[Abstract Title]. - Society for Neuroscience

we further tested the idea that stimulation of food intake reduces emesis by using food
deprivation to stimulate appetite. Twenty-four h, but not 3 h, of fasting was sufficient to
stimulate feeding in house musk shrews (Suncus murinus) and completely blocked emetic
episodes produced by the chemotherapy agent cisplatin (20 mg/kg; a peripheral stimulus), and
reduced the emetic effects of nicotine (2 mg/kg; a central stimulus). Emetic episodes need not
produce an actual expulsion of gastric contents because animals will still retch in response to
toxins. Contents of the stomach did not account for the reduction of emesis by 24 h food
deprivation because only 3 h of food restriction emptied the stomach but was not sufficient to
reduce the number of vomiting episodes. These data indicate that nutritional status has a strong
effect on emesis and suggest that nutritional strategies could be employed as an adjunct to antiemetic
drugs to help control emesis.
Disclosures: C.C. Horn , None; C.E. Fitzgerald, None; M.I. Friedman, None.
Poster
284. Regulation of Food Intake and Body Weight: Integration of Peripheral Signals:
Systems
Time: Sunday, November 16, 2008, 1:00 pm - 5:00 pm
Program#/Poster#: 284.19/QQ14
Topic: E.07.b. Integration of peripheral signals: Systems
Support: NIDA 5P01DA021633-02 (HA and SJW)
Pritzker Neuropsychiatric Disorders Research Consortium (SJW)
Office of Naval Research N00014-02-1-0879
Title: Dietary self-selection in aged metabolic syndrome rats
Authors: *P. R. BURGHARDT 1 , S. BRITTON 2 , L. KOCH 2 , S. J. WATSON 1 , H. AKIL 1 ;
1 Molec & Behav Neurosci Inst., Univ. Michigan, Ann Arbor, MI; 2 Physical Med. & Rehabil.,
Univ. of Michigan, Ann Arbor, MI
Abstract: Metabolic syndrome increases risk for developing a number of other diseases.
Biological changes that occur during aging influence energy management however the
interaction between age and energy management is not understood. Selective breeding of rats for
the ability to run to exhaustion on a treadmill has produced lines with divergent running capacity
termed high-capacity runners (HCR) and low capacity runners (LCR). In order to determine the
role of age and reproductive status on dietary selection, 12- and 18-month old female HCR and