[Abstract Title]. - Society for Neuroscience

against the botulinum neurotoxin type A heavy or light chain or against the full complex.
Separation fractions were functionally analyzed using the mouse hemidiaphragma assay.
The 150 kDa neurotoxin type A molecule is released from the 900 kDa complex in less than one
minute when exposed to physiological pH values (pH 7.2-7.6).
It is concluded that the 150 kDa botulinum neurotoxin type A molecule is released from the 900
kDa complex in less than one minute when exposed to physiological pH values. This time frame
is extremely short in comparison to the onset of the therapeutic effect which is measured in days.
Therefore, the complexing proteins cannot stabilize the neurotoxin or inhibit its diffusion as
claimed. Accordingly, the necessity of these complexing proteins in medicinal formulations must
be questioned. Finally, these data aid in understanding the clinical equipotency of Xeomin(1), the
150 kDa botulinum neurotoxin type A molecule free of complexing proteins, and botulinum
neurotoxin type A preparations containing complexing proteins.
(1) not approved for marketing in the USA
Disclosures: K.H. Eisele, Merz Pharmaceuticals, A. Employment (full or part-time); K.B. Fink
, Merz Pharmaceuticals, A. Employment (full or part-time); H.V. Taylor, Merz Pharmaceuticals,
A. Employment (full or part-time).
Poster
248. Dystonia
Time: Sunday, November 16, 2008, 1:00 pm - 5:00 pm
Program#/Poster#: 248.15/U14
Topic: C.03.j. Dystonia
Title: The effects of a comprehensive sensorimotor retraining program on individuals with
Focal Hand Dystonia vs. normal control participants
Authors: *A. L. MCKENZIE 1 , N. BYL 2 ;
1 Physical Therapy, Chapman Univ., Orange, CA; 2 Physical Therapy and Rehabil. Sci., Univ. of
California at San Francisco, San Francisco, CA
Abstract: Background and Purpose: Focal hand dystonia (FHD), also known as occupational
hand cramps, writer‟s cramp, or musician‟s cramp, is a condition characterized by involuntary,
sustained, co-contraction of the flexors and extensors of the affected digits, resulting in
decreased motor control of the hand during specific tasks. Previously, we reported the effects of
a comprehensive sensorimotor retraining on patients with FHD using both clinical outcomes and
magnetoencephalography, but the effects of such training on normal, healthy controls were not
known. The purpose of this study was to compare clinical parameters for musicians and writers
with FHD to those for normal, healthy control subjects to delineate differences in responses to