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Geven en nemen - dr Erwin JO Kompanje

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abs<strong>en</strong>t as a result of a terminal circulatory arrest of a duration of more than 10<br />

minutes.<br />

In c1/apter <strong>JO</strong> the pot<strong>en</strong>tialof postmortem argan donars is investigated, and<br />

the causes of clinical brain death assessed. In 85% of the cases the cause was<br />

severe head injury, due to trauma (c. 35%) or a cerebrovascular accid<strong>en</strong>t, most<br />

frequ<strong>en</strong>tlya subarachnoid hemorrhage (c. 50%). The incid<strong>en</strong>ce of clinical brain<br />

death in these hvo groups has decreased because of improved sociodemographic<br />

circumstances and therap<strong>en</strong>tic modalities. In traumatic brain injury clinical brain<br />

death occurs usuaUy within the first 48 hours after trauma. In pati<strong>en</strong>ts with a<br />

subarachnoid hemorrhage clinical brain death resnlts much later, usually in<br />

the first three weeks after the initial bleed, due to recurr<strong>en</strong>t bleeding or delayed<br />

cerebral ischemia. Each year betwe<strong>en</strong> 135 and 220 pati<strong>en</strong>ts younger than 70 years<br />

die within the first h\'o weeks after admission for a subarachnoid hemorrhage.<br />

Approximately 400 pati<strong>en</strong>ts die each year in the first two days after admission for<br />

traumatic head injury. It has however not be<strong>en</strong> determined how many of these<br />

pati<strong>en</strong>ts die due to clinical brain death.<br />

Care of pati<strong>en</strong>ts with severe traumatic head injury or snbarachnoid hemorrhage<br />

should be conc<strong>en</strong>trated in hospitals with neurosurgical facilities. The<br />

pot<strong>en</strong>tial for non-heart beating kidnel' donors mal' be considerable, although an<br />

accurate estimation is difficult. This type of donation strongly dep<strong>en</strong>ds on cooperation<br />

of the hospital personnel. lnformation for smaller hospitals concerning<br />

organ donation should focus more on possibilities for non-heart beating kidney<br />

donation.<br />

In c1/apter 11 the soeiaUy relevant aspects of postmortem organ donation are<br />

discussed. The information imparted by the governm<strong>en</strong>t, concerning the institution<br />

of the c<strong>en</strong>tral donor registration is criticaIJl' analyzed. It is concluded<br />

that the information provided is insuffici<strong>en</strong>t to p<strong>en</strong>nit careful decision making.<br />

The consequ<strong>en</strong>ces of organ donation for the human body and integrity are<br />

nuther discussed. Exclusion of persons bel on ging to so-called risk groups, snch as<br />

f.L for HIV infection, from organ donation has caused much discussion in 1998.<br />

Exclusion of pati<strong>en</strong>ts trom such subgroups, as weU as because of other diseases, is<br />

discussed. It is concluded that the risk of stigmatization and discriminatioIl, resulting<br />

from exclusion of snch risk groups, is nearly unavoidable. The moral basis for<br />

postmortem organ donation is analyzed. HumanitarÏan solidarity, in the s<strong>en</strong>se of<br />

willingness to take over part of existantional risk of other human beings, forms<br />

the basis for the moral acceptance of postmortem organ donation. Finally, the<br />

cons<strong>en</strong>t for organ donation giv<strong>en</strong> by relatives is ad<strong>dr</strong>essed. The frequ<strong>en</strong>tly<br />

comm<strong>en</strong>ded Spanish model is analyzed and found to be moraU)' incorrect on<br />

manyaspects.<br />

414 SUMMARY

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