[Abstract Title]. - Society for Neuroscience

TMEV infection subsequently augments the development of chronic demyelinating disease and
that the impact of stress on disease course may be partially dependent on genetic factors such as
sex. These findings may shed light on clinical findings that stress exacerbates MS disease course
(Mohr et al., 2004) and that men develop more severe clinical symptoms and deteriorate more
rapidly than women (Cottrell et al., 1999).
Disclosures: E.E. Young , None; A.N. Sieve, None; E.G. Vichaya, None; L.M. Carcoba,
None; A. Ambrus, None; R. Storts, None; C.R. Young, None; C.J.R. Welsh, None; M.W.
Meagher, None.
Poster
251. Demyelinating Disorders: Animal Models and Human Studies I
Time: Sunday, November 16, 2008, 1:00 pm - 5:00 pm
Program#/Poster#: 251.26/W19
Topic: C.08.b. Animal models
Support: Department of Veterans Affairs Biomedical Laboratory R&D Grant
NIH Grant NS45445
National Multiple Sclerosis Society Grant RG3405-B-5
NIH Grant NS49210
Title: Estrogen affects IL-17 levels in female mice with experimental autoimmune
encephalomyelitis
Authors: *M. A. YATES 1,2 , S. SINHA 1,2 , L. J. KALER 1,2 , H. OFFNER 1,2,3 ;
1 Neurol., Oregon Hlth. & Sci. Univer, Portland, OR; 2 Neuroimmunology Res., Veterans Affairs
Med. Ctr., Portland, OR; 3 Dept. of Anesthesiol. and Perioperative Med., Oregon Hlth. & Sci.
Univ., Portland, OR
Abstract: Estradiol (E2) treatment has previously been demonstrated to protect against the
development of experimental autoimmune encephalomyelitis (EAE) in female mice. However,
the effects of E2 treatment on production of interleukin-17 (IL-17), which is important in the
pathogenesis of EAE, have not been explored. To further investigate the mechanism behind
estrogen‟s protective effects, female C57Bl/6 mice were implanted with 2.5mg 17β-estradiol
pellets (60 day release) before immunization to induce EAE. Compared to controls, females
implanted with E2 were protected against the development of EAE. Brains, spleens, and lymph