TRADITIONAL POSTER - ismrm

Poster Sessions
1252. High Resolution 3D Black Blood Carotid Artery Imaging Using 3D TSE Sequence with Non-Selective
Refocusing RF and Inner Volume Imaging Technique.
Seong-Eun Kim 1,2 , Scott McNally 2 , Laura K. Findeiss 2 , Jordan Hulet 3 , John Roberts 1,2 , Eun-Kee Jeong 1,2 ,
Dennis L. Parker 1,2 , Gerald S. Treiman 4,5
1 UCAIR, University of Utah, Salt Lake City, UT, United States; 2 Department of Radiology, University of Utah, Salt Lake City, UT,
United States; 3 Department of Biomedical Informatics, University of Utah; 4 Department of Surgery, University of Utah, Salt Lake
City, UT, United States; 5 Veterans Affair, VASLCHCS, Salt Lake City, UT, United States
2D TSE with DIR is the current technique for identification of the component of carotid plaque. This approach is limited by inadequate spatial resolution
that is often necessary to identify small areas of plaque components. 3D imaging offers the potential to improve spatial resolution. We have utilized 3D TSE
with non-selective 180o RF and have implemented an inner volume imaging(IVI) technique. The non-selective 180o RF allow significantly more echoes to
be acquired resulting in more efficient 3D scan. IVI technique reduces the field of view in the phase encoding direction and requires fewer phase encoding
line, further reducing scan time.
1253. Intravascular 3.0T MR Imaging: A Feasibility Study in Swine
Yanfeng Meng 1,2 , Feng Zhang 1 , Huidong Gu 1 , Jinnan Wang 3 , Chun Yuan 1 , Zhaoqi Zhang 2 , Bensheng Qiu 1 ,
Xiaoming Yang 1
1 Radiology, University of Washington, Seattle, WA, United States; 2 Radiology, Beijing Anzhen Hospital, Beijing, China; 3 Clinical
Sites Research Program, Philips Research North America, Briarcliff Manor, NY, United States
This study was to validate the feasibility of generating intravascular 3T MRI of deep-seated arteries of near-human-sized swine by using a 3T-MR
compatible MR-imaging guidewire (MRIG). For in vitro testing, we compared SNRs generated by a 0.032-inch MRIG and surface coils. For in vivo
validation, we performed intravenous MRI of the parallel-run iliofemoral arteries with this MRIG. The SNR by the MRIG was higher than surface coils, and
the iliofemoral arterial walls were clearly delineated with the MRIG at a higher SNR than surface coils. This study establishes the groundwork for further
intravascular 3T MRI of deep-seated arteries in humans.
1254. Histology Assisted Validation of Automatic Detection of Soft Plaque in Vessel Wall Images by Using
Optimal Number of MR Sequences
Ronald van 't Klooster 1 , Andrew J. Patterson 2 , Victoria E. Young 2 , Jonathan H. Gillard 2 , Johan H.C.
Reiber 1 , Rob J. van der Geest 1
1 Division of Image Processing, Department of Radiology, Leiden University Medical Center, Leiden, Netherlands; 2 University
Department of Radiology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom
Extensive MR vessel wall imaging protocols are used to identify unstable plaques, which play an important role in the progression of atherosclerosis.
Comparison was made between automatic plaque detection, by a supervised classification system, and histology assisted manual segmentation. Experiments
show that the automatic detection of unstable plaque is in good agreement with the manual segmentation. Moreover, the STIR and DWI sequences show an
improvement over the T2w and PDw sequences. Automatic detection of soft plaque may be feasible by using a limited number of MR sequences, saving
both MRI system and image analysis time.
1255. Improved Calcification Detection Accuracy on Human Atherosclerotic Plaque Using Ultra-Short TE
(UTE) Imaging
Jinnan Wang 1 , Marina S. Ferguson 2 , Niranjan Balu 2 , Chun Yuan 2 , Peter Boernert 3
1 Clinical Sites Research Program, Philips Research North America, Seattle, WA, United States; 2 University of Washington; 3 Philips
Research Europe
Ultra-short TE (UTE) images can provide positive contrast for short T2 species when combined with imaging techniques like dual-echo subtraction or
magnetization preparation. Although the calcified regions identified on UTE images were demonstrated to agree with CT images, its accuracy has not been
validated against histology. This study is aimed at comparing the accuracy of UTE calcification detection in human carotid plaques against regular turbo spin
echo MR images, as well as validating it against histology.
1256. Response of the Carotid Vessel Wall to Lipid-Lowering Therapy: Time Course of T1 and T2-Weighted
Signal Variation
Li Dong 1 , William Sean Kerwin 1 , Chun Yuan 1 , Xue-Qiao Zhao 1
1 University of Washington, Seattle, WA, United States
We hypothesized that lipid-lowering therapy leads to biological changes in arterial walls that result in altered MRI contrast, even in the absence of a
developed necrotic core. In a carotid MRI study of atorvastatin, 42 subjects exhibited no necrotic core. Within this group, no measurable change in wall
thickness occurred over 3 years, but a highly significant (p