TRADITIONAL POSTER - ismrm

Poster Sessions
2310. Detection of Cortical Layers Via Magnetization Transfer Imaging at 7T
Olivier E. Mougin 1 , Alain Pitiot 2 , Penny A. Gowland 1
1 Sir Peter Mansfield Magnetic Resonance Centre, School of Physics & Astronomy,University of Nottingham, Nottingham,
Nottinghamshire, United Kingdom; 2 School of Psychology, Institute of Neuroscience, Nottingham, Nottinghamshire, United Kingdom
Variations in magnetization transfer (MT) ratio across the cortex have been detected using high resolution MT scans at 7T and are assumed to correspond to
variations in myelination, and variations in MT corresponding to the stria of Gennari have been detected on MT maps.
2311. Improved Direct Localization of the Human Pedunculopontine Nucleus (PPN) by 3D FLASH MRI at
Sub-Millimeter Resolution
Tobias M. Lindig 1,2 , Sorin Breit 1 , Ludger Schöls 1 , Thomas Nägele, Uwe Klose 2 , Gunther Helms 3
1 Department of Neurology and Hertie-Institute for Clinical Brain Research, University Hospital Tuebingen, Tuebingen, Germany;
2 Section of experimental MR of the CNS, Department of Diagnostic and Interventional Neuroradiology, University Hospital
Tuebingen, Tuebingen, Germany; 3 MR-Research in Neurology and Psychiatry, University Medical Center Goettingen, Goettingen,
Germany
The pedunculopontine nucleus (PPN) is a potential target for deep brain stimulation to address symptoms of gait freezing and postural instability in
Parkinson’s disease. Proton density-weighted (PD-w) MRI has been recommended to locate its position. Contrast and delineation of the PPN area in healthy
subjects were improved by multi-echo 3D MRI at an increased resolution of 0.8 mm^3, and by using signal amplitude maps S0. These were calculated from
a dual-angle FLASH protocol, thus eliminating the residual influence of T1 from the PD-w images. Usefulness for stereotactic planning was verified on two
patients at 3T using a protocol of 4x4minutes.
2312. Ammon’s Horn Sclerosis Detected in Temporal Lobe Epilepsy with 7 T MRI
Thomas R. Henry 1 , Marie Chupin 2 , Stéphane Lehéricy 3 , Kamil Ugurbil 4 , Frederick Ott 5 , Zhiyi Sha 1 , Pierre-
Francois Van de Moortele 5
1 Neurology, University of Minnesota, Minneapolis, MN, United States; 2 Universite Pierre et Marie Curie-Paris, Paris, France;
3 Neuroradiology, Universite Pierre et Marie Curie-Paris, Paris, France; 4 Center for Magnetic Resonance Research, University of
Minnesota, Minneapolis, MN, United States; 5 Radiology, University of Minnesota, Minneapolis, MN, United States
Increased contrast and spatial resolution at 7 T permitted the reliable detection of internal architecture of the hippocampal formation. Submillimetric T2w
images at 7 T consistently resolved the continuous white matter band, which separates deep portions of CA1-3 from CA4 and the dentate hilus. The
resulting accuracy permitted intrahippocampal (subregional) volumetry. These preliminary results strongly support expectations that brain imaging at very
high magnetic field may allow for a more accurate patient classification based on qualitative and quantitative information that is difficult or impossible to
collect reliably at lower field.
2313. In Vivo Imaging of Human Hippocampal Subfields at 7 Tesla
Caitlin Judith Hardy 1 , Vasthie Prudent, Songtao Liu, Graham Wiggins, Dolores Malaspina 2 , Oded Gonen
1 Radiology, NYU School of Medicine, New York, NY, United States; 2 Psychiatry, NYU School of Medicine
Using a combination of 7 T field, B0-shim, high count receive-coil arrays and heavy T2* weighting we were able to depict hippocampal subfields down to
100 micron in 10/10 young adults in a clinically acceptable time of 14 minutes.
2314. Delineation of Human Primary Auditory Cortex on the Basis of a Combined T1 and T2 Weighted MR
Contrast
Christian Wasserthal 1 , Karin Engel 2 , Jörg Stadler 1 , Bruce Fishl 3,4 , Patricia Morosan 5 , Andre Brechmann 1
1 Special-Lab Non-Invasive Brain Imaging, Leibniz-Institute for Neurobiology, Magdeburg, Germany; 2 Department of Simulation and
Graphics, Otto-von-Guericke University of Magdeburg, Germany; 3 Department of Radiology, Harvard Medical School, Charlestown,
MA, United States; 4 Computer Science and AI Lab, Massachusetts Institute of Technology, Cambridge, MA, United States; 5 Institute
of Medicine, Research Center Jülich, Germany
In the visual system the primary cortex area can robustly be identified by retinotopic mapping. In the auditory modality, a routine method to delineate the
primary auditory cortex (PAC) area in individual human subjects is not available.
We developed a method to anatomically identify the PAC area on the basis of myelin content in single subjects by creating an artificial contrast using
conventional T1 and T2 weighted imaging at 3 Tesla. Results show a region on the medial two thirds of Heschl’s gyrus that is very consistent to the
probability map of the PAC defined in post-mortem brains.
2315. Differences in the Proportional Volume of Different Brain Regions Relative to the Whole Brain Size
Marcus Belke 1 , David H. Salat 2 , Enno Wehrmann 1 , Katja Menzler 1 , Ulrike Lengler 3 , Wolfgang H. Oertel 1 ,
Felix Rosenow 1 , Karsten Krakow 3 , Susanne Knake 1
1 Department of Neurology, Philipps-University Marburg, Marburg, Germany; 2 Athinoula A. Martinos Center for Biomedical Imaging,
Harvard Medical School, Boston, MA, United States; 3 Brain Imaging Center Frankfurt, University of Frankfurt, Frankfurt, Germany
We investigated association between total intracranial volume (TIV) and the volume of several cortical, subcortical and white matter regions. After an
automated parcellation of the brain, a slope was calculated, representing the proportional volume of each structure relative to the TIV. Cortical regions were
particularly associated with TIV. The greatest slope of the subcortical regions was found for the brainstem. In a second test gender differences were
investigated. Large differences were found between men and women when uncorrected volumes were compared. After correction for the influence of the
TIV, no gender differences were found in any of the investigated regions.