TRADITIONAL POSTER - ismrm

Poster Sessions
Hepato-Biliary & Liver
Hall B Monday 14:00-16:00
2581. Fat Content Quantification Errors Using Multiple Gradient Echo Imaging: A Phantom and Simulation
Study
Benjamin Leporq 1 , Hélène Ratiney 1 , Sophie Cavassila 1 , Frank Pilleul 2 , Olivier Beuf 1
1 Université de Lyon, Creatis-LRMN, CNRS UMR 5220, Inserm U630, INSA-Lyon, Université Lyon 1, Villeurbanne, France;
2 Université de Lyon, Creatis-LRMN, CNRS UMR 5220, Inserm U630, INSA-Lyon, Université Lyon 1, Hospices Civils de Lyon,
Lyon, France
In the past decade, the incidence increase of obesity, diabetes and lipid metabolism disorders involved an epidemic increase of Non-Alcoholic Fatty Liver
Diseases (NAFLD) in the occidental population. Because NAFLD can evolve into Non-Alcoholic Steato-Hepatitis (NASH) and may lead to liver fibrosis up
to cirrhosis, a clinical follow-up of NAFLD would be very valuable. This work investigated fat content quantification error using different models based on
multiple gradient echo imaging and presents some computer simulations, phantom study and examples of in-vivo application. Multiple gradient echo
acquisitions with two different flip angles associated with a model correcting for T1 saturation and T2* decay appears to be a simple but effective noninvasive
method available on all clinical systems to monitor patients with chronic liver diseases.
2582. Improvements in Hepatic Stiffness Assessment with 3-D/3-Axis MR Elastography
Meng Yin 1 , Kevin J. Glaser 1 , Jun Chen 1 , Jayant A. Talwalkar 2 , Armando Manduca 1 , Richard L. Ehman 1
1 Department of Radiology, Mayo Clinic, Rochester, MN, United States; 2 Division of Gastroenterology, Mayo Clinic, Rochester, MN,
United States
One advantage of liver MR elastography (MRE) over biopsy or ultrasound-based transient elastography is its ability to reduce sampling errors by measuring
liver stiffness over a large portion of the liver. While existing 2-D or localized approaches yield valid results in a substantial part of the volume, a full 3-D/3-
axis wave analysis is required for valid measurements of stiffness throughout the entire liver. This investigation compares a 2-D and a 3-D approach for liver
MRE and demonstrates that 3-D MRE analysis improves the homogeneity of hepatic stiffness estimates.
2583. A Software Tool for Volume Registration and Atlas-Based Segmentation of Human Fat-Water MRI
Data in Longitudinal Studies
Anand Arvind Joshi 1 , H Harry Hu 2 , Michael Goran 3 , Richard Leahy 2 , Arthur Toga 1 , Krishna Nayak 2
1 Department of Neurology, David Geffen School of Medicine, UCLA, Los Angeles, CA, United States; 2 Ming Hsieh Department of
Electrical Engineering, University of Southern California, Los Angeles; 3 Keck School of Medicine, University of Southern California,
Los Angeles, CA
Obesity continues to be a worldwide epidemic. Accurate quantification of subcutaneous and visceral adipose tissue depot volumes and the degree fat
infiltration in the liver, the pancreas, skeletal muscle, and the kidneys, are important endpoints in determining the efficacy of therapeutic and interventional
measures against obesity. For example, in longitudinal studies, measures are taken at multiple time points in each subject to determine the effects of diet,
exercise, lifestyle modifications, and surgery, on fat quantity and distribution. In this work, we present an automated atlas-based tool for performing 3D
volume registration and segmentation of abdominal adipose tissue depots and organs.
2584. Orthotopic Liver Transplantation: MRI Based Measurement of Donor Graft Steatosis, Graft
Performance and Outcome.
David John Lomas 1 , Richard T. Black 1 , Andrew J. Patterson 1 , Kieren G. Hollingsworth 1 , Susan Davies 2 ,
Graeme J. Alexander 3 , Mike E. Allison 3 , Neville V. Jamieson 4 , Alex E. Gimson 3 , Raaj K. Praseedom 4 , Chris
J. Watson 4
1 Radiology, University of Cambridge & Addenbrooke's Hospital, Cambridge, Cambridgeshire, United Kingdom; 2 Pathology,
University of Cambridge & Addenbrooke's Hospital, Cambridge, Cambridgeshire, United Kingdom; 3 Hepatology, University of
Cambridge & Addenbrooke's Hospital, Cambridge, Cambridgeshire, United Kingdom; 4 Surgery, University of Cambridge &
Addenbrooke's Hospital, Cambridge, Cambridgeshire, United Kingdom
The results of rapid MRI based measurement of donor graft steatosis immediately prior to orthotopic liver transplantation in 49 patients were correlated with
surgical and histopathology estimates, first week graft performance and 3 and 12 month outcomes. MR measurements correlated significantly with the other
steatosis estimates but did not correlate with early serum performance markers. Both MRI and pathology estimates indicated significantly increased graft
steatosis in those grafts failing at 3 months but not at 12 months. Such MRI based measurements may be a valuable tool for further investigating the impact
of graft steatosis on transplant outcomes.
2585. Effect of Intravenous Gadolinium on Estimation of Liver Stiffness with MR Elastography
Sudhakar Kundapur Venkatesh 1 , Lynette Li San Teo 1 , Bertrand Wei Leng Ang 1 , Richard L. Ehman 2
1 Diagnostic Imaging, National University Health System, Singapore, Singapore; 2 Radiology, Mayo Clinic, Rochester, MN, United
States
MR Elastography is currently the most accurate non-invasive technique for assessment of liver fibrosis. In this study, we investigated whether administration
of gadolinium for routine MRI studies affects the stiffness values estimated. Our study results show that intravenous gadolinium does not affect stiffness
values estimation and diagnostic performance of MRE for detection of liver fibrosis.