TRADITIONAL POSTER - ismrm

Poster Sessions
2592. Flip Angle Optimization with Hepatobiliary Contrast Agents at 3T
Sharon Lisa D'Souza 1 , Alex P. Frydrychowicz 1 , Karl K. Vigen 1 , Scott K. Nagle 1 , Scott B. Reeder 2
1 Radiology, University of Wisconsin, Madison, WI, United States; 2 Radiology, Medical Physics, Biomedical Engineering, and
Medicine, University of Wisconsin, Madison, WI, United States
Gadolinium based contrast agents Gd-EOB-DTPA and Gd-BOPTA have hepatobiliary excretion and tremendous utility for liver lesion characterization and
biliary imaging with T1 weighted imaging. Unfortunately, most T1 weighted sequences are not optimized for maximizing CNR in delayed phase
hepatobiliary imaging. The purpose of this study was to perform flip angle optimization at 3.0T for delayed hepatobiliary phase imaging as part of a crossover
study comparing Gd-EOB-DTPA and Gd-BOPTA. Data show that imaging at 40-45° FA with 0.05mmol/kg Gd-EOB-DTPA at 20 minutes and 20-25°
FA with 0.1mmol/kg Gd-BOPTA provides optimal CNR behavior to visualize the liver and bile ducts.
2593. Effects of a Single Intravenous Dose of Estradiol-17β D-Glucuronide on Biliary Excretion: Assessment
with Gadoxetate DCEMRI
Jose Ulloa 1 , Simone Stahl 2 , Carsten Liess 1 , Jonathan Bright 3 , Angela McDermott 2 , Neil Woodhouse 1 , Jane
Halliday 1 , Arvind Parmar 1 , Guy Healing 2 , Gerry Kenna 2 , Andrew Holmes 1 , Hervé Barjat 1 , John Waterton 1 ,
Paul Hockings 1
1 Translational Sciences, Astrazeneca, Macclesfield, Cheshire, United Kingdom; 2 Safety Assessment, Astrazeneca, Macclesfield,
Cheshire, United Kingdom; 3 Discovery Statistics, Astrazeneca, Macclesfield, Cheshire, United Kingdom
Cholestasis is an important mechanism that can result in drug induced liver injury, a recurrent cause of attrition of new drug candidates. In rats, transporters
Oatp1 and Mrp2 mediate liver uptake and clearance of gadoxetate, a hepatobiliary contrast agent used to characterise focal liver lesions. Estradiol-17β D-
glucuronide (E 2 17G) induces acute but transient cholestasis in rats through impairment of Mrp2 and Bsep function. The aim of this work was to assess
whether characterisation of the kinetics of gadoxetate excretion can detect transient cholestasis induced by E 2 17G. Results suggest this method can be used
to investigate inhibition of transporters mediating biliary excretion.
2594. 3D-Liver Perfusion MR Imaging with MS-325 Blood Pool Contrast Agent to Evaluate Liver Fibrosis
Benjamin Leporq 1 , Olivier Beuf 1 , Denis Grenier 1 , Frank Pilleul 2
1 Université de Lyon, Creatis-LRMN, CNRS UMR 5220, Inserm U630, INSA-Lyon, Université Lyon 1, Villeurbanne, France;
2 Université de Lyon, Creatis-LRMN, CNRS UMR 5220, Inserm U630, INSA-Lyon, Université Lyon 1, Hospices Civils de Lyon,
Lyon, France
Liver fibrosis is an important cause of mortality and morbidity in patients with chronic liver. A non invasive technique to perform an early detection and a
clinical follow-up of liver fibrosis is still needed. The objectives of this study was to evaluate estimated-perfusion parameters based on 1.5T-MR dynamic
acquisition with the MS-325 paramagnetic blood pool agent for liver fibrosis diagnosis in comparison with histological findings. Dynamic 3D MRI was
performed with a continuous free-breathing acquisition followed by a rigid-images registration. A 5-parameters dual input one compartment model was used
to estimate quantitative perfusion parameters. Sixteen patients with chronic liver diseases were prospectively enrolled. Hepatic Perfusion Index and portal
blood flow were found relevant parameters to discriminate between F2, F3 and F4 METAVIR stages (p