[Abstract Title]. - Society for Neuroscience

Frey filament with strength of 0.68 mN. The behavior was observed by video recording and the
duration of licking behavior was measured. The action potentials of the saphenous nerve were
extracellularly recorded with a bipolar hook electrode. Oxaliplatin produced mechanical
allodynia from day 3 after injection, reached the peak at day 10 and completely subsided by day
21. Increased spontaneous licking behavior was observed at day 10 after the injection.
Electrophysiological study showed that the spontaneous nerve activity was significantly higher
in oxaliplatin-treated mice than in the control ones. Furthermore, mechanical sensitivity was
significantly higher in oxaliplatin-treated mice in comparison to vehicle-treated ones. These
results suggest that oxaliplatin causes neuropathic pain at least through the development of
spontaneous discharge and increase in mechano-sensitivity of the afferent nerve.
Disclosures: P. Gauchan, None; Y. Kuraishi , None; T. Andoh, None; A. Sasaki, None; A.
Kato, None.
Poster
269. Pain: Visceral Pain II
Time: Sunday, November 16, 2008, 1:00 pm - 5:00 pm
Program#/Poster#: 269.1/GG16
Topic: D.08.n. Visceral pain
Support: Science Foundation Ireland
Glaxo Smith Kline
Industrial Development Agency, Ireland
Title: Altered cortical cellular activation in an animal model of early-life stress: Effects of
psychological and colorectal distension -induced stressors in adulthood
Authors: *S. M. GIBNEY 1 , R. D. GOSSELIN 1 , T. G. DINAN 2 , J. F. CRYAN 3 ;
1 NeuroGastroenterology, Alimentary Pharmabiotic Ctr., Cork, Ireland; 2 Psychiatry, 3 Pharmacol.
and Therapeut., Univ. Col. Cork, Cork, Ireland
Abstract: A clear aetiology and understanding of the mechanisms underlying irritable bowel
syndrome (IBS) have not been fully elucidated. However, there is evidence that early life trauma
and ongoing psychological stress in humans can affect the clinical course of this disorder.
Alterations in stress responsivity and visceral pain are among the many hallmarks of irritable
bowel syndrome (IBS). The pattern of altered physiological responses to psychological and
visceral stressors reported in IBS patients is comparable to those seen in the maternally separated