TRADITIONAL POSTER - ismrm

Poster Sessions
1055. A Hydraulic Driver System for MR Elastography of Small Animals
Michael Neumaier 1 , Elmar Schuck 2 , Thomas Kaulisch 1 , Heiko G. Niessen 1 , Dieter Klatt 3 , Ingolf Sack 3 ,
Juergen Braun 4 , Detlef Stiller 1
1 In-Vivo Imaging Unit, Dept. of Drug Discovery Support, Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach, BW, Germany;
2 Precision Mechanics, Dept. of Site Operations, Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach, BW, Germany; 3 Dept. of
Radiology, Charité - University Medicine Berlin, Berlin, Germany; 4 Dept. of Medical Informatics, Charité - University Medicine
Berlin, Berlin, Germany
MR elastography (MRE) is a powerful tool for the non-invasive assessment of liver diseases. It requires the reliable delivery of shear waves in the acoustic
frequency range between 25 and 1000 Hz. We present a novel concept of motion generation suitable for MRE of small animals based on a piezoelectric
wave generator and a hydraulic transmission system. The new system provides excellent wave penetration of rat liver in the desired frequency range and
yields reproducible and consistent results.
1056. Detecting Breast Phantom Lesions with Acoustic Radiation Force in MR Images: Experiment and
Finite-Element Simulations
Jessica Mende 1 , Marcus Radicke 1 , Anna-Lisa Kofahl 1 , Judith Schindler 1 , Deniz Ulucay 1 , Jürgen
Finsterbusch 2 , Bernd Weber 3 , Karl Maier 1
1 HISKP, University of Bonn, Bonn, Germany; 2 University Medical Center, University of Hamburg, Hamburg, Germany;
3 NeuroCognition, Life & Brain, Bonn, Germany
Acoustic radiation contrast in magnetic resonance phase images is a recently developed method to image and quantify non-invasively the viscoelastic
properties of tissue. A displacement sensitive MRI spin-echo sequence was used to image the displacement caused by the acoustic radiation force of
ultrasound with a frequency of 2.5 MHz, a pulse length of 20 ms and an intensity of 35 W/cm 2 . To show the feasibility of this method, results of the
detection of lesions in a breast elastography phantom are presented. Finite-element simulations show good agreement with the experimental data.
1057. Tissue Stiffness Estimation Using Gaussian Filters for Prostate MR Elastography
Frank Zhao 1 , Arvin Arani 1,2 , Don Plewes 1,2 , Rajiv Chopra 1,2
1 Imaging Research, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada; 2 Medical Biophysics, University of Toronto,
Toronto, Ontario, Canada
Transurethral MR elastography offers the potential to obtain high resolution stiffness images of the prostate gland. The purpose of this study was to adapt the
local frequency estimator algorithm for the radial shear wave geometry associated with this approach. The stiffness estimates were compared between the
conventional and modified LFE method.
1058. Acoustic Radiation Contrast in Magnetic Resonance: Detection of Microcalcifications
Judith Schindler 1 , Deniz Ulucay 1 , Jessica Mende 1 , Marcus Radicke 1 , Anna-Lisa Kofahl 1 , Jürgen
Finsterbusch 2 , Robert Krieg 3 , Karl Maier 1
1 HISKP, University of Bonn, Bonn, Germany; 2 University Medical Center, University of Hamburg, Hamburg, Germany; 3 Siemens
Healthcare, Erlangen, Germany
One promising application of acoustic radiation contrast in magnetic resonance (ARC-MR) phase images is the detection of microcalcifications (tiny
abnormal deposits of calcium) in breast tissue. Acoustic radiation force was applied using a custom-made MR-compatible piezoelectric transducer with a
resonance frequency of 2,5 MHz. The thus produced displacement in the phantom was made visible with a displacement sensitive spin-echo sequence. The
phantom was an agar/de-ionized water solution containing glass beads to get tissue-like ultrasound absorption. Results show that an eggshell (1mmx1mm)
that mimics the microcalcification is only visible in MR phase images when the ultrasound is turned on.
Drug Discovery
Hall B Wednesday 13:30-15:30
1059. Exploration of Resting State FMRI Metrics as Biomarkers of Central Nervous System Activation by
Drug: Placebo Controlled FMRI Study of the Effect of the Analgesic Buprenorphine
Alexandre Coimbra 1,2 , Richard Baumgartner, 2,3 , Dai Feng, 2,3 , Shubing Wang 3 , Jaymin Upadhyay, 2,4 ,
Adam Schwarz, 2,5 , Julie Anderson, 2,4 , Lauren Nutile, 2,4 , Gautam Pendse, 2,4 , James Bishop, 2,4 , Ed George,
2,4 , Smiriti Iyengar, 2,5 , David Bleakman, 2,5 , Richard Hargreaves, 2,6 , Jeff Evelhoch 1,2 , David Borsook, 2,4 ,
Lino Becerra, 2,4
1 Imaging, Merck Research Laboratories, West Point, PA, United States; 2 Imaging Consortium for Drug Development, Belmont, MA,
United States; 3 Biometrics, Merck Research Laboratories, Rahway, NJ, United States; 4 PAIN, McLean Group, Belmont, MA, United
States; 5 Lilly Research Laboratories, Indianapolis, IN, United States; 6 Neurosciences, Merck Research Laboratories, West Point, PA,
United States
It has been suggested that fMRI functional connectivity metrics may be useful tools to test efficacy of CNS therapeuticals. This work provides initial
exploration of functional connectivity approaches based on Independent Component Analysis. This is done in the context of a Placebo Controlled study of
Buprenorphine, a partial opioid agonist and antagonist. A set of previously reported fundamental resting state networks (RSNs) were examined comprising
of medial visual, lateral visual, auditory system, sensory motor system, default mode network, executive control, dorsal visual stream. Treatment effects of
Buprenorphine on functional connectivity metrics associated with each of these fundamental RSNs were examined.