TRADITIONAL POSTER - ismrm

Poster Sessions
training had a significant effect in suppressing head motion: (1) 11.25 mm before, 0.83 mm after; (2) 1.63 mm before, 0.67 mm after; (3) 4.47 mm before,
0.51 mm after.
1107. Scan Time Reduction in FMRI Using a 32 Channel Phased Array Receive Coil
Christina Triantafyllou 1,2 , Sheeba Arnold 1 , Steven Shannon 1 , John Gabrieli 3 , Susan Whitfield-Gabrieli 3
1 A.A. Martinos Imaging Center, McGovern Institute for Brain Research, MIT, Cambridge, MA, United States; 2 A.A. Martinos Center
for Biomedical Imaging, Department of Radiology, MGH, Charlestown, MA, United States; 3 Department of Brain and Cognitive
Sciences, MIT, Cambridge, MA, United States
Long durations in fMRI are typical, but that is unfeasible for specific populations. Scan-time reduction is possible if one could capitalize on the increased
sensitivity afforded by high field strength or multiple channel phased arrays in the high-resolution regime. We evaluated this using a 32-channel coil at 3T
with the n-back task on 18 subjects. Compared to 12-channel coil, working memory activation was significantly more (paired t-test) with two-thirds of the
32-channel data. Combination of 32-channel coil and high-resolution could imply lesser sample size, prevent additional data collection and enable studies
that would otherwise be impossible due to time restrictions.
1108. Multi-Sequence Comparison of Temporal Lobe FMRI Activation at 4.0 T
Lindsay Cherpak 1,2 , Kimberly Brewer 1,2 , Jodie Gawryluk 1,3 , Nicole Pelot 1,2 , Chris Bowen 1,4 , Ryan D'Arcy 1,3 ,
Steven Beyea 1,4
1 Institute for Biodiagnostics (Atlantic), National Research Council of Canada, Halifax, Nova Scotia, Canada; 2 Physics and
Atmospheric Science, Dalhousie University, Halifax, Nova Scotia, Canada; 3 Psychology, Dalhousie University, Halifax, Nova Scotia,
Canada; 4 Physics and Atmospheric Science, Radiology and Biomedical Engineering, Dalhousie University, Halifax, Nova Scotia,
Canada
This study involved a comprehensive evaluation of commonly-used techniques like EPI and spiral-out, as well as techniques designed to recover signal in
SFG regions using BOLD methods (spiral-in, spiral-in/out, spiral-in/in and ASE spiral) and non-BOLD methods (FAIR and spin-echo spiral-in/out) at 4.0 T.
A cognitive task used to evaluate temporal lobe epilepsy patients was presented to elicit activation in the inferior temporal lobe (as well as other brain
regions). Notably, this work allowed us to examine the differing effects that the contrast and signal recovery mechanisms have on fMRI activation in both
SFG and non-SFG regions.
1109. Time Resolved FMRI: 100 Ms Resolution in Time for Extended Network Analysis of the Human Brain
Julia Reinhardt 1,2 , Ernst Nennig 3 , Stephan Walther 4 , Sabine Heiland 2 , Christoph Stippich 1,2
1 Department of Neuroradiology, University of Basel Hospital, Basel, Switzerland; 2 Division of Neuroradiology, Department of
Neurology, University of Heidelberg, Medical Center, Heidelberg, Germany; 3 OptiMed Medizinische Instrumente GmbH, Ettlingen,
Germany; 4 Center for Psychosocial Medicine, General Psychiatry, University of Heidelberg, Medical Center, Heidelberg, Germany
Until now the temporal resolution in fMRI was mostly restricted by the used TR. Employing a new method to enhance the time resolution in fMRI below
100 ms we are able to trace neuronal network pathways with extremely short reaction times. The temporal dynamics of somatosensory processing could be
measured and correspond with the known values from electrophysiological measures. With this new approach BOLD-fMRI enables to study the temporal
dynamics of cortical processing with a temporal resolution of 10 ms.
1110. Evaluating Feraheme as a Potential Contrast Agent for Clinical IRON FMRI
Joseph B. Mandeville 1 , Krishna Srihasam 2 , Wim Vanduffel 1 , Margaret S. Livingstone 2
1 Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, United States; 2 Department of
Neurobiology, Harvard Medical School, Boston, MA, United States
Feraheme is a newly FDA-approved drug for treating chronic iron anemia in clinical populations. The approved iron dose of 510 mg falls within a weightnormalized
range of 5-10 mg/kg for human subjects within the range 50-100 kg. To evaluate this drug as a potential contrast-enhancing agent for human
clinical fMRI, we performed experiments in awake non-human primates at 3 Tesla to validate theoretical calculations. Results suggest that this agent could
enhance the CNR ratio of clinical fMRI by factors of 5 and 2.5 and 1.5 at 3 Tesla, respectively.
1111. Reproducibility of T1 and Tissue Fractional Volume Mapping Using FRASIER: An Application to
FMRI Settings
Wanyong Shin 1 , Hong Gu 1 , Yihong Yang 1
1 Neuroimaging Research Branch, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD, United States
Recently, FRActional Signal mapping from InvErsion Recovery (FRASIER) was proposed to map T1 and tissue fractional volume in the brain. In this study
we incorporated FRASIER into an fMRI protocol and assessed the reproducibility of the technique. Using FRASIER, 15 slice T1 and fractional volume
maps were acquired in every 10 seconds with 64¡¿64 matirx size. Standard deviations of the T1 and fractional volume maps was within 37ms and 3.5% in
this study, demonstrating feasibility of FRASIER in fMRI settings.
1112. Functional MRI on an Open 1.0 T MRI Scanner: A Comparison with a State-Of-The-Art 3.0 T MRI
Scanner
Elsmarieke van de Giessen 1 , Paul F.C. Groot 2 , Jan Booij 1 , Wim van den Brink 3 , Dick J. Veltman 3 , Aart J.
Nederveen 2
1 Nuclear Medicine, Academic Medical Center, Amsterdam, Netherlands; 2 Radiology, Academic Medical Center, Amsterdam,
Netherlands; 3 Amsterdam Institute for Addiction Research, Academic Medical Center, Amsterdam, Netherlands
This study is the first, to our knowledge, that tests the feasibility of fMRI on an open MRI system, with a magnetic field strength of 1.0 T, and compares the
results with fMRI on a state-of-the-art 3.0 T MRI scanner. The optimal echo time for fMRI on an open 1.0 T MRI system was found to be around 70 ms.
Results show that fMRI on an open 1.0 T MRI scanner is feasible for studies that are designed to analyze data at a group level, though not optimal for studies
on single subjects.