[Abstract Title]. - Society for Neuroscience

of the
rats to mechanical and thermal stimuli were reduced,and there were physical difficulties in
ingestion.
Furthermore,the periods of facial grooming were prolonged post-inoculation,as compared with
those in the sham group.In the trigeminal subnuclei caudalis,the level of c-Fos immunoreactivity
of the ips-
ilateral side was increased significantly on days 4,7 and 10 post-inoculation,as compared with
those of
the contlateral side and in the sham group.However,substance and calcitonin gene-related
peptide levels in the trigeminal subnuclei caudalis were not changed in the facial cancer model
whereas they
were increased in facial inflammation model of rat.These results suggest that neuropathic pains
in the
facial cancer model are probably caused by different pathway of inflammation-induced.
Disclosures: N. Harano, None; O. Nakanishi, None; K. Ono, None; K. Inenaga, None.
Poster
267. Pain: Pain Models II
Time: Sunday, November 16, 2008, 1:00 pm - 5:00 pm
Program#/Poster#: 267.23/FF29
Topic: D.08.j. Pain models
Support: GACR 305/07/0242
RG 0021620816
GACR 305/06/1188
Title: Age-related changes of nociceptive threshold in rats
Authors: *S. VACULIN, M. FRANEK;
Dpt of Physiol., UK,3th Fac. of Med., Praha, Czech Republic
Abstract: The effect of age on pain thresholds has not been fully explained in both human and
animal research. Several studies described pain threshold increase in older adults compared to
young adults in men, however, reduction of noxious inhibitory system was revealed during
aging. The aim of the present study was to determine nociceptive threshold in rats during their
lifetime. Nociceptive thresholds were evaluated using paw withdrawal latency to thermal and