TRADITIONAL POSTER - ismrm

Poster Sessions
6 Radiological Sciences, UCLA School of Medicine, Los Angeles, CA, Los Angeles, CA, United States; 7 Biostatistics, Sanjay Gandhi
Post Graduate Institute of Medical Sciences, Lucknow, UP, India
Thirty-one EHPVO patients along with 23 controls were included in this study. All subjects underwent for neuropsychological tests, measurement of blood
ammonia, MR imaging, 1H-MR spectroscopy. Serum cytokines were measured only in 10 patients and 8 controls. MHE was present in 45% patients.
Significantly increased ammonia, Glx/Cr, and cytokines and MD with decrease in mI/Cr and MTR with no change in Cho/Cr were noted in patients with
MHE compared to controls. Significantly increased Glx/Cr and blood ammonia indicates its central role in the pathogenesis of EHPVO related MHE. The
presence of significant increased serum cytokines in these patients suggest that inflammation also pay an important role in the pathogenesis of MHE.
1995. Understanding Difference in Biochemical, Neuropsychological and Brain MR Imaging Profile of
Minimal Hepatic Encephalopathy Secondary to Cirrhosis and Extrahepatic Portal Vein Obstruction
Santosh Kumar Yadav 1 , Amit Goel 2 , Vivek A. Saraswat 2 , R KS Rathore 3 , M A. Thomas 4 , A Yadav 1 , K N.
Prasad 5 , C M. Pandey 6 , Rakesh Kumar Gupta 1
1 Radiodiagnosis, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India; 2 Gastroenterology,
Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India; 3 Mathematics and Statistics, Indian
Institute of technology Kanpur, Kanpur, Uttar Pradesh, India; 4 Radiological Sciences, UCLA School of Medicine, Los Angeles, CA,
Los Angeles, CA, United States; 5 Microbiology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar Pradesh,
India; 6 Biostatistics, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India
Thirty-three cirrhotic MHE and 14 EHPVO MHE with 23 age/sex matched control were included in final analysis. Liver function test, NPT, CFF, blood
ammonia, proinflammatory molecules, MR imaging and 1H MR spectroscopy were recorded in all patients. MHE was significantly higher in cirrhosis than
EHPVO. Significantly increased blood ammonia, proinflammatory molecules, Glx/Cr and MD with decreased mIns/Cr was observed in both form of MHE
as compared to controls, however Cho/Cr significantly decreased only in cirrhotic MHE as compared to EHPVO MHE and controls. Increased blood
ammonia, proinflammatory molecules, Glx/Cr and MD with decreased mIns/Cr is common in both form of MHE and involved the pathogenesis of MHE,
however Cho/Cr depletion was observed only in cirrhotic MHE, confirms that Cho/Cr depletion is related to liver dysfunction and is unrelated to MHE. Our
study confirms that there are differences in biochemical, proinflammatory molecules and MR profile in MHE of cirrhosis and EHPVO.
1996. Amygdala Network Dysfunction Links Depressive Symptom and Memory Deficit in Elderly with
Amnesic Mild Cognitive Impairment
Chunming Xie 1,2 , Wenjun Li 1 , Joseph Goveas 1 , Piero Antuono 1 , Jennifer Jones 1 , Guangyu Chen 1 ,
Malgorzata Franczak 1 , Zhilin Wu 1 , Shi-Jiang Li 1
1 Medical College of Wisconsin, Milwaukee, WI, United States; 2 Neurology, School of Clinical Medicine, Southeast University,
Nanjing, Jiangsu, China
The purpose of this study was to identify neural correlates of depressive symptoms and memory deficits in the amygdala functional connectivity network
(AFCN) in elderly with or without amnesic mild cognitive impairment (aMCI) using the resting state functional connectivity MRI technique. aMCI subjects
showed abnormal AFCN activity and the significant different correlation patterns in the distinct nodes within the AFCN correlated to depressive symptoms
and memory deficits. This suggests the AFCN has dual effects that link depressive symptoms and memory deficits. The altered neural substrates of the
AFCN underlying the emotional and cognitive functions mediation were associated with disease state.
1997. Assessing the Effect of Age on Voxel-Based Relaxometry of Epileptic Patients
Rachel Sharkey 1,2 , Robert Karl Kosior, 1,3 , Paolo Federico 1,2 , Richard Frayne, 12
1 Seaman Family MR Research Centre, Foothills Medical Centre, Calgary, AB, Canada; 2 Radiology and Clinical Neurosciences,
Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada; 3 Biomedical Engineering, University of Calgary, Calgary, AB,
Canada
Our objective was to assess the effect of age on T2 for voxel-based relaxometry (VBR) analysis. Regressions of T2 versus age were run on data from healthy
controls with a voxel-based analysis and with regions of interest. For controls and epileptic patients, VBR was performed once with age included as a
nuisance variable, and once without. The correlation was variable across the brain, and significant (p < 0.05) in four regions, including the hippocampus
(decreasing T2 with age). Without adjusting for age, discrepancies in VBR findings are found in younger and older patients.
Normal Aging Brain
Hall B Wednesday 13:30-15:30
1998. A Multiparametric Study of White Matter Integrity and Cognition in Old Age
Susana Muñoz Maniega 1 , Lars Penke 2 , María C. Valdés Hernández 1 , Catherine Murray 2 , Natalie A.
Royle 1 , Alan J. Gow 2 , Jonathan D. Clayden 3 , John M. Starr 4 , Mark E. Bastin 5 , Ian J. Deary 2 , Joanna M.
Wardlaw 1
1 Clinical Neurosciences, University of Edinburgh, Edinburgh, United Kingdom; 2 Psychology, University of Edinburgh, Edinburgh,
United Kingdom; 3 Institute of Child Health, University College London, London, United Kingdom; 4 Geriatric Medicine, University of
Edinburgh, Edinburgh, United Kingdom; 5 Medical Physics, University of Edinburgh, Edinburgh, United Kingdom
Using diffusion MRI tractography we segmented white matter tracts thought to be related with cognition in a cohort of healthy older people. We registered
the tract segmentations to parametric maps of magnetization ratios and T1 relaxation times and used these parameters, as well as fractional anisotropy and
mean diffusivity, to characterise the white matter integrity of the tracts. The study of how tract integrity relates to cognition in old age revealed new
relationships not shown by diffusion parameters only. This work suggests that a multi-parameter approach could unravel the effects of ageing on the brain
and cognition better than the lone use of diffusion MRI.