[Abstract Title]. - Society for Neuroscience

Poster
246. Alzheimer's Imaging and Biomarkers II
Time: Sunday, November 16, 2008, 1:00 pm - 5:00 pm
Program#/Poster#: 246.5/P9
Topic: C.01.o. Imaging and biomarkers
Support: This study was supported by a grant of the Korea Health 21 R&D Project, Ministry of
Health & Welfare, Republic of Korea.( A050079)
Title: The changes of cerebellar cortical gray matter of the alzheimer disease according to
clinical dementia rating: Voxel Based Morphometric Study
Authors: *Y.-C. YOUN 1 , P.-S. KIM 1 , S. CHAE 2 , S. KIM 3 ;
1 Neurol., 2 Pediatrics, Chung-ang Univ. Hosp, Seoul, Republic of Korea; 3 Neurol., Seoul Natl.
Univ. Bundang Hasp., Bundang, Republic of Korea
Abstract: Introduction
The symptoms of Alzheimer's disease (AD) have a correlation with cerebral cortical atrophy.
This study is designed to compare the change of gray matter feature of AD patient according to
CDR with voxel-based morphometry (VBM).
Methods
The 77 patients aged of 60 years and above with impairment of memory and cognition
underwent assessments of CDR, history of the disease, full neuropsychological tests including
memory, language, visuospatial, frontal executive functions, and 3D volumetric brain MRI. We
selected a group of patients who are fulfilling the AD criteria suggested by DSM-IV and
NINCDS-ADRDA. As a result, only 22 patients were selected finally. For control, 22 normal
individuals without any specific health problem or medication history that can affect cognitive
function were recruited, and like the patients, 3D volumetric brain MRI were obtained. The
patients were divided into patient group 1 of CDR 0.5, patient group 2 of CDR 1, and patient
group 3 of CDR 2, and the control subjects were assigned for each patient group as control group
1, 2, and 3 by matching the sample sizes and ages via sampling with replacement. For
quantitative analysis, the 3D volumetric brain MRI images from each individual of patient
groups and control groups were reconstructed with the presented standard VBM protocol:
realignment, spatial normalization, segmentation, and smoothing.
Results
In test 1 that patient group 1 vs, control group 1, the tendency of cortical atrophy to occur mainly
in medial temporal lobe including hippocampal region could be found. In test 2 that patient
group 2 vs, control group 2 and test 3 that patient group 3 vs, control group 3, atrophy emerged
in temporal lobe, gradually involved parietal lobe, and then extended into frontal lobe; finally,
atrophy of overall cortex progressed. In test 4 that patient group 1 vs, patient group 2, it was
revealed that cortical atrophy of cerebellum was more prominent in patient group 2. And in test 5
that patient group 2 vs, patient group 3, the progression of atrophy in cerebellum was also