[Abstract Title]. - Society for Neuroscience

everted following striatal embedding of the SiO2-DA reservoir. Notably, the effect was
maintained up to 113 days after implantation without the development of dyskinesias. Rats that
did not receive an implant or that were implanted with an empty dioxide silicon reservoir did not
show any recovery during the study, suggesting that the therapeutic effect on the postural
adjustment observed in the hemiparkinsonian rats was due to the continuous dopamine release
from the SiO2-DA reservoir.
Disclosures: F. Alvarez-Cervera, None; A.S. Castilla-Tirado, None; J.L. Bata-Garcia,
None; J.L. Gongora-Alfaro, None; G. Arankowsky-Sandoval, None; F.J. Heredia-Lopez,
None; T. Lopez-Goerne, None; P. Quintana-Owen, None; D.M. Esquivel-Gomez, None.
Poster
247. Parkinson's Disease Interventions: Animal and Clinical Models
Time: Sunday, November 16, 2008, 1:00 pm - 5:00 pm
Program#/Poster#: 247.10/S5
Topic: C.02.d. Therapies
Support: The Korea Science and Engineering Foundation (KOSEF) grant funded by the Korea
government(MEST) (R11-2005-014)
The Second Stage of Brain Korea 21 project in 2008
Title: The 2-DE analysis of the neuroprotective effect of electroacupuncture in the MPTPinjected
mouse striatum
Authors: *S.-T. KIM 1,2 , H.-J. YOO 2 , S.-N. KIM 1 , C. YIN 2 , W. MOON 2 , H.-J. LEE 2 , H.-J.
PARK 1 ;
1 Col. of Oriental Med., Kyung Hee Univ., Seoul, Republic of Korea; 2 Acupuncture & Meridian
Sci. Res. Center, KyungHee Univ., Seoul, Republic of Korea
Abstract: Parkinson's disease (PD) is characterized by the loss of dopaminergic neurons in
substantia nigra (SN), and dopaminergic neuronal fibers in striatum (ST) were also destructed.
But the pathogenic mechanism remains still unknown.
Using a mouse model of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced PD, we
investigated whether electroacupuncture normalizes the proteomic changes by MPTP in the mice
ST.
C57BL/6 mice were injected i.p. with 30 mg/kg of MPTP at 24 h interval for 5 days, and 100 Hz
EA treatment was performed at GB34 and GB39 once a day for 12 days consecutively from the
first injection. Then we performed tyrosine hydroxylase (TH)-immunohistochemistry in the ST