TRADITIONAL POSTER - ismrm

Poster Sessions
Antonio, San Antonio, TX, United States; 4 Neurology, UT Health Science Center at San Antonio, San Antonio, TX, United States;
5 Radiology, University of Pennsylvania, Philadelphia, PA, United States
This study reports the implementation and optimization of a pseudo-continuous arterial-spin-labeling technique for non-human primate (baboon) research on
a Siemens 3T TIM-Trio. High-contrast basal cerebral-blood-flow (CBF) images were obtained in 2 mins at 2x2x5 mm resolution. CBF of gray matter and
white matter was analyzed for two commonly used anesthetics: isoflurane and ketamine. Moreover, CBF-based fMRI, obtained with a 7-s resolution,
showed robust hypercapnia-induced CBF changes. This technology is expected to provide a non-invasive means to study physiology, function, and
neurovascular coupling for non-human primate research.
1714. Pulsed Arterial Spin Labeling of Hypo- And Hyperventilated Mice
Tom Dresselaers 1 , Wouter Oosterlinck 2 , Wim Robberecht 3 , Paul Herijgers 2 , Uwe Himmelreich 1
1 Biomedical NMR unit - MoSAIC, K.U.Leuven, Leuven, Belgium; 2 Experimental Cardiac Surgery, K.U.Leuven, Leuven, Belgium;
3 Exp. Neurology, K.U.Leuven, Leuven, Belgium
Arterial spin labeling methods have been widely used to study perfusion of the brain in rats and, to some extent, in mice. To study the cerebral vascular
response animals are challenged with gas mixtures to induce hypercapnia or hypoxia. However, in free-breathing animals partial respiratory compensation
can not be excluded. Additionally, different respiratory levels have been noted depending on strain or transgenic model or age.We demonstrate in this study
how hyper and hypocapnia can be obtained in ventilated mice by adjusting the ventilation rate and tidal volume. CBF was monitored using FAIR-ASL of the
brain during this protocol.
1715. Correction for the T2 Effect of Contrast Agent on Absolute CBV Quantification Using VASO
Fu-Nien Wang 1 , Chien-Chung Chen 1 , Yi-Chun Wu 1 , Chou-Ming Cheng 2 , Tzu-Chen Yeh 2
1 Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Hsinchu, Taiwan, Taiwan; 2 Medical Research
and Education, Taipei Veterans General Hospital, Taipei, Taiwan, Taiwan
Absolute cerebral blood volume (aCBV) can be assessed by utilizing the signal difference of vascular space occupancy (VASO) sequence before and after
injection of T1 shortening contrast agent. We propose an alternative method to reduce the T2 effect when using relative long TE. Pre and post T1 fitting
were used to reconstruct IR images without the post contrast T2 shortening effect. Experiments on rat model were conducted to investigate the feasibilities.
1716. MRI Measures of Cerebral Blood Flow and Cerebrovascular Reactivity in the Developing Swine Brain
Jeff D. Winter 1 , Stephanie Dorner 2 , Joseph A. Fisher 3,4 , Keith St. Lawrence 5,6 , Andrea Kassner 1,7
1 Physiology and Experimental Medicine, The Hospital for Sick Children, Toronto, Ontario, Canada; 2 Respiratory Therapy, University
Health Network, Toronto, Ontario, Canada; 3 Anaesthesiology, University Health Network, Toronto, Ontario, Canada; 4 Physiology,
University of Toronto, Toronto, Ontario, Canada; 5 Imaging Division, Lawson Health Research Institute, London, Ontario, Canada;
6 Medical Biophysics, University of Western Ontario, London, Ontario, Canada; 7 Medical Imaging, University of Toronto, Toronto,
Ontario, Canada
The swine model is an alternative to non-human primates for neuroimaging and may be suitable for studying pediatric cerebrovascular disorders. The aim of
this study was to characterize swine cerebrovascular development using BOLD cerebrovascular reactivity (CVR) and ASL cerebral blood flow (CBF). We
acquired data from 13 juvenile (1-12 wk) pigs. BOLD-CVR measurements exhibited a significant logarithmic increase with body weight (Pearson r>0.81
and p