TRADITIONAL POSTER - ismrm

Poster Sessions
2672. MR Imaging in the Evaluation of (Deep) Infiltrating Endometriosis: The Value of Diffusion-Weighted
Imaging
Milou Patricia Helene Busard 1 , Velja Mijatovic 2 , Cees van Kuijk, Indra Pieters-van den Bos, Peter
Hompes, Jan Hein van Waesberghe
1 Radiology, VUMC, Amsterdam, Noord Holland, Netherlands; 2 Gynecology, VUMC, Amsterdam, Noord Holland, Netherlands
To assess the value of magnetic resonance (MR) diffusion-weighted imaging (DWI) in deep infiltrating endometriosis (DIE), DWI was added to the standard
MR imaging protocol. Apparent diffusion coefficient (ADC) values were calculated using b-values of 50, 400, 800 and 1200 s/mm2. In 60 lesions, mean
ADC values of DIE retrocervical (0.70 x 10-3/mm2 /s), infiltrating the colon (0.79 x 10-3/mm2/s) and bladder (0.76 x 10-3/mm2/s) were consistently low
and did not significant differ between pelvic locations (p=0.63). In addition, ADC values show comparable diagnostic performance in differentiating
endometrial cysts from other pelvic cysts as evaluation of T2- and T1-weighted images.
2673. ASL, BOLD, and Phase Contrast MRI Measurements in the Kidneys of Normotensive and
Hypotensive Swine.
David Joseph Niles 1 , Andrew L. Wentland 1,2 , Nathan S. Artz 1 , Thomas M. Grist 1,2 , Sean B. Fain 1,2 , Aji
Djamali 3 , Elizabeth A. Sadowski 2
1 Medical Physics, University of Wisconsin School of Medicine & Public Health, Madison, WI, United States; 2 Radiology, University
of Wisconsin School of Medicine & Public Health, Madison, WI, United States; 3 Nephrology, University of Wisconsin School of
Medicine & Public Health, Madison, WI, United States
Functional MR imaging techniques provide a non-invasive method for studying renal physiology. This study measured blood flow in the main renal artery
using phase contrast MR, cortical and medullary perfusion using ASL and oxygenation using BOLD MR imaging sequences, in normotensive and
hypotensive swine. Our results demonstrate medullary oxygenation is maintained despite a decrease in renal artery blood flow and regional tissue perfusion
in the hypotensive states. This has been previously demonstrated by others with invasive probes in animals. Our functional renal MR techniques may be
applied to future studies in humans to study blood flow and oxygenation simultaneously.
2674. Diffusion-Weighted and Blood Oxygen Level-Dependent MRI in Renal Tubulointerstitial
Nephropathy£ºInitial Experience
Xuedong Yang 1 , Ju Cao 2 , Xiaoying Wang 1
1 Department of Radiology, Peking University First Hospital, Beijing, China; 2 Nephrology Department, Peking University First
Hospital, Beijing, China
DW and BOLD MRI can reflect changes of water diffusion and oxygen level in TIN kidney. Both methods can be used to study the TIN patients. Combined
use of the two methods may aid in differentiating ATIN, CTIN from normal kidney. Medullary R2* significantly correlates with eGFR in TIN patients.
2675. Measurements of Renal Perfusion, Oxygenation, and Total Renal Blood Flow in Swine
Andrew L. Wentland 1,2 , Nathan S. Artz 1 , Arjang Djamali 3 , Thomas M. Grist 1,2 , Sean B. Fain 1 , Elizabeth A.
Sadowski 2
1 Medical Physics, University of Wisconsin School of Medicine & Public Health, Madison, WI, United States; 2 Radiology, University
of Wisconsin School of Medicine & Public Health, Madison, WI, United States; 3 Nephrology, University of Wisconsin School of
Medicine & Public Health, Madison, WI, United States
Given the recent link between nephrogenic systemic fibrosis and gadolinium-based contrast agents (GBCAs), it has become increasingly important to
evaluate techniques that operate independently of GBCAs. In this study, measurements of perfusion, oxygenation, and total renal blood flow (TRBF) were
acquired in swine with arterial spin labeling-based perfusion, BOLD MRI, and phase contrast MRI, respectively. Scans were repeated during a state of
increased blood flow with acetylcholine and also a state of decreased blood flow with the anesthetic isoflurane over a two-hour period. Measurements
successfully demonstrated increased perfusion, oxygenation, and TRBF with acetylcholine, and the opposite trend with isoflurane.
2676. Renal-ASL Using a Multiple-Inversion Time, Free Breathing, STAR-HASTE Technique at 3T
Mark Stephen Dobbs 1,2 , Neil Woodhouse 3 , Geoff J.M Parker 1,2 , Josephine H. Naish 1,2
1 Imaging Science and Biomedical Engineering, The University of Manchester, Manchester, Greater Manchester, United Kingdom;
2 The University of Manchester Biomedical Imaging Institute, Manchester, Greater Manchester, United Kingdom; 3 AstraZeneca,
Manchester, Greater Manchester, United Kingdom
ASL has been applied extensively in the brain, but there has been increasing interest in applying ASL to the kidneys, particularly as a result of concerns over
the link between contrast agents and NSF. Currently, most human renal-ASL has been performed using a single inversion time, and applying a simple model
for quantification. In this abstract we aim to demonstrate the feasibility of applying the Buxton model, at 3T, using a STAR based labelling technique and a
free breathing approach. Here, we demonstrate the practicality of fitting for arrival time, producing high quality parametric output.
2677. Non-Invasive Investigation of Diabetic Kidney Disease by Magnetic Resonance Imaging
Peter Edward Thelwall 1 , Roy Taylor 1 , Sally M. Marshall 2
1 Newcastle Magnetic Resonance Centre, Newcastle University, Newcastle upon Tyne, United Kingdom; 2 Institute of Cellular
Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom
We have applied MR imaging methods to diabetic kidney disease by investigating the differences in kidney structure, blood flow and oxygenation between
volunteers with Type 1 diabetes with and without diabetic nephropathy, and in non-diabetic control subjects. We hypothesised that early changes in kidney
structure and function caused by diabetic nephropathy could be identified by altered renal structure, blood flow, and changes in oxygenation on water
loading. Differences in renal artery flux were observed between volunteer groups.