[Abstract Title]. - Society for Neuroscience

present study examined the activities of DRN 5-HT neurons and PVN CRF neurons to 30 min of
treadmill running with different speeds (25m/min; 15m/min; control, just sitting on a treadmill)
in male Wistar rats, using c-Fos/5-HT or CRF immunohistochemistry. We also performed an
open field test after the treadmill running to evaluate the effect of physical exercise on anxietylike
behavior. Low intensity exercise, but not high intensity induced a significant increase of c-
Fos positive 5-HT neurons compared to control. The number of c-Fos positive CRF neurons was
increased speed-dependently. Locomotor activities in the open field test were decreased by
physical exercise, especially with low intensity. These results suggest that low intensity exercise
can effectively induce antidepressant/anxiolytic properties of physical exercise.
Disclosures: T. Otsuka, None; I. Kita , None; N. Kubota, None; S. Yanagita, None.
Poster
282. Stress and the Brain: Cellular Actions of Stress
Time: Sunday, November 16, 2008, 1:00 pm - 5:00 pm
Program#/Poster#: 282.8/OO15
Topic: E.06.d. Cellular actions of stress
Support: SHRF
NSERC
Title: Downregulation of reelin in an animal model of depression is reversed by antidepressants
and correlates with alterations in neural integration in the adult dentate gyrus
Authors: *E. Y. FENTON 1 , N. M. FOURNIER 1 , A. L. LUSSIER 1 , H. J. CARUNCHO 2 , L. E.
KALYNCHUK 1 ;
1 Dept. of Psychology, Univ. of Saskatchewan, Saskatoon, SK, Canada; 2 Dept. of Cell Biol.,
Univ. of Santiago de Compostela, Galicia, Spain
Abstract: Current hypotheses about the neurobiology of depression are focused on hippocampal
neurogenesis. The idea is that decreased neurogenesis may play a causal role in depression.
However, recent evidence has challenged this hypothesis. For example, post mortem analyses
have revealed that human patients with depression do not have decreased neurogenesis. It may
therefore be important to focus attention on the maturation and function of surviving cells, rather
than the loss of cells per se. Reelin is a glycoprotein that may play a key role in cell survival and
migration. Interestingly, reelin has been implicated in a number of neuropsychiatric disorders,
including depression. Although reelin is important for neuronal migration during embryonic
development, it also appears to play a prominent role in synaptic plasticity, memory processing,