MOKASHI
Page 1315 and 1316:
arranged in three clusters (Pcdh-α
Page 1317 and 1318:
Page 1319 and 1320:
ecent but currently unavailable con
Page 1321 and 1322:
processes such as language, plannin
Page 1323 and 1324:
Topic: F.01.f. Working memory Suppo
Page 1325 and 1326:
indicated that during working memor
Page 1327 and 1328:
Executive function impairment is a
Page 1329 and 1330:
288. Working Memory: Disorders, Gen
Page 1331 and 1332:
Topic: F.01.f. Working memory Suppo
Page 1333 and 1334:
Program#/Poster#: 288.16/RR23 Topic
Page 1335 and 1336:
demonstrating how they span the dif
Page 1337 and 1338:
Abstract: Central synaptic dopamine
Page 1339 and 1340:
Title: Connectivity of the human wo
Page 1341 and 1342:
Disclosures: S. Ganguli, None; B.D.
Page 1343 and 1344:
ack and 2-back) in which they press
Page 1345 and 1346:
Authors: *M. K. VAN VUGT 1 , M. J.
Page 1347 and 1348:
Authors: *J. NG 1 , C. Y. TANG 1,2
Page 1349 and 1350:
Disclosures: E.L. Eaves, None; C.Y.
Page 1351 and 1352:
Topic: F.01.g. Decision making and
Page 1353 and 1354:
ACC projects to locus coeruleus (LC
Page 1355 and 1356:
composed of disparate red-blue sphe
Page 1357 and 1358:
which the timing of the response wa
Page 1359 and 1360:
Poster 289. Human Decision Making T
Page 1361 and 1362:
Program#/Poster#: 289.12/RR48 Topic
Page 1363 and 1364:
load or task switching, suggesting
Page 1365 and 1366:
Authors: *M. S. SCULLY 1,3 , B. AND
Page 1367 and 1368:
Title: Dopamine D3 receptor blockad
Page 1369 and 1370:
Title: NCAM signaling through the F
Page 1371 and 1372:
290. Animal Cognition and Behavior:
Page 1373 and 1374:
Authors: *E. E. BIGNEY, H. K. TAUKU
Page 1375 and 1376:
Topic: F.02.j. Learning and memory:
Page 1377 and 1378:
Poster 290. Animal Cognition and Be
Page 1379 and 1380:
290. Animal Cognition and Behavior:
Page 1381 and 1382:
Page 1383 and 1384:
Page 1385 and 1386:
evoked cholinergic signal amplitude
Page 1387 and 1388:
Abstract: Deficient sensory inhibit
Page 1389 and 1390:
1 EPHE, Univ. Montpellier II, INSER
Page 1391 and 1392:
Page 1393 and 1394:
grants already received); M.P. Kast
Page 1395 and 1396:
from young rats in order to clarify
Page 1397 and 1398:
Abstract: Enhanced vigilance and at
Page 1399 and 1400:
Page 1401 and 1402:
Page 1403 and 1404:
Page 1405 and 1406:
on lever presses. However, 10mg/kg
Page 1407 and 1408:
NIDA Training Grant DA07237, JWK Ti
Page 1409 and 1410:
of pharmacological treatments has p
Page 1411 and 1412:
Title: Contextual fear memory is im
Page 1413 and 1414:
Topic: F.02.j. Learning and memory:
Page 1415 and 1416:
affecting cognitive, motor, or expl
Page 1417 and 1418:
treatment consisted on 11 injection
Page 1419 and 1420:
Abstract: Background: Dopamine (DA)
Page 1421 and 1422:
Title: Triple knockouts of the mous
Page 1423 and 1424:
Support: Virginia Tobacco Settlemen
Page 1425 and 1426:
1 Dept. of Neurol., Nagoya City Uni
Page 1427 and 1428:
suggest that decreased activity in
Page 1429 and 1430:
292. Acetylcholine, Neurotrophins,
Page 1431 and 1432:
hemifield and tested in the opposit
Page 1433 and 1434:
the β4 nAChR subunit. Mice were te
Page 1435 and 1436:
Title: Cortical brain derived neuro
Page 1437 and 1438:
Page 1439 and 1440:
Center for Behavioral Neuroscience
Page 1441 and 1442:
Poster 293. Startle and Modulation
Page 1443 and 1444:
percentage of open arm entries. For
Page 1445 and 1446:
Topic: F.02.f. Fear and aversive le
Page 1447 and 1448:
Disclosures: J. Lass-Hennemann, Non
Page 1449 and 1450:
Program#/Poster#: 293.10/SS38 Topic
Page 1451 and 1452:
Disclosures: X. Zhang , None; Y. Zh
Page 1453 and 1454:
Also, there is a gradient of c-Fos
Page 1455 and 1456:
learning task, after which the baso
Page 1457 and 1458:
Authors: K. OVEREEM 1,2 , *G. E. SC
Page 1459 and 1460:
294. Gene Expression and Fear Learn
Page 1461 and 1462:
does not reach the level of overt f
Page 1463 and 1464:
Neuropsychopharmacol. in press). In
Page 1465 and 1466:
Authors: *P. GARCÍA-DELATORRE, C.
Page 1467 and 1468:
Page 1469 and 1470:
Poster 295. Memory Consolidation, R
Page 1471 and 1472:
Authors: S. A. BAELLA 1 , S. D. IÑ
Page 1473 and 1474:
Page 1475 and 1476:
Topic: F.02.h. Memory modulation, c
Page 1477 and 1478:
Page 1479 and 1480:
Page 1481 and 1482:
Page 1483 and 1484:
Page 1485 and 1486:
to in vivo microdialysis to measure
Page 1487 and 1488:
Authors: E. CASTRO, J. Y. LAGUNA-TO
Page 1489 and 1490:
time-limited role in the transfer t
Page 1491 and 1492:
allow large ensembles of hippocampa
Page 1493 and 1494:
Title: Further characterization of
Page 1495 and 1496:
296. Learning and Memory: Physiolog
Page 1497 and 1498:
Disclosures: S. Yamamoto, None; H.
Page 1499 and 1500:
een difficult to examine whether th
Page 1501 and 1502:
Topic: F.02.i. Learning and memory:
Page 1503 and 1504:
memory circuitry by ketamine that i
Page 1505 and 1506:
Authors: *A. ARDESTANI 1 , F. DARVA
Page 1507 and 1508:
Page 1509 and 1510:
Poster 297. Social Recognition and
Page 1511 and 1512:
administration of the mu-opioid sel
Page 1513 and 1514:
memory (SRM). If the ITI is 60 min,
Page 1515 and 1516:
Page 1517 and 1518:
social interactions. Supported by N
Page 1519 and 1520:
of mate choice copying and the “t
Page 1521 and 1522:
297. Social Recognition and Partner
Page 1523 and 1524:
we examined the neuronal activity i
Page 1525 and 1526:
Recent evidence indicates that the
Page 1527 and 1528:
Abstract: Previous studies have fou
Page 1529 and 1530:
Authors: *D. K. TAYLOR, K. KOTWICA,
Page 1531 and 1532:
stimulation lever back to the maxim
Page 1533 and 1534:
feeding produced by predator stress
Page 1535 and 1536:
(DAT) knockdown mice, with only 10%
Page 1537 and 1538:
intraorally administered sucrose so
Page 1539 and 1540:
eactions to tastes, possibly implic
Page 1541 and 1542:
the amygdala. Surprisingly, sucrose
Page 1543 and 1544:
21680 administration decreased base
Page 1545 and 1546:
We have studied the effect of OSU-6
Page 1547 and 1548:
NIMH Title: The N-terminal domain o
Page 1549:
animals was observed. A history of
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