[Abstract Title]. - Society for Neuroscience

the WM network. Furthermore, individuals homozygous for the risk allele exaggerated the
previously found relationship between high capacity and increased activation in the right
DLPFC. Variation in activation of the WM network associated with information processing can
be accounted for in part by WM capacity and NOS1AP genotype. These data indicate that neural
function associated with WM deficits in schizophrenia may be modulated by NOS1AP and that
efficiency regions and capacity regions of the WM network are affected.
Disclosures: L.A. Libby , None; K.K. Nicodemus, None; R.G. Higier, None; M.J. Prust,
None; H. Tan, None; J.W. Buckholtz, None; B. Kolachana, None; R.E. Straub, None; D.R.
Weinberger, None; J.H. Callicott, None.
Poster
288. Working Memory: Disorders, Genes and Connectivity
Time: Sunday, November 16, 2008, 1:00 pm - 5:00 pm
Program#/Poster#: 288.24/RR31
Topic: F.01.f. Working memory
Support: University of Cincinnati, Center for Imaging Research
NIH Grant NIDA K01 DA020485
NIH Grant NIDA R01 DA022221-02S2
University of Cincinnati, Dean's Discovery Fund
Title: fMRI brain activation in recreational ecstasy (MDMA) users during working memory
Authors: *J. B. ALLENDORFER 1,2 , M. LAMY 1,2 , J. C. ELIASSEN 3,2 ;
1 Neurosci Grad Prog, 2 Ctr. for Imaging Res., 3 Dept. of Psychiatry, Univ. Cincinnati, Cincinnati,
OH
Abstract: Ecstasy is a widely abused street drug, with a lifetime prevalence of about 10-14% for
college students. MDMA, or 3,4-methelenedioxy-methamphetamine, is the primary psychoactive
substance in ecstasy, and has been shown in animal studies to damage serotonergic neurons and
to impair memory performance. However, due to the variability of drug exposure in humans, the
cognitive and functional consequences of recreational ecstasy (MDMA) use remain unclear. To
investigate the effects of ecstasy use on memory, we studied three groups of subjects: current
ecstasy users (n=12), non-ecstasy drug users (n=10) matched to the ecstasy users by cannabis
use, and non-drug users (n=10). During fMRI, participants performed an N-back task (0-back, 1-