TRADITIONAL POSTER - ismrm

Poster Sessions
1087. Quantitative Evaluation of FMRI Acquisition Strategies at 7T Using NPAIRS
Robert L. Barry 1,2 , J Christopher Gatenby 1,2 , Allen T. Newton 1,2 , Stephen C. Strother 3,4 , John C. Gore 1,2
1 Vanderbilt University Institute of Imaging Science, Vanderbilt University, Nashville, TN, United States; 2 Department of Radiology
and Radiological Sciences, Vanderbilt University, Nashville, TN, United States; 3 Rotman Research Institute of Baycrest, Toronto,
ON, Canada; 4 Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada
Although 2D single-shot EPI is common in BOLD fMRI, recent studies have suggested that 3D multi-shot sequences such as PRESTO-SENSE may offer
superior BOLD CNR through improved temporal efficiency. A four-way comparison was performed between 2D and 3D acquisition sequences at two voxel
resolutions (1.19x1.19x2 mm 3 and 2.19x2.19x2 mm 3 ) at 7T. The quality of fMRI data was evaluated via independent and unbiased metrics of prediction and
reproducibility using NPAIRS. Results suggest that EPI provides higher prediction and reproducibility for this study. Future work will investigate withinsubject
optimization, and further compare EPI with PRESTO-SENSE for an fMRI study requiring whole-brain coverage.
1088. The Effect of Parallel Imaging on the Sensitivity of BOLD Signal to Physiological Noise
Tomas Jonsson 1 , Tie-Qiang Li 1
1 Department of Medical Physics, Karolinska University Hospital, S-141 86, Stockholm, Sweden
The sensitivity to physiological noises of the reconstructed BOLD MR images is altered by the employed parallel imaging strategies. In this study, we
mapped and compared the physiological noise sensitivity of BOLD fMRI data acquired with and without employing parallel imaging at two different spatial
resolutions. Using higher spatial resolution reduces the signal strength and the relative sensitivity to physiological noise. This can be of SNR advantage
particularly for time series fMRI data acquired at higher magnetic field.
1089. Multi-Slice Two- And Four-Fold Acceleration with Single- And Eight-Channel Coils, Respectively
Andrzej Jesmanowicz 1 , Shi-Jiang Li 1 , James S. Hyde 1
1 Biophysics, Medical College of Wisconsin, Milwaukee, WI, United States
Complex-valued tailored pulses have been used in an EPI sequence to excite two or more slices in human brain using a whole-brain transmit coil. One or
more members of a receive-coil array have been used to acquire multi-channel image data. Complex-valued coil profiles have been used to recover slices,
and parallel image formation has been demonstrated. Acceleration by a factor of 4 has been achieved with an eight-channel head coil.
1090. Detecting Single Cortical Column Activation Under Super High Spatial Resolution at 9.4 T Using
Single-Shot Half K-Space GR-EPI
Rupeng Li 1 , Patrick Hettinger 2 , Younghoon Cho 1 , Christopher P. Pawela 1 , Ji-Geng Yan 2 , Andrzej
Jesmanowicz 1 , Anthony Hudetz 3 , Hani Matloub 2 , James Hyde 1
1 Biophysics, Medical College of Wisconsin, Milwaukee, WI, United States; 2 Plastic Surgery, Medical College of Wisconsin,
Milwaukee, WI, United States; 3 Anesthesiology, Medical College of Wisconsin, Milwaukee, WI, United States
Single-shot half k-space GR-EPI sequence was used to push the BOLD imaging resolution to 300 micron cubic voxel and unique single column cortical
activation in the sensory cortex was detected when stimulating the middle phalange of all 8 digits of rat.
1091. Development and Evaluation of Alternative Imaging Methods for FMRI at 7 Tesla
John Sexton 1,2 , Jascha Swisher 3 , Frank Tong 3 , Baxter Rogers 1,2 , J Christopher Gatenby 1,4 , John C. Gore 1,4
1 Vanderbilt University Institute of Imaging Science, Nashville, TN, United States; 2 Biomedical Engineering, Vanderbilt University,
Nashville, TN, United States; 3 Psychology, Vanderbilt University, Nashville, TN, United States; 4 Radiology and Radiological
Sciences, Vanderbilt University, Nashville, TN, United States
We compare single-shot gradient-echo 2D-EPI, multi-shot gradient-echo 3D-FFE and multi-shot gradient-echo 3D-PRESTO in a polar angle retinotopic
mapping experiment at four isotropic resolutions (1.12mm3, 1.67mm3, 2mm3, and 3mm3) at 7 Tesla. Retinotopic maps in agreement with literature were
obtained at all resolutions. The 3D sequences provided similar BOLD sensitivity and significantly less distortion compared to 2D-EPI. In addition, 3D-
PRESTO provided much higher temporal resolution than 2D-EPI. Our findings suggest rich potential for high-resolution 3D imaging sequences in
retinotopic mapping and other functional MRI experiments at high field.
1092. What Is the Optimum FMRI Procedure with Auditory Stimulation?
Karsten Mueller 1 , Toralf Mildner 1 , Tom Fritz 1 , Joeran Lepsien 1 , Christian Schwarzbauer 2 , Harald E.
Möller 1
1 Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany; 2 Aberdeen Biomedical Imaging Centre, University
of Aberdeen, United Kingdom
To present auditory stimuli in the absence of scanner noise, the sparse temporal sampling (STS) approach was introduced. The interleaved-silent steady-state
(ISSS) technique is combining the idea of splitting image acquisition and stimulus presentation with a better sampling of the fMRI signal. We performed an
auditory experiment with pleasant and unpleasant stimuli using four fMRI sessions: STS, ISSS, and simultaneous stimulus presentation and image
acquisition with axial and sagittal scanning. The total acquisition time was the same in all four sessions. The best sensitivity for detecting activations of subcortical
regions (such as the amygdala) was found for ISSS.
1093. Feasibility of BOLD Magnetic Resonance Imaging of Lung Tumors at 3T
Qing Yuan 1 , Yao Ding 1 , Rami R. Hallac 1 , Paul T. Weatherall 1 , Robert Doug Sims 1 , Thomas Boike 2 , Robert
Timmerman 2 , Ralph P. Mason 1
1 Radiology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX, United States; 2 Radiation Oncology, University
of Texas Southwestern Medical Center at Dallas, Dallas, TX, United States
It is expected that BOLD MRI should be sensitive to tumor vascular oxygenation. In lung tumors BOLD MRI is challenging due to potential image artifacts
from motion, blood flow, and susceptibility. The goal of this preliminary study was to optimize the BOLD imaging technique at 3T in patients with untreated