[Abstract Title]. - Society for Neuroscience

observed as a result consistent with that of test 4.
Discussion
The results of test 1, test 2 and test 3 are also considered to be similar to the patterns of cortical
atrophy in AD that were observed in previous studies. In this study, cortical atrophy was
apparently present in cerebellum. It is not yet clarified whether the cerebellar change is related to
the clinical progression or prognosis of AD. If there is a relation between them, however, it is
thought that the studies of cerebellum could contribute to the treatment and management of AD.
Therefore, a variety of studies for cerebellums, as well as cerebrums in AD is required from now
on.
Disclosures: Y. Youn , None; P. Kim, None; S. Chae, None; S. Kim, None.
Poster
246. Alzheimer's Imaging and Biomarkers II
Time: Sunday, November 16, 2008, 1:00 pm - 5:00 pm
Program#/Poster#: 246.6/P10
Topic: C.01.o. Imaging and biomarkers
Title: Subcellular localization of the neuronal retromer: Insight into its role in hippocampal
function and Alzheimer‟s disease
Authors: *A. BHALLA 1 , G. DI PAOLO 2 , S. A. SMALL 3 ;
1 Taub Inst., 2 Taub Inst. and Dept. of Pathology, 3 Taub Inst. and Dept. of Neurol., Columbia
Univ., New York, NY
Abstract: First described in yeast, the retromer sorting pathway consists of a multimeric
retromer complex and a retromer-binding receptor, VPS10. Mammalian homologues of the
retromer complex have been identified, and mammals express a family of VPS10-containing
molecules, all highly expressed in the brain. To date two members of this family, sorLA and
sortilin, have been shown to act as retromer-binding receptors in the brain.
A range of gene-expression and genetic studies in humans, and biochemical and behavioral
studies in animal models, have implicated the retromer sorting pathway in late-onset Alzheimer‟s
disease. Furthermore, the retromer complex is differentially expressed in the hippocampal
formation. Nevertheless, the precise role the retromer sorting pathway plays within neurons
remains unknown.
Here, we provide initial insight into this question by performing a series of co-labeling
immunocytochemistry studies to determine the subcellular localization of the retromer complex
in cultured hippocampal neurons. Although axonal staining could not be excluded, neuronal
VPS35, the core element of the retromer complex, was found to have a predominant