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[Abstract Title]. - Society for Neuroscience

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Program#/Poster#: 295.11/SS61<br />

Topic: F.02.h. Memory modulation, consolidation, and reconsolidation<br />

Support: CONACyT 60478<br />

DGAPA-UNAM IN220706<br />

<strong>Title</strong>: Dorsal hippocampus is differentially involved in consolidation of extinction but not<br />

consolidation of aversive taste memory<br />

Authors: *I. BALDERAS, C. RODRIGUEZ-ORTIZ, A. ISLAS, J. CHAVEZ-HURTADO, F.<br />

BERMUDEZ-RATTONI;<br />

Neurociencias, IFC-UNAM, Mexico city, Mexico<br />

<strong>Abstract</strong>: Taste recognition memory is an important ability that animals have developed<br />

throughout evolution in order to respond efficiently to the consumption of edibles. In laboratory<br />

conditions when a novel taste is presented and has adverse consequences (e.g. induced gastric<br />

malaise), the animal develops a long-lasting taste aversion (CTA). Afterward, an increased<br />

consumption is observed in subsequent presentations when the taste is not followed by gastric<br />

malaise, this behavior is called extinction. The participation of the hippocampus in taste<br />

recognition memory <strong>for</strong>mation has been slightly studied and results are controversial. Some<br />

studies showed lack of effects in CTA after lesions of the hippocampus; while others reported an<br />

enhancement in CTA. We studied if protein synthesis in the dorsal hippocampus is required <strong>for</strong><br />

long-term aversive taste memory and its extinction. The protein synthesis inhibitor anisomycin<br />

was locally injected immediately after acquisition and either long-term CTA or extinction taste<br />

memory was tested. The results showed that anisomycin applied into the hippocampus disrupted<br />

consolidation of extinction memory. Interestingly, anisomycin infusions into the hippocampus<br />

did not affect CTA memory consolidation. These results suggest that the hippocampus has a<br />

differential involvement in the consolidation of taste recognition memories, depending on the<br />

taste association to appetitive or aversive signals.<br />

Disclosures: I. Balderas , None; C. Rodriguez-Ortiz, None; A. Islas, None; J. Chavez-<br />

Hurtado, None; F. Bermudez-Rattoni, None.<br />

Poster<br />

295. Memory Consolidation, Reconsolidation, Anatomy, and Mechanisms<br />

Time: Sunday, November 16, 2008, 1:00 pm - 5:00 pm<br />

Program#/Poster#: 295.12/SS62

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