TRADITIONAL POSTER - ismrm

Poster Sessions
2316. Trigeminal Autonomic Cephalalgias Characterized by Similar Structural Differences in the Anterior
Hypothalamus
Enrico Arkink 1 , Nicole Schmitz 1,2 , Guus Schoonman 3 , Jorien van Vliet 3,4 , Gisela Terwindt 3 , Mark van
Buchem 1 , Michel Ferrari 3 , Mark Kruit 1
1 Radiology, Leiden University Medical Center, Leiden, Netherlands; 2 Psychiatry, Amsterdam Medical Center, Amsterdam,
Netherlands; 3 Neurology, Leiden University Medical Center, Leiden, Netherlands; 4 Neurology, Medisch Centrum Haaglanden, Den
Haag, Netherlands
Trigeminal autonomic cephalalgias include cluster headache, paroxysmal hemicrania and SUNCT. An earlier voxel-based morphometry (VBM) study
pointed at the posterior inferior hypothalamus to be involved in CH, but results were never reproduced. In the current study we used state of the art wholebrain
and regional VBM, and manual segmentation of the hypothalamus, in analyzing the brains of 151 subjects with TACs (n=70), migraine patients (n=33)
and controls (n=48). We found the anterior part (but not the posterior part) of the hypothalamus, including the suprachiasmatic nucleus (“the biological
clock”), to be larger in TACs compared to migraineurs and controls. Our results seem to be specific for TACs, and question the validity and/or relevance of
the earlier finding, including its role in deep brain stimulation as treatment for intractable cluster headaches.
2317. Clinically-Driven Fast and High-Resolution Mapping of T1, M0, and B1 with Whole Brain Coverage
Mohammad Sabati 1 , Baranavasi Govindaraju 1 , Andrew Maudsley 1
1 Radiology, University of Miami, Miami, FL, United States
Quantitative MR techniques, such as accurate mapping of the longitudinal relaxation time and water content, have become more important in neurological
research. The current T1 mapping methods are generally lengthy and not adequate in a clinical environment. Also, further acquisitions are usually required
to obtain the brain tissue water content. Several factors, including RF field inhomogeneities and low SNR impair the accuracy of these methods. In this
study, we present a modified two-acquisition SPGR method for simultaneous B1, T1, and M0 mapping with a 1-mm isotropic spatial resolution that covers
the entire human brain in a clinically acceptable time.
2318. Orientation Selectivity of Individual Voxels in Early Visual Areas Using 7 Tesla
Geoffrey Ghose 1,2 , Cheryl Olman, 2,3 , Kamil Ugurbil 2 , Essa Yacoub 2
1 Neuroscience, University of Minnesota, Minneapolis, MN, United States; 2 CMRR, University of Minnesota, Minneapolis, MN,
United States; 3 Psychology, University of Minnesota, Minneapolis, MN, United States
Using 1.5 mm isotropic GE imaging of BOLD activation to a continuously rotating stimulus, we find individual voxels with significant orientation
selectivity in human visual areas V1, V2, and V3.
2319. Layer-Specific MRI of the Rat Retina with Intraocular Injection of Gadolinium-DTPA
Eric Raymond Muir 1,2 , Timothy Q. Duong 2
1 Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA, United States; 2 Research Imaging Institute,
Ophthalmology/Radiology, UT Health Science Center San Antonio, San Antonio, TX, United States
The retina can be divided into seven cellular and synaptic layers. It has been shown that intraocular injection of manganese enhances contrast in the rat
retina, revealing 7 layers with MRI. Gadolinium-DTPA is a T1 shortening contrast agent like manganese, but the localization of the two within in a tissue
could be expected to be to differ, potentially leading to different layer-specific enhancement. In this study we used intraocular injection of gadolinium to
provide unique layer enhancement in the rat retina. Gadolinium-enhanced MRI clearly resolved six retinal layers at 25x25 µm.
2320. Contrast at Ultra-High Field: Relaxation Times in the Rat Brain at 16.4 T
Rolf Pohmann 1
1 Magnetic Resonance Center, Max Planck Institute for Biological Cybernetics, Tübingen, Germany
Knowledge of the relaxation times is not only necessary for sequence optimization; it may also be decisive to judge the advantages for ultra-high field MRI.
Here, T 1 , T 2 and T *
2 in the rat brain were measured at 16.4 T with a spatial resolution of 180 µm inplane. The relaxation times were quantified with high
accuracy for 20 anatomical structures and maps were generated to display the spatial distribution of the relaxation times over the brain.
2321. New Approaches to the Study of Comparative Neuroanatomy in Marine Vertebrates Using MRI: The
Whale Shark, Rhincodon Typus, as a Case Study
Kara E. Yopak 1 , Lawrence R. Frank 1
1 Center for Scientific Computation in Imaging, UCSD, La Jolla, CA, United States
The study of species with unique behavioral and morphological specializations is critical when teasing apart evolutionary trends, yet becomes difficult, as
often these species are extremely rare and invasive methodologies are impractical. This paper examines the use of MRI to obtain high-resolution image data
in an important but damaged brain specimen of the whale shark, Rhincodon typus, wherein digital reconstruction allowed for non-invasive quantification of
its brain organization. We will discuss the effectiveness of MRI as investigative tool for non-invasive visualization and quantification of the internal anatomy
of fishes.
2322. Detection of Amyloid-Beta Plaques Using Phase Imaging at 9.4 Tesla
Wen-Tung Wang 1 , In-Young Choi 1,2 , Jieun Kim 1 , Sang-Pil Lee 1
1 Hoglund Brain Imaging Center, University of Kansas Medical Center, Kansas City, KS, United States; 2 Neurology, Molecular &
Integrative Physiology, University of Kansas Medical Center, Kansas City, KS, United States
Magnetic resonance imaging is the only modality that can provide sufficient spatial resolution and image contrast to visualize Alzheimer’s amyloid plaques
noninvasively. Previously Alzheimer’s amyloid plaques have been visualized in images acquired using spin-echo and gradient echo sequences at 7 T and 9.4
T. At high fields, it has been reported that the increased susceptibility-related contrast resulted in additional anatomical information, such as delineation of