[Abstract Title]. - Society for Neuroscience

all fields. All search results were imported into EndNote, and duplicate records were omitted. A
total of 250 manuscripts met the implemented search criteria. Data analysis suggested that some
elements, such as adhering to the proper care and use guidelines set by the Institutional Animal
Care and Use Committee, were commonly stated in the methods section of most studies. Other
important aspects however, such as experimenter-blinding, rat diet, and the number of rats
housed per cage, were not consistently reported. A variety of factors affect laboratory animals,
and more precise reporting of the materials and methods utilized in preclinical investigations will
improve the reproducibility of data among laboratories.
Disclosures: J.M. Tall , None; J. Backo, None.
Poster
267. Pain: Pain Models II
Time: Sunday, November 16, 2008, 1:00 pm - 5:00 pm
Program#/Poster#: 267.25/FF31
Topic: D.08.j. Pain models
Support: Department of Veterans Affairs
Title: Temporal analysis of nocifensive reflex or operant behaviors during prolonged thermal
stimulation in the rat
Authors: *R. H. KLINE IV 1 , J. MCDANIEL 2 , L. L. LEMONS 3 , K. CHATTERJEE 6 , S.
DATTA 4 , M. T. HARVEY 7 , C. H. KENNEDY 5 , R. G. WILEY 8 ;
1 Neurol, 2 Special Educ., 3 Ctr. for Cognitive and Intergrative Neurosci., 4 Anesthesiol., 5 Special
Education, Pediatrics, Vanderbilt Univ., Nashville, TN; 6 Neurol., VA TVHS, Nashville, TN;
7 Psychology, Florida Inst. of Technol., Melbourne, FL; 8 Neurology, Pharmacol., VA TVHS,
Vanderbilt Univ., Nashville, TN
Abstract: Contact thermal stimulation has been widely used in psychophysical and
neurophysiological studies of nociception, most often measuring the length of time taken to
produce innate reflex withdrawal responses that can be seen in decerebrate rats. Typically,
thermal withdrawal testing protocols measure the first response latency and use temperatures of
50° C, or more. These stimulus temperatures preferentially activate A-delta thermal nociceptors.
These phasic, high intensity spinal and bulbospinal reflex tests differ in significant ways from the
persistent pain that is so important clinically. Three approaches to address these issues are: 1 -
use of lower intensity stimuli that preferentially activate C nociceptors, 2 - use of sustained
exposure to the stimuli, and 3 - use of responses that require cerebral processing. In the present
study, we sought to characterize the temporal characteristics of pain-related behaviors during