TRADITIONAL POSTER - ismrm

Poster Sessions
2519. MRE of in Vivo Human Lung Parenchyma: Feasibility Study of Motion Encoding Using the Imaging
Gradients with 1 H MRI
Yogesh K. Mariappan 1 , Kevin J. Glaser 1 , Armando Manduca 1 , Richard L. Ehman 1 , Kiaran P. McGee 1
1 Department of Radiology, Mayo Clinic, Rochester, MN, United States
Application of Magnetic Resonance Elastography within the lung is challenging because of the inherently low 1 H MR signal. The additional motionsensitizing
gradients inserted into the conventional MR sequence necessary for MRE results in longer echo times, further degrading the signal from lung
parenchyma. We hypothesized that with appropriate manipulations, the crusher gradients of a spin echo sequence can be used for motion detection, while
maintaining a short echo time. We tested this hypothesis in healthy human volunteers and found that it is feasible to detect motion within the lungs with the
imaging gradients while maintaining sufficient lung tissue signal.
2520. A Novel Method Using Proton MRI and Image Registration to Investigate Relative Regional
Pulmonary Compliance
Alexandra Rose Morgan 1,2 , Geoff J.M. Parker 1,2 , Marietta L.J. Scott 3 , Tim F. Cootes 1,2 , Josephine H.
Naish 1,2
1 Imaging Science and Biomedical Engineering, School of Cancer and Imaging Sciences, The University of Manchester, Manchester,
United Kingdom; 2 The Biomedical Imaging Institute, The University of Manchester, Manchester, United Kingdom; 3 AstraZeneca,
Alderley Park, Macclesfield, United Kingdom
Current diagnosis methods in chronic obstructive pulmonary disease (COPD) are not capable of examining regional pathological changes in mechanical
properties. We have developed a method for investigating relative regional pulmonary compliance using proton magnetic resonance imaging (MRI). A 2D
half-Fourier acquired single-shot turbo spin-echo (HASTE) sequence was optimised for lung imaging. A mesh-based group-wise affine image registration
was applied to images ordered according to respiratory cycle position. Information from the registration allowed relative regional compliance measures to be
extracted and mapped over the lung. Maps show differences between healthy volunteers and COPD patients and can indicate likely regions of disease.
2521. Quantification of Bleomycin Induced Lung Injury by Means of 1 H Magnetic Resonance Elastography
Kiaran P. McGee 1 , Richard L. Ehman 1 , Rolf D. Hubmayr 2 , David L. Levin 1 , Mary Breen 3 , Debora
Rasmussen 2 , Yogesh K. Mariappan 1
1 Radiology, Mayo Clinic and Foundation, Rochester, MN, United States; 2 Pulmonology & Critical Care, Mayo Clinic and Foundation,
Rochester, MN, United States; 3 College of Arts and Sciences, Boston College, Boston, MA, United States
Interstitial lung disease (ILD) induced end stage fibrosis is a multi phase process that includes presence of an exudate followed by either edema clearance or
organization of the space filling material and fibrosis. We have applied magnetic resonance elastography (MRE) to determine if this method can differentiate
between normal and those processes associated with ILD. MRE estimates of shear modulus increased following lung injury when compared to an air-filled
lung suggesting that lung injury-induced restructuring of lung parenchyma results in changes to the intrinsic mechanical properties of the lung and that these
changes can be quantitated with MRE.
2522. Free-Breath DCE MRI for Solitary Pulmonary Nodule with Motion Correction Based on Non-Rigid
Image Registration
Junichi Tokuda 1 , Hatsuho Mamata 1 , Ritu R. Gill 1 , Samuel Patz 1 , Nobuhiko Hata 1 , Robert E. Lenkinski 2 ,
David J. Sugarbaker 3 , Hiroto Hatabu 1
1 Department of Radiology, Brigham and Women's Hospital, Boston, MA, United States; 2 Department of Radiology, Beth Israel
Deaconess Medical Center, Boston, MA, United States; 3 Department of Surgery, Brigham and Women's Hospital, Boston, MA,
United States
We demonstrate perfusion analysis of solitary pulmonary nodule based on free-breath DCE MRI. In DCE MRI studies, the kinetics of signal variation at
lesions following the administration of the contrast agent is analyzed from time-intensity curve. Thus, it is crucial to measure the signal intensity at the
corresponding regions in each frame in the time-series of images for accurate signal intensity curve analysis. However, the respiratory motion of the subjects
during scans causes misalignment of anatomical regions among the frames resulting inaccuracy of time-intensity curve. In this paper, we compare perfusion
analyses based on motion-compensated MRI data and manual measurement.
2523. Non-Contrast-Enhanced Pulmonary MR Imaging: Comparison of Capability for Nodule Screening
Between 1.5T and 3.0T MR Systems
Keiko Matsumoto 1 , Yoshiharu Ohno 1 , Hisanobu Koyama 1 , Munenobu Nogami 1 , Daisuke Takenaka 1 ,
Yumiko Onishi 1 , Nobulazu Aoyama 2 , Hideaki Kawamitsu 2 , Tsutomu Araki 3 , Kazuro Sugimura 1
1 Department of Radiology, Kobe University Graduate School of Medicine, Kobe, Hyogo, Japan; 2 Division of Radiology, Kobe
University Hospital, Kobe, Hyogo, Japan; 3 Department of Radiology, University of Yamanashi, Japan
Academic and social interest to radiation induced cancer development on CT examination is increasing in the world. Since 1997, several investigators have
suggested that pulmonary MR imaging on 1.5T MR system has potential for nodule detection as substitution to CT. To the best of our knowledge, no one
directly compare the capability of non-contrast-enhanced (non-CE) pulmonary MRI for pulmonary nodule detection between 1.5T and 3.0T MR systems.
The purpose of this study was to prospectively and directly compare the capability of non-CE pulmonary MR imaging on 3.0T MR system for nodule
detection than that on 1.5T MR system.