TRADITIONAL POSTER - ismrm

Poster Sessions
1298. Cardiac Free-Breathing Balanced SSFP Cine Sequences: Radial Vs. Cartesian K-Space Reconstruction
Lorenzo Mannelli 1 , Monvadi Barbara Srichai-Parsia 2 , Daniel Kim 1 , Xhafer Sinani 2 , Rajesh Hiralal 1 , Ruth
P. Lim 1
1 Radiology, New York University, New Nork, United States; 2 Radiology, Bellevue Hospital Center, New York, United States
In this study we compare free-breathing balanced SSFP cine sequences (radial vs. Cartesian K space reconstruction) in a short series of consecutive patients.
Radial acquisitions have the potentiality to be one of the possible strategies in patients who are unable to breath-hold or who have significant arrhythmias
where segmented SSFP cine imaging is challenging and suboptimal for left and right ventricle function assessment.
1299. MR Imaging of Cardiac Wall-Motion at 1.5T and 7T: SNR and CNR Comparison
Stefan Maderwald 1,2 , Kai Nassenstein, 12 , Stephan Orzada 1,2 , Lena C. Schäfer 1,2 , Mark Oehmigen 1 , Andreas
K. Bitz 1,2 , Oliver Kraff 1,2 , Irina Brote 1,2 , Susanne C. Ladd 1,2 , Mark E. Ladd 1,2 , Harald H. Quick 1,3
1 Erwin L. Hahn Institute for Magnetic Resonance Imaging, Essen, Germany; 2 Department of Diagnostic and Interventional Radiology
and Neuroradiology, University Hospital Essen, Essen, Germany; 3 Institute of Medical Physics, Friedrich-Alexander-University
Erlangen-Nürnberg, Erlangen, Germany
Increased SNR and enhanced soft tissue contrasts are anticipated for 7T high-field MRI in comparison to 1.5T. The expected increases in SNR and CNR are
of particular interest for high-resolution cardiac MR applications in humans. After addressing some of the 7T related transmit/receive problems, five healthy
volunteers were imaged at 1.5T and 7T to measure and to compare SNR and CNR of cardiac function sequences along the short axis. It can be concluded
that with the demonstrated increases in SNR and CNR, 7T cardiac function MRI with spoiled gradient echo at 7T outperforms cardiac function MRI with
SSFP at 1.5T.
1300. Toward 7 Tesla Cardiac MRI for Clinical Application
Stefan Maderwald 1,2 , Stephan Orzada 1,2 , Lena C. Schäfer 1,2 , Andreas K. Bitz 1,2 , Kai Nassenstein, 12 , Oliver
Kraff 1,2 , Irina Brote 1,2 , Mark Oehmingen 1 , Susanne C. Ladd 1,2 , Mark E. Ladd 1,2 , Harald H. Quick 1,3
1 Erwin L. Hahn Institute for Magnetic Resonance Imaging, Essen, Germany; 2 Department of Diagnostic and Interventional Radiology
and Neuroradiology, University Hospital Essen, Essen, Germany; 3 Institute of Medical Physics, Friedrich-Alexander-University
Erlangen-Nürnberg, Erlangen, Germany
Highfield MRI at 7T inherently offers higher signal-to-noise and enhanced soft tissue contrasts when compared to 1.5T or even 3T MRI, which might
improve image quality in selected imaging applications like high-resolution cardiac MRI in humans. To push cardiac MRI at 7T another step further, a
number of artifacts and imaging constraints related to 7T transmit/receive problems have to be addressed first. Additionally, protocols already established for
1.5T and 3T cardiac imaging have to be evaluated. This study presents two RF coil concepts to tackle some transmit/receive issues and evaluates established
cardiac protocols which have been modified for application at 7T.
1301. NMR Molecular Profiling of Human Blood Plasma in Induced Myocardial Ischemia
Jose Manuel Morales 1 , Fabian Chaustre 2 , David Moratal 3 , Vicent Bodi 4 , Daniel Monleon 2
1 Universitat de Valencia, Valencia, Spain; 2 Fundacion Investigacion Hospital Clinico Valencia, Valencia, Spain; 3 Center for
Biomaterials and Tissue Engineering, Universitat Politecnica Valencia, Valencia, Spain; 4 Hospital Clinico Universitario de Valencia,
Valencia, Spain
The protocols of management of patients entering emergency rooms because thoracic pain of potential ischemic origin without necrosis include serial
measurement s of biomarkers, stress tests and, in many cases, unnecessary hospitalization. In this context, detection of metabolic markers, which represent
dynamic changes in just a few minutes after ischemia, is an attractive option both for diagnosis precision and for rapid and efficient management. In this
communication, we used NMR metabolic profiling to characterize metabolically blood plasma of patients pre and post angioplasty. Statistical multivariate
analysis showed differences in signals belonging mainly to ketonic bodies and fatty acids.
Myocardial Viability - Experimental Models
Hall B Thursday 13:30-15:30
1302. Combined Manganese-Enhanced MRI and DTI Methods to Assess Post-Myocardial Infarction
Molecular and Structural Remodeling
Benjamin Waghorn 1,2 , Wen Li 3,4 , Xin Yu 3,4 , Tom C.-C. Hu 1,2
1 Department of Radiology, Medical College of Georgia, Augusta, GA, United States; 2 Nuclear and Radiological Engineering and
Medical Physics Programs, Georgia Institute of Technology, Atlanta, GA, United States; 3 Department of Biomedical Engineering,
Case Western Reserve University, Cleveland, OH, United States; 4 Case Center for Imaging Research, Case Western Reserve
University, Cleveland, OH, United States
Intracellular calcium overloading and structural changes are known to occur in the post-myocardial infarction (MI) heart. This study demonstrates the use of
combined cardiac T 1 -mapping manganese-enhanced MRI and DTI in a mouse MI model to examine the relationship between indirect Ca 2+ handling and
structural modification during the myocardial remodeling process. Decreased Mn 2+ uptake was observed for the infracted tissue, as well as the ischemic periinfarct
tissue, with a decrease in diffusivity and an increase in diffusion anisotropy also observed in the infarct hearts. Results from this study could provide a
method for monitoring the salvageability of the peri-infarcted zone.