TRADITIONAL POSTER - ismrm

Poster Sessions
2157. Glutamate Levels in the Anterior Cingulate Cortex Correlate with Self-Reported Impulsivity in
Patients with Borderline Personality Disorder and Healthy Controls
Mareen Hoerst 1,2 , Wofgang Weber-Fahr 1 , Nuran Tunc-Skarka 1 , Matthias Ruf 1 , Martin Bohus 2 , Christian
Schmahl 2 , Gabriele Ende 1
1 Department of Neuroimaging, Central Institute of Mental Health, Mannheim, Germany; 2 Department of Psychosomatic Medicine and
Psychotherapy, Central Institute of Mental Health, Mannheim, Germany
Dysfunction and deficits in the structure of the anterior cingulate cortex (ACC) have been reported in borderline personality disorder (BPD). Impulsivity
belongs to the key features of BPD and can be related to ACC function. In this study we found significantly increased self-reported impulsivity and higher
levels of glutamate in the anterior cingulate cortex in subjects with BPD as compared to healthy controls. In both groups the ACC glutamate concentrations
were positively correlated with self-reported impulsivity.
2158. Grey Matter Abnormalities in Adult Attention Deficit/hyperactivity Disorder as Measured with
Structural MRI
Natalia del Campo 1,2 , Julio Acosta-Cabronero 3,4 , Samuel R. Chamberlain, Dowson Jonathan 5 , Tim D.
Fryer, 4 , Trevor W. Robbins, Barbara J. Sahakian 5 , Ulrich Muller
1 Psychiatry, University of Cambridge, Cambridge, Cambs, United Kingdom; 2 2Behavioural and Clinical Neuroscience Institute,
Cambridge, Cambs, United Kingdom; 3 Department of Clinical Neurosciences, University of Cambridge, Cambridge, United
Kingdom; 4 Wolfson Brain Imaging Centre; 5 Department of Psychiatry
Attention deficit/hyperactivity disorder (ADHD) is the most prevalent psychiatric disorder in children. To date, little is known about the persistence and
stability of anatomical changes in ADHD across the lifespan. 16 adult ADHD patients and 17 healthy controls undertook structural magnetic resonance
imaging. Using cluster-based permutation analysis we found that ADHD patients had reduced grey matter density in distributed circuitries including the
right inferior and middle frontal cortex, as well as bilateral putamen, hippocampus, amygdala and cerebellum. These findings add to a growing body of
evidence implicating abnormalities in fronto-striatal, fronto-cerebellar and limbic circuitries in ADHD.
2159. A Systematic Analysis of Association Fiber Tracts in Chronic Alcoholics Found Significant Deficit of
White Matter Integrity in Superior Longitudinal Fasciculus Using Diffusion Spectrum Imaging Tractography
Cheng-Liang Liu 1 , I-Chao Liu 2 , Wen-Yang Chiang 3 , Fang-Cheng Yeh 4 , Li-Wei Kuo 1 , Wen-Yih Isaac
Tseng 1,5
1 Center for Optoelectronic Biomedicine, National Taiwan University College of Medicine, Taipei, Taiwan; 2 School of Medicine, Fu
Jen Catholic University, Taipei, Taiwan; 3 The Methodist Hospital Research Institute, Weill Medical College of Cornell University,
Houston, TX, United States; 4 Department of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA, United States;
5 Department of Medical Imaging, National Taiwan University Hospital, Taipei, Taiwan
In this study, we investigated the relationship between the effect of alcoholic use and the microstructural alteration of seven association fiber tracts using
diffusion spectrum imaging tractography and tract-specific analysis. The metric of generalized fractional anisotropy (GFA) was used to identify the
difference between control and alcoholic groups. Among all the association fiber tracts, a significant GFA deficit was found in bilateral superior longitudinal
fasciculus for chronic alcoholics. A future study to analyze the segmented parts of the tract is needed to further reveal the subtle change of microstructural
alteration of association fiber tracts in alcoholism.
2160. Frontal White Matter Choline-Containing Compounds Increase with Alcohol Consumption and
Glutamate Decreases with Increasing Addiction Criteria
Gabriele Ende 1 , Derik Hermann 2 , Mareen Hoerst 1 , Nuran Tunc-Skarka 1 , Gunilla Oberthuer 1 , Svenja
Wichert 2 , Juri Rabinstein 2 , Wolfgang Weber-Fahr 1 , Karl Mann 2 , Sabine Vollstaedt-Klein 2
1 Neuroimaging, Central Institute of Mental Health, Mannheim, Germany; 2 Addiction Medicine, Central Institute of Mental Health,
Mannheim, Germany
With this 1H MRS study we aimed to investigate correlations between frontal white matter choline-containing compounds and glutamate with alcohol
consumption and addictions scores in heavy drinking as well as in non-abstinent alcohol dependent patients. A positive correlation of choline-containing
compounds and alcohol consumption could be replicated but the high variance could not be explained by addiction criteria (OCDS, ICD-10 and DSM IV).
However, measures of addiction showed significant negative correlations with glutamate in the heavy drinking groups.
2161. Test and Retest of the Emotional Responses in Adolescents Prenatally Exposed to Cocaine
Zhihao Li 1 , Priya Santhanam 1 , Claire D. Coles 2 , Mary Ellen Lynch 2 , Stephan Hamann 3 , Xiaoping Hu 1
1 Biomedical Engineering, Emory Univ. & Georgia Tech., Atlanta, GA, United States; 2 Psychiatry and behavioral Science, Emory
Univ., Atlanta, GA, United States; 3 Psychology, Emory Univ., Atlanta, GA, United States
The present fMRI study examined the interaction effect of prenatal cocaine exposure (PCE) and development on brain activations associated with emotional
arousal, in adolescents. Comparing age 17 to 15, cortical responses elicited by negative emotional stimuli are reduced in the controls but remain roughly the
same in the PCE adolescents. The present results suggest a long-term and stable PCE effect on emotional arousal regulation.