TRADITIONAL POSTER - ismrm

Poster Sessions
1974. 31P and 1H MR Spectroscopic Studies on Changes of Cerebral Brain Metabolism Induced by
Alcoholism and Detoxification
Ulrich Pilatus 1 , Joerg Magerkurth 1 , Nicole Schwan 2 , Tilmann Wetterling 2 , Barbara Schneider 2
1 Institute of Neuroradiology, University Hospital, Goethe-University, Frankfurt, Germany; 2 Department of Psychiatry, University
Hospital, Goethe-University
Cerebral metabolites at day 1 and day 7 of alcohol detoxification therapy were studied using 1H and 31P spectroscopic imaging. Particularly for prefrontal
brain, metabolite concentrations correlated with the withdrawal syndrome. The results suggest that less severe symptoms support neuronal recovery while a
less pronounced deviation from control values for energy or membrane related compounds is correlated with more severe symptoms.
1975. Schizophrenia Impact on Perfusion Parameters: A Dynamic Susceptibility Contrast Magnetic
Resonance Imaging Study.
Denis Peruzzo 1 , Gianluca Rambaldelli 2,3 , Alessandra Bertoldo 1 , Marcella Bellani 2,3 , Roberto Cerini 4 , Sivlia
Marini 5 , Roberto Pozzi Mucelli 5 , Michele Tansella 2,3 , Paolo Brambilla 6,7
1 Department of Information Engineering, University of Padova, Padova, Italy; 2 Inter-University Center for Behavioural
Neurosciences, University of Verona, Verona, Italy; 3 Department of Medicine and Public Health, University of Verona, Verona, Italy;
4 Service of Radiology, Policlinico GB Rossi Hospital, Verona, Italy; 5 Department of Morphological and Biomedical Sciences,
University of Verona, Verona, Italy; 6 Inter-University Center for Behavioural Neurosciences, University of Udine, Udine, Italy;
7 Scientific Institute, IRCCS “E. Medea”, Udine, Italy
Abnormalities of Cerebral Blood Flow (CBF) and Volume (CBV) have been observed in schizophrenia patients, suggesting that a disruption of the vascular
system may occur in this disease. However, cerebral perfusion is also influenced by several physiologic parameters, not necessarily connected to the
pathology. We performed a DSC-MRI analysis to study the role of the demographic information on perfusion parameter estimates between patients with
schizophrenia and normal control subjects. We found that differences (i.e. between-subject variability) in CBF and CBV are partially explained by the age
and/or by a difference in the subject health conditions.
none
1976. Early Magnetic Resonance Spectroscopy Renormalized of Prefrontal Cortex and Anterior Cingulated
Cortex Metabolites in Hepatic Encephalopathy After Liver Transplantation
Haiyan Lou 1 , Desheng Shang 2 , Minming Zhang 1
1 Department of Radiology, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China;
2 Department of Radiology, The First Affiliated Hospital, Hangzhou, Zhejiang, China
1977. ARV-Mediated Changes in Viral Levels and Neuroaxonal Function Precede Improvements in
Cognition in Chronically HIV-Infected Subjects.
Margaret R. Lentz 1 , Mona A. Mohamed 2,3 , Hyun Kim 1 , Jennifer A. Short 1 , Mahaveer N. Degaonkar 2 , Elkan
Halpern 1 , Katherine Conant 4 , Ned Sacktor 5 , Ola Selnes 5 , Peter B. Barker 2,3 , Martin G. Pomper 2
1 Department of Neuroradiology/A. A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston, MA, United
States; 2 Russell H. Morgan Department of Radiology and Radiological Sciences, Johns Hopkins Medical Institutions, Baltimore, MD,
United States; 3 F. M. Kirby Center for Functional Brain Imaging/Kennedy Krieger Institute, Johns Hopkins Medical Institutions,
Baltimore, MD, United States; 4 Department of Neuroscience, Georgetown University Medical Center, Washington, DC, United
States; 5 Department of Neurology, Johns Hopkins Medical Institutions, Baltimore, MD, United States
The application of combined antiretroviral (ARV) therapy has been shown to change viral and immune signaling kinetics, indicating that correlations
between these and MR measures observed in cross-sectional studies may not last. MRSI, global deficit scorings (GDS) and CSF HIV RNA levels of 51
chronically HIV-infected subjects examined over 10 months of a new ARV administration were included in this study. Mixed model regression analysis
indicated that later improvements in subjects’ GDS were associated with earlier improvements in neuroaxonal function and CSF viral load, suggesting that
ARV-mediated decreases in CSF viral levels and neuroaxonal recovery precede improvements in cognitive functioning.
1978. Hippocampus Perfusion Studies of Gulf War Veterans Using OPTIMAL FAIR
Xiufeng Li 1 , Subhendra N. Sarkar 2 , David E. Purdy 3 , Qihua Lin 4,5 , David M. Buhner 5 , Robert W. Haley 5 ,
Richard W. Briggs 1,5
1 Radiology, UT Southwestern, Dallas, TX, United States; 2 Radiology, Beth Israel Deaconess Medical Center, Boston, MA, United
States; 3 Siemens Healthcare, Malvern, PA, United States; 4 Clinical Sciences, UT Southwestern Medical Center, Dallas, TX, United
States; 5 Internal Medicine, UT Southwestern Medical Center, Dallas, TX, United States
To verify the previous findings and facilitate futher investigation of the pathological characteristics of Gulf War Illness, a semi-blind hippocampus perfusion
study with physostigmine challenge was performed for veterans with Gulf War Syndromes 1, 2 and 3 and healthy veterans in two sessions two days apart:
the first session with saline infusion and the second session with physostigmine infusion. New study results are similar to those found in the SPECT studies
performed in 1997-1998, indicating that the physiological effects upon hippocampal blood flow still persist a decade later.