[Abstract Title]. - Society for Neuroscience

Topic: B.11.b. Cell biology and signalling
Support: CIHR
OMHF
Title: Citalopram mediated neural progenitor cell proliferation and survival
Authors: *A. S. PETTIT, S. A. L. BENNETT;
Dept Biochem, Micro, Immuno, Univ. of Ottawa, Ottawa, ON, Canada
Abstract: Depression is associated with a decreased hippocampal volume that correlates with
the length of the depressive episode. Converging evidence suggests that this pathology results
from both progressive loss of neurons and glia and impaired regeneration. Successful
amelioration of the depressive phenotype by chronic antidepressant treatment correlates with an
increase in neural progenitor cell (NPC) proliferation and maturation in experimental models of
disease matching the kinetics of clinical antidepressant efficacy. These correlations have led
researchers to hypothesize that neurogenesis is required for antidepressant drug action.
Citalopram, a selective serotonin reuptake inhibitor, is one of the most widely prescribed
antidepressants on the market to date. Few studies have examined the impact of citalopram on
cell proliferation and maturation in the subgranular zone (SGZ) of the dentate gyrus of the
hippocampus, one of the primary sites of neurogenesis in the adult mammalian brain. Using
halogenated thymidine analogue labeling, we have studied the effect of subchronic (7 or 14 day)
and chronic (28 day) citalopram treatment on NPC proliferation and survival in the SGZ of
wildtype mice identifying the progenitor subtypes responsive to antidepressant treatment.
Disclosures: A.S. Pettit , None; S.A.L. Bennett, None.
Poster
241. Glial Neuronal Interactions
Time: Sunday, November 16, 2008, 1:00 pm - 5:00 pm
Program#/Poster#: 241.11/G5
Topic: B.11.b. Cell biology and signalling
Support: NINDS, NIH Intramural Funds
Title: Site specific phosphorylation of human septin 5 (sept5) at serine 327 by cyclin dependent
kinase 5 regulates secretion