TRADITIONAL POSTER - ismrm

Poster Sessions
2814. Clinical Prostate T2 Quantification Using a Magnetization-Prepared Spiral Technique
Warren Foltz 1 , Supriya Chopra 1 , Peter Chung 1 , Andrew Bayley 1 , Charles Catton 1 , David Jaffray 1 , Graham
Wright 2 , Masoom Haider 3,4 , Cynthia Ménard 1
1 Radiation Medicine Program, Princess Margaret Hospital, Toronto, Ontario, Canada; 2 Sunnybrook Research Institute, Toronto,
Ontario, Canada; 3 Medical Imaging, University Health Network, Toronto, Ontario, Canada; 4 Medical Imaging, University of Toronto
A magnetization-prepared spiral imaging technique, termed T2prep, was adapted for robust time-efficient clinical prostate evaluation, and piloted in two
prostate cancer cohorts. The patient groups presented with: (A) no prior history of external beam radiation; and (B) biochemical failure after radiotherapy.
Cohorts were scanned (A) without and (B) with an endo-rectal coil in tandem with a torso phased-array, respectively. Prostate zonal and tumor T2 values
supported known trends. For each cohort, an SNR analysis was performed to identify minimum region volumes for thermal-noise insensitive measurements,
and to guide protocol design for future voxel-based anlaysis.
2815. Early Quantititative T1 and T2 Response of the Prostate Gland During Radiotherapy
Warren Foltz 1 , Andy Wu 1 , Anna Kirilova 1 , Peter Chung 1 , Andrew Bayley 1 , Charles Catton 1 , David Jaffray 1 ,
Masoom Haider 2 , Cynthia Ménard 1
1 Radiation Medicine Program, Princess Margaret Hospital, Toronto, Ontario, Canada; 2 Medical Imaging, University Health Network,
Toronto, Ontario, Canada
Magnetization-prepared spiral imaging techniques were adapted for quantitative T2 and T1 characterization of early radiation response in patients with
low/intermediate risk of localized cancer throughout 8-weeks of radiotherapy. Early central gland T2 elevation preceded persistent tumor T2 elevation, and
late reduction in peripheral zone T2; observations which support a known loss of contrast in diagnostic images, and a complementary role for T2 in ADC
and DCE radiation response evaluation. Zonal and tumor T1 measures were insensitive to radiotherapy. However, considerable inter-patient but minor
intra-patient T1 heterogeneities support a sufficiency of baseline T1 scanning for serial quantitative perfusion analysis during radiotherapy.
Cancer (Miscellaneous)
Hall B Thursday 13:30-15:30
2816. MRI-Based ‘Wait-And-See’ Policy in Clinical Complete Responders to Chemoradiation in Rectal
Cancer: A Promising Alternative
Monique Maas 1 , Doenja Lambregts 1 , Ronald van Dam 2 , Patty Nelemans 3 , Guido Lammering 4 , Rob
Jansen 5 , Regina Beets-Tan 1 , Geerard Beets 2
1 Radiology, Maastricht University Medical Center, Maastricht, Limburg, Netherlands; 2 Surgery, Maastricht University Medical
Center, Maastricht, Limburg, Netherlands; 3 Epidemiology, Maastricht University Medical Center, Maastricht, Limburg, Netherlands;
4 Radiotherapy, Maastricht University Medical Center, Maastricht, Limburg, Netherlands; 5 Medical Oncology, Maastricht University
Medical Center, Maastricht, Limburg, Netherlands
When - after neoadjuvant chemoradiation for rectal cancer - imaging could accurately select the complete responders, surgery might safely be omitted and
patients can undergo a wait-and-see policy. This study aims to evaluate whether MRI at 1.5T is accurate enough to select patients for wait-and-see and can
safely be used as a follow-up tool.
2817. N-Stage Assessment in Non-Small Cell Lung Cancer Patients: Comparison of Capability Among STIR
Turbo SE Imaging, Diffusion-Weighted Imaging and FDG-PET/CT
Daisuke Takenaka 1 , Yoshiharu Ohno 1 , Keiko Matsumoto 1 , Hisanobu Koyama 1 , Yumiko Onishi 1 , Munenobu
Nogami 1 , Nobukazu Aoyama 2 , Hideaki Kawamitsu 2 , Kazuro Sugimura 1
1 Radiology, Kobe University Graduate School of Medicine, Kobe, Hyogo, Japan; 2 Division of Radiology, Kobe University Graduate
School of Medicine, Kobe, Hyogo, Japan
FDG-PET/CT can assess morphological and metabolic information at same time, and widely utilized for N-stage assessment in non-small cell lung cancer
(NSCLC) patients. In the last decade, short inversion time inversion recovery (STIR) turbo spin-echo (SE) imaging has been determined at least as valuable
as PET/CT in this setting. Recently, diffusion-weighted image (DWI) is suggested as new technique for differentiation of metastatic lymph nodes from nonmetastatic
lymph nodes. The purpose of this study was to prospectively and directly compare capability of N-stage assessment among integrated FDG-
PET/CT, STIR turbo SE imaging and DWI in NSCLC patients.
2818. Assessment of the Early Response to Chemotherapy with Diffusion-Weighted MRI in Advanced Lung
Cancer Patients-Comparison with FDG-PET-
Tatsuro Tsuchida 1 , Miwa Morikawa 2 , Yukihiro Umeda 2 , Masato Sasaki 3 , Tomohito Kamibayashi 1 ,
Hirohiko Kimura 1
1 Dept. of Radiology, University of Fukui, Fukui, Japan; 2 Dept. of Respiratory Medicine, University of Fukui, Fukui, Japan; 3 Dept. of
Thoracic Surgery, University of Fukui, Fukui, Japan
The purpose of this study was to examine the utility of DWI-MRI for the assessment of early response to chemotherapy in patients with advanced lung
cancer by comparing FDG-PET. Twenty-two lung cancer patients received MRI, FDG-PET, and CT examination before and after 1 cycle of chemotherapy.
Progression-free survival (PSF) between responder and non-responder against chemotherapy was compared by means of % change of ADC and SUV. Both
index indicated that responder demonstrated significant longer PSF and DWI-MRI will be a promising tool for the assessment of the early response to
chemotherapy.