TRADITIONAL POSTER - ismrm

Poster Sessions
1264. Symptomatic Patients with Mild to Moderate Carotid Stenosis: Plaque Features at MRI and
Association with Cardiovascular Risk Factors and Statin Use
Robert Kwee 1 , Robert van Oostenbrugge, Martin Prins, Jos van Engelshoven, Joachim Wildberger, Werner
Mess, Eline Kooi
1 Maastricht University Medical Center, Maastricht, Limburg, Netherlands
We found that TIA/stroke patients with moderate carotid stenosis have a higher prevalence of complicated plaques at MRI compared to TIA/stroke patients
with mild stenosis. Increasing age is positively associated with the presence of IPH, while the use of statins is negatively associated with complicated plaque
features. Other major cardiovascular risk factors were not associated with plaque composition, suggesting that assessment of plaque composition provides
independent information, which might be used to improve risk-stratification for stroke.
1265. Assessment of Inflammation in a Rabbit Model of Early Atherosclerosis: Reproducibility and
Accuracy of Kinetic Analysis Approaches with Black-Blood DCE-MRI
Huijun Chen 1 , Jinhui Shen 1 , William S. Kerwin 1
1 Department of Radiology, University of Washington, Seattle, WA, United States
DCE-MRI has been shown to be sensitive to inflammatory content within plaque. Previous bright-blood technique is not compatible with early lesions due to
the enhancement contamination from lumen. Recently, the area under enhancement curve (AUC) has been found to be associated with neovessels in early
atherosclerosis by black-blood imaging. In this study, we demonstrated the potential for kinetic modeling of black blood DCE-MRI of atherosclerotic plaque
using a reference region approach to the Patlak model. Using an animal model of early atherosclerosis, both kinetic parameters exhibited better
reproducibility and stronger correlation with inflammatory bio-markers than the AUC ratio.
1266. MRI Detects Oxidative Stress Induced by Methaemoglobin
General Leung 1 , Alan R. Moody 1
1 Medical Imaging, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada
Carotid plaque haemorrhage detected by magnetic resonance imaging appears to be prognostic regarding plaque progression and patient outcome. It is
accepted that oxidative modification of low density lipoprotein (LDL) first causes then drives plaque development. We demonstrate in vitro that the signal
hyperintensity caused by ferric haemoglobin, a major portion of intraplaque haemorrhage detected by MRI, is associated with an environment that is a potent
oxidiser of LDL.
1267. Comparison of Black-Blood Magneization Preparation Techniques for 3D Vessel Wall Imaging in the
Lower Extremities
Keigo Kawaji 1,2 , Thanh D. Nguyen 2 , Beatriu Reig 2 , Pascal Spincemaille 2 , Martin R. Prince 2 , Yi Wang 1,2
1 Biomedical Engineering, Cornell University, Ithaca, NY, United States; 2 Radiology, Weill Cornell Medical College, New York, NY,
United States
This work compared the performance of four black-blood magnetization preparation techniques [double inversion recovery (DIR), spatial presaturation of
upstream blood (SpSat), motion-sensitizing magnetization preparation (MSprep), and T2prep inversion recovery (T2prep-IR)] in suppressing blood signal in
a 3D balanced steady-state free precession MRA of the lower extremity. In 11 volunteers, the proximal popliteal was imaged at 1.5-Tesla with the four
magnetization preparation techniques. Both MSprep and T2prep-IR provided global blood suppression and vessel wall visualization across a 3D volume,
while upstream blood nulled by DIR and SpSat did not travel across the entire 3D volume.
1268. Ruptured Carotid Plaques as a Feature in Patients with Unstable Angina Pectoris
Jianming Cai 1 , Qingjun Wang 1 , Yong Wang 1 , Youquan Cai 1 , Lin Ma 1 , Dongxiang Xu 2 , Chun Yuan 2
1 Radiology, Chinese PLA General Hospital, Beijing, China; 2 Radiology, University of Washington, Seattle, WA, United States
By using multi-contrast high-resolution MRI, we studied prospectively whether carotid plaque characteristics can predict unstable angina pectoris (UAP). In
the present study, each subject with stenosis >50% in one or more major coronary arteries was performed a carotid MRI examination on a 3.0-T MRI
scanner. Our findings show that the presence of fibrous cap rupture was the strongest independent predictor of UAP. With a multi-contrast high-resolution
MRI, the ruptured carotid plaques may be a surrogate marker for identifying patients at high risk of UAP and may contribute to a better risk stratification of
patients with coronary artery disease.
1269. Intracranial Vessel Wall Imaging at 7 Tesla
Jaco J.M. Zwanenburg 1 , Anja G. van der Kolk 1 , Jeroen Hendrikse 1 , Peter R. Luijten 1
1 Radiology, University Medical Center Utrecht, Utrecht, Netherlands
A volumetric (3D) turbo spin echo (TSE) sequence for intracranial vessel wall imaging at 7 Tesla is presented. Images show the vessel walls of the circle of
Willis, and of the ophtalmica.
1270. Measurement of the Mean ADC Values of Lipid, Hemorrhage and Overall Wall Components Using In-
Vivo Human Carotid Artery Diffusion Weighted Imaging
Seong-Eun Kim 1,2 , Scott McNally 2 , Laura K. Findeiss 2 , Jordan Hulet 3 , John Roberts 1,2 , Eun-Kee Jeong 1,2 ,
Dennis L. Parker 1,2 , Gerald S. Treiman 4,5
1 UCAIR, University of Utah, Salt Lake City, UT, United States; 2 Department of Radiology, University of Utah, Salt Lake City, UT,
United States; 3 Department of Biomedical Informatics, University of Utah; 4 Department of Surgery, University of Utah, Salt Lake
City, UT, United States; 5 Veterans Affair, VASLCHCS, Salt Lake City, UT, United States
Atherosclerotic plaques are composed of varying degrees of lipid, necrotic tissue, loose connective tissue, hemorrhage, and calcification. The extent of lipid
accumulation and the presence of intramural hemorrhage have been found to be associated with the degree of plaque vulnerability and risk of plaque rupture.