[Abstract Title]. - Society for Neuroscience

are associated with ketamine-induced oxidative DNA damage as indicated by increased 8oxoguanine
expression and decreased expression of the DNA repair enzyme hOGG1.
Disclosures: C. Wang, FDA/NCTR E-7189, NTP/NIEHS and NICHD, B. Research Grant
(principal investigator, collaborator or consultant and pending grants as well as grants already
received); N. Sadovova, None; T.A. Patterson, None; X. Zou, None; X. Zhang, None; M.M.
Paule, None; J.P. Hanig, None; W. Slikker, None.
Poster
232. Developmental Cell Death: Biological Effects
Time: Sunday, November 16, 2008, 1:00 pm - 5:00 pm
Program#/Poster#: 232.10/B50
Topic: A.06.a. Developmental cell death: Biological effects
Support: Merit Award HD37100
NIH Grant NS057105
Title: Neonatal phencyclidine exposure induces strain-dependent effects on agonistic behaviors
in ICR mice
Authors: *C. M. YUEDE, S. E. MALONEY, C. E. CREELEY, N. B. FARBER, J. W. OLNEY,
D. F. WOZNIAK;
Dept Psychiatry, Washington Univ., St. Louis, MO
Abstract: It is well established that NMDA receptor antagonists induce widespread apoptotic
neurodegeneration in the developing rodent brain, and that various neuronal populations exhibit
differential sensitivities to this damage depending on the age of exposure during the early
neonatal period of synaptogenesis. Thus, exposing rodents to these agents at different times
during early development may induce a wide range of functional disturbances later in life. We
previously reported at these meetings (Yuede et al., 2006) that exposing male C57Bl/6J (B6)
mice to phencyclidine (PCP) on postnatal days 2 and 7 (P2+P7) produced chronic, heightened
aggression as measured by the resident intruder test, which was likely due to a permanent
alteration of brain circuitry resulting from PCP-induced neuroapoptosis. Here we report that
exposing male ICR mice to the same PCP treatment also produced changes in certain agonistic
behaviors but not on the indices of aggression that were significantly increased in B6 mice. The
present study included additional male control (deprived) mice that were injected with saline but
kept from the dam for the same amount of time that the PCP-treated mice were away from their
mothers (8 h). On P30 the mice were evaluated on a reactivity to handling test and PCP-treated