[Abstract Title]. - Society for Neuroscience

within the intestinal wall, terminals of these vagal afferents can be distinguished from those of
enteric and spinal neurons.
Disclosures: L.L. Tan, None; C.R. Anderson , None; J.C. Bornstein, None.
Poster
269. Pain: Visceral Pain II
Time: Sunday, November 16, 2008, 1:00 pm - 5:00 pm
Program#/Poster#: 269.7/GG22
Topic: D.08.n. Visceral pain
Title: The visceral antinociception of sigma1 receptor antagonist and its synergy with other
analgesics in mice
Authors: T.-W. KIM 1 , H.-W. KIM 2 , K.-W. KIM 1 , *Y. KWON 1 ;
1 Phamacol, Med. Sch. Chonbuk Natl. Univ., Chonju, Republic of Korea; 2 Dept. of Physiol., Col.
of Med. and Res. Inst. for Med. Sciences, Chungnam Natl. Univ., Daejeon, Republic of Korea
Abstract: It has been demonostrated that sigma 1 receptor antagonist, BD1047, produces
analgesic effect in formalin induced pain behavior. The aim of present study was to determine
the antinociceptive effect of spinal sigma 1 receptor in the model of visceral acute tonic pain, the
acetic-acid writhing test in mice. Furthermore, present study was undertaken to characterize the
interactions between BD1047 and several type of analgesic candidates. Intrathecal pretreatment
of BD 1047 (10, 30, 100 nmol) produced dose-dependent antinociceptive effect against acetic
acid-induced writhing. Intraperitoneal injection of paroxetine, fluoxetine, nixosetine, morphine,
ketamine and acetaminophen dose-dependently produced anti-nociceptive effect in acetic acid
induced pain model. Combination of low analgesic doses of these drugs with low analgesic doses
of BD 1047 (30 nmol) resulted in synergistic interactions. Therefore, the spinal blockage of
sigma 1 receptor has potent analgesic effect in visceral pain. Furthermore, the combination of
potential analgesics with BD 1047 is synergistic, and should allow either to increase their
analgesic efficacy and/or to reduce their side effects.
Disclosures: T. Kim, None; H. Kim, None; K. Kim, None; Y. Kwon , None.
Poster