[Abstract Title]. - Society for Neuroscience

Poster
240. Intrinsic Membrane Properties: Modulation of Neuronal Firing Properties by Inputs
and Activity
Time: Sunday, November 16, 2008, 1:00 pm - 5:00 pm
Program#/Poster#: 240.7/E29
Topic: B.10.b. Modulation of neuronal firing properties
Title: The electrophysiological characterization of Substance P sensitive muscle afferent
neurons
Authors: *C.-C. J. LIN;
Academia Sinica, Taipei, Taiwan
Abstract: Peripheral substance P (SP) is well known for its role in inflammatory pain and its
involvement in the phenomenon of neurogenic inflammation and central sensitization.
Nontheless, its role in acid induced muscle pain still remained as a less-studied aspect of its
biology. This study utilized whole-cell patch recording to characterize the properties of the
muscle afferent DRG neurons. Lumbar dorsal root ganglion (DRG) neurons retrogradely labeled
with 4 % fluoro-gold from gastrocnemius muscle were used. The current clamp experiment
showed that the treatment of SP could attenuate or reverse the depolarizing membrane potential
induced by the initial treatment of acid in ~76% of muscle afferent neurons. On the other hand,
the voltage clamp study demonstrated that SP had different effects on acid-evoked current.
Muscle innervated DRG neurons were more responsive to acidic treatment than non-muscle
ones. Moreover, a subpopulation of neurons was found only within muscle afferent DRG
neurons to exhibit outward current upon SP treatment. The data so far indicated that SP has the
ability to modulate acid-sensing properties of muscle afferent neurons.
Disclosures: C.J. Lin , None.
Poster
240. Intrinsic Membrane Properties: Modulation of Neuronal Firing Properties by Inputs
and Activity
Time: Sunday, November 16, 2008, 1:00 pm - 5:00 pm
Program#/Poster#: 240.8/E30
Topic: B.10.b. Modulation of neuronal firing properties