TRADITIONAL POSTER - ismrm

Poster Sessions
ethanolamine compound was clearly significant (p=0.02). Further, the significant increase in the inorganic-phosphate/phosphocreatine ratio hints to limited
energy supply within the tumor.
2207. Comparison of in Vivo MRS Glutamate/Glutamine Levels in Tumor-Associated Epilepsy
Christopher Steward 1 , Bradford Moffat 1 , Tanya Yuen 2 , Terence O'Brien 2 , Patricia Desmond 1 , Andrew
Morokoff 3 , Chris Kokkinos 4
1 Radiology, University of Melbourne, Melbourne, VIC, Australia; 2 Medicine, University of Melbourne, Melbourne, VIC, Australia;
3 Surgery, University of Melbourne, Melbourne, VIC, Australia; 4 Radiology, Royal Melbourne Hospital, Melbourne, VIC, Australia
The pathogenesis of tumour associated seizures (TAS), a common co-morbidity with brain tumors remains poorly understood. Glutomate has been
implicated in many types of epilepsy. In a pilot study the concentration of glutamate/glutamine associated with gliomas using in vivo MRS was studied, and
correlated with observed pre-operative seizures. Elevated glutamate/glutamine levels were found in the peritumoral area of tumours who experienced preoperative
seizures compared to those which did not. Due to the small sample size, we are in the process of acquiring a larger MRS and ex vivo prospective
data set (N>100) to confirm these findings.
2208. Interpreting Fractional Anisotropy in Gliomas: Correlation with 1H Spectroscopy and Consideration
of SNR
Franklyn Arron Howe 1 , Tom R. Barrick 2 , Greg A. Fellows 3 , Alan J. Wright 4
1 Cardiac & Vascular Sciences , St George's, University of London, London, United Kingdom; 2 Clinical Neuroscience, St George's,
University of London, London, United Kingdom; 3 Academic Neurosurgery, St George's, University of London, London; 4 Radiology,
UMC st. Radboud University Hospital, Nijmegen, Netherlands
Metabolic information from 1H MRSI may aid image segmentation using DTI and so improve delineation of infiltrative brain tumours such as gliomas.
NAA and fractional anisotropy (FA) are expected to decrease with tumour infiltration and loss of neuronal structure, but FA calculated from principal
diffusion magnitude images is biased due to the contribution of noise. We have investigated the FA and NAA distribution in glioblastomas in comparison to
simulated data that takes into account the effect of SNR on the measurement of low FA values. Our data provides evidence for diffusion anisotropy in
glioblastomas in the absence of functional neurones.
2209. 5 Year Longitudinal Mri Follow-Up and 1H Single Voxel Mrs in 13 Patients with Gliomatosis Treated
with Temodal, Radiotherapy and Antiangiogenic Therapy.
Jean-Marc Constans 1,2 , François Kauffmann 3 , Gabriela Hossu 4 , Weibei Dou 5 , Jean-Michel Derlon 6 ,
Emmanuelle Lechapt-Zalcmann 7 , Samuel Valable 8 , Jean-Sebastien Guillamo 9,10
1 MR Unit, CHU de CAEN, CAEN, Normandy, France; 2 CERVOxy, Cyceron- CI-NAPS- CNRS , CAEN, Normandy, France;
3 LMNO- UMR 6139, CNRS, CAEN, France; 4 UMR 947, CIC-IT et INSERM, Nancy, France; 5 Electronic, Tsinghua University,
Beijing, China; 6 CHU de Caen, CAEN, France; 7 CHU de Caen, Caen, France; 8 Cyceron CINAPS CNRS UMR 6232, CAEN, France;
9 CHU CAEN, France; 10 CERVOxy, Cyceron CNRS CI-NAPS, CAEN, France
MRS with Cho/Cr, mI/Cr and NAA/Cr ratios, could be more sensitive than MRI and could, in some cases, be predictive of worsening in gliomatosis followup.
These spectroscopic changes occurred well before clinical deterioration. There is a large variability, but repetition and modelisation of spectroscopic
measurements during longitudinal follow-up could allow us to diminish it and to improve gliomatosis prognostic evaluation.
Studying the relationship between MRS measures, methionine PET, segmentation and perfusion parameters could lead to better understanding of therapeutic
response, especially with regard to chemotherapy and antiangiogenic molecules and in the future hypoxia modulators.
2210. Prominent Citrate Predicts Malignant Progression of Low-Grade Astrocytomas in Children
Arabhi C. Nagasunder 1 , Mikhail Laskov 2 , Albert Joseph 2 , Ashok Panigrahy 1,3 , Girish Dhall 2 , Jonathan L.
Finlay 2 , Ignacio Gonzalez-Gomez 4 , Mark D. Krieger 5 , Marvin D. Nelson 1 , Stefan Bluml 1,6
1 Department of Radiology, Childrens Hospital Los Angeles, Los Angeles, CA, United States; 2 Childrens Center for Cancer and Blood
Diseases, Childrens Hospital Los Angeles, Los Angeles, CA, United States; 3 Department of Radiology, Childrens Hospital of
Pittsburgh of UPMC, Pittsburgh, PA, United States; 4 Department of Neuropathology, Childrens Hospital Los Angeles, Los Angeles,
CA, United States; 5 Department of Neurosurgery, Childrens Hospital Los Angeles, Los Angeles, CA, United States; 6 Rudi Schulte
Research Institue, Santa Barbara, CA, United States
Pediatric low-grade gliomas can either progress to a high-grade lesion or remain dormant for long periods of time. Currently, there is a need to identify
markers that would allow pediatric neuro-oncologists to predict tumor progression. Our goal was to determine whether aggressive pediatric low-grade II
astrocytoma have metabolic features that distinguishes them from stable grade II astrocytoma using in vivo MR Spectroscopy. We found that elevated citrate
and low NAA may predict malignant progression of low-grade astrocytomas.