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[Abstract Title]. - Society for Neuroscience

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Authors: *M. CORTÉS 1 , M. L. ITA 1 , D. M. MENDIOLA 1 , A. UGARTE 1 , J. R. EGUIBAR 2 ;<br />

1 Inst. Physiol., 2 Inst. Physiol. and Secrtearia Gen., B. Univ. Autonoma De Puebla, Puebla,<br />

Mexico<br />

<strong>Abstract</strong>: Taiep rats are a myelin mutant with a progressive motor syndrome characterized by:<br />

tremor, ataxia, immobility, epilepsy and paralysis. The main cause of the alteration is a<br />

hypomyelination followed by a progressive demyelination. At 7 months of age the rat´s showed<br />

immobility episodes (IEs) induced by gripping the animals from the tail, during IEs a REM-like<br />

EEG characteristics were obteined. The IEs increase with α1 agonists and with prazosin, an α1<br />

antagonist, and diminished with α2 antagonists. In the present experiment we analyze the effects<br />

of systemic injection of two D3 agonists.<br />

The rats were maintained under standard conditions with free access to water and balanced<br />

rodent pellets (Zeigler, USA). At 8 mo of age male taiep rats with an increased dose scheme 7-<br />

OH-DPAT (1 to 1,000 µg/kg) and PD-128907 (1 to 1,000 µg/kg) at 900 AM<br />

Our results showed that 7-OH-DPAT produce an increase in the frequency to 13.3 ± 0.9 of IES<br />

respect to control with 6.8 ± 1.1 with highest dose (P

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