Poster Sessions 2004. Magnetization Transfer and Spin-Lattice Relaxation Time Measurements of White Matter Lesions in Normal Aging Mark E. Bastin 1 , Maria Valdés Hernandez 2 , Susana Muñoz Maniega 2 , Catherine Murray 3 , Alan J. Gow 3 , Paul A. Armitage 2 , Joanna M. Wardlaw 2 , Ian J. Deary 3 1 Medical Physics, University of Edinburgh, Edinburgh, United Kingdom; 2 Clinical Neurosciences, University of Edinburgh, Edinburgh, United Kingdom; 3 Psychology, University of Edinburgh, Edinburgh, United Kingdom White matter lesions are a common finding on T2- and FLAIR-weighted MRI scans of older subjects, but their etiology and relationship to cognitive function remains unclear. The aim of this pilot study was to characterize differences in magnetization transfer ratio and spin-lattice relaxation time between macroscopically normal-appearing white matter and white matter lesions in a subset of a unique cohort of aging subjects, the Lothian Birth Cohort 1936. 2005. Hypertension, Arterial Health and Neuronal Integrity in Midlife Andreana P. Haley 1,2 , Tarumi Takashi 3 , Jun Sugawara 3 , Hirofumi Tanaka 3 1 Psychology, The University of Texas at Austin, Austin, TX, United States; 2 UT Imaging Research Center, Austin, TX, United States; 3 Kinesiology, The University of Texas at Austin, Austin, TX, United States The present study bridges the gap between midlife hypertension and late-life cognitive impairment, a relationship that has long been documented but remains poorly understood. We demonstrate that midlife hypertension and associated arterial thickening relate to cerebral measures of neuronal health and viability in middle-aged adults with intact cognitive performance. 2006. Comparison of Brain Metabolites Changes Associated with Visual Sexual Arousal in Premenopausal and Menopausal Women: Functional MR Spectroscopy Tae-Hoon Kim 1 , Gwang-Woo Jeong 1,2 , Han-Su Baek 1 , Gwang-Won Kim 1 , Heoung-Keun Kang 2 , Jong-Chul Yang 3 , Kwangsung Park 4 1 Interdisplinary Program of Biomedical Engineering, Chonnam National University Medical School, Gwangju, Korea, Republic of; 2 Radiology, Chonnam National University Medical School, Gwangju, Korea, Republic of; 3 Psychiatry, Chonbuk National University Hospital, Chonbuk, Korea, Republic of; 4 Urology, Chonnam National University Medical School, Gwangju, Korea, Republic of With menopause, women underwent changes of overall hormones, leading to functional changes of organs. A majority of menopausal women experience some exchanges in sexual function. Using fMRI technique, menopausal a few papers concerning differential brain activation patterns between premenopausal and menopausal women were published. However, it is unclear how brain metabolite change in menopause affects sexual arousal. The purpose of this study was to investigate the brain metabolic changes associated with visual sexual arousal in premenopausal and menopausal women using functional MR spectroscopy (fMRS). 2007. Motion Detection in Healthy Young, Middle-Aged, and Elderly Adults Using a Water Signal Based Navigator Echo: A 1 H MRS Study Sarah Andrea Wijtenburg 1 , Kathleen L. Fuchs 2 , Virginia I. Simnad 3 , Jack Knight-Scott 1 1 Radiology, Children's Healthcare of Atlanta, Atlanta, GA, United States; 2 Neurology, University of Virginia, Charlottesville, VA, United States; 3 Neurology, Evergreen Hospital Medical Center, Kirkland, WA, United States Here, we build upon our earlier work incorporating a CHESS pulse into a STEAM sequence by presenting a new method for analyzing and interpreting motion data collected from three age groups: healthy young (HY), healthy middle-aged (HM), and healthy elderly (HE). Our results show that listed in increasing order of motion during a 1 H MRS STEAM spectroscopy examination: HY, HM, and HE. 2008. Cross-Site Reproducibility of 1 H-MRS Irene Margaret Vavasour 1 , Cornelia Laule 1 , Burkhard Maedler 2 , Trudy Harris 1 , David K.B. Li 1 , Anthony L. Traboulsee 3 , Alex L. MacKay 1 1 Radiology, University of British Columbia, Vancouver, BC, Canada; 2 Physics and Astronomy, University of British Columbia; 3 Medicine, Univeristy of British Columbia Quantitative assessment of 1 H-MRS metabolite concentrations has the potential to be an in-vivo marker for disease progression and treatment efficacy in pharmaceutical trials. The present study examines cross-site reproducibility of 1 H-MRS metabolite concentrations measured on the same 5 people at 6 sites. Average percent differences of inter and intra-site reproducibility was
Poster Sessions 2010. Correlation Between Venous Blood T1 and BOLD FMRI in Young and Elderly Subjects Lirong Yan 1 , Yan Zhuo 1 , Bo Wang 1 , Cheng Li 2 , Jiongjiong Wang 2 1 Institute of Biophysics, Chinese Academy of Sciences, Beijing, China; 2 Department of Radiology, University of Pennsylvania, Philadelphia, PA, United States We investigated the relationship between in vivo measurement of venous blood T1 and BOLD signal changes during visual stimulation in two groups of young and elderly subjects. There was a significant negative correlation between venous blood T1 and BOLD activation across subjects. Upon including venous blood T1 as a covariate, the differences in BOLD activation between the two age groups weakened, suggesting that aging effects on BOLD fMRI may be partly attributed to baseline hematocrit variations. 2011. Increased Resting State Connectivity Between Left and Right Hemispheres with Increasing Age Daniel Joshua Cox 1,2 , Rafat S. Mohtasib 3 , Daniela Montaldi 4 , Laura M. Parkes 1,2 1 Imaging Sciences and Biomedical Engineering, School of Cancer and Imaging Sciences, The University of Manchester, Manchester, Lancashire, United Kingdom; 2 Biomedical Imaging Institute (BII), The University of Manchester, Manchester, Lancashire, United Kingdom; 3 Magnetic Resonance and Image Analysis Research Centre (MARIARC), University of Liverpool, United Kingdom; 4 School of Psychological Sciences, The University of Manchester, Manchester, Lancashire, United Kingdom This study aims to investigate changes in resting state functional connectivity with increasing age. 40 healthy subjects (aged 20 – 76) participated. Gradient echo EPI images were collected during a Stroop task and active regions were found across the group. The BOLD amplitude in the right middle frontal gyrus (MFG) increased with age, reducing laterality of activation. Partial correlation was used to investigate functional connectivity between bilateral MFG, which was found to increase with age between bilateral MFG in adults aged 40yrs+. Increased connectivity was also associated with improved accuracy, suggesting alterations in functional connectivity may be important for performance. 2012. Age-Related Effects on Resting State Default, Executive and Salience Networks Reveal Different Pruning Mechanisms – a Resting State FMRI Study. Vesa Kiviniemi 1 , Harri Littow 1 , Ahmed Abou-elseoud 1 , Katariina Mankinen 2 , Jukka Rahko 3 , Jukka Remes 1 , Juha Nikkinen 1 , Tuomo Starck 1 , Juha Veijola 4 , Christian Beckmann 5 , Osmo Tervonen 1 1 Diagnostic Radiology, Oulu University Hospital, Oulu, Finland; 2 Pediatric department, Oulu University Hospital, Oulu, Finland; 3 Child Psychiatry, Oulu University Hospital, Oulu, Finland; 4 Psychiatry, Oulu University, Oulu, Finland; 5 Clinical Neuroscience, Imperial College, London, United Kingdom Resting state networks undergo various age related changes both in strength and spatial distribution. Some occur in adolescence while many changes also occur later in adulthood. A salience network splits without much strength in any age group. These different findings reflect multiple normal ageing processes of the central nervous system. 2013. Age-Related Differences of Brain Activation Patterns Upon Imaginary Walking Ekkehard Küstermann 1,2 , Markus Ebke 3 , Katja Dolge 4 , Natascha Lohr 1 , Dieter Leibfritz 2 , Manfred Herrmann 1 1 ZKW/Neuropsychologie, Universität Bremen, Bremen, Germany; 2 Organische Chemie, Universität Bremen, Bremen, Germany; 3 Neurologie, Klinikum Bremen-Mitte, Bremen, Germany; 4 JCLLaID, Jacobs University Bremen, Bremen, Germany The steadiness of walking decreases in elderly with advancing age. This study was designed to explore changes in the activation pattern during walking. Healthy young and elderly subjects performed imaginated walking tasks while being scanned. Elderly subjects exhibited stronger and larger activations as compared to younger subjects with a marked increase in the IPL. During imaginated walking, negative BOLD signal changes were only observed in younger, but not in elderly subjects. 2014. Naming Errors and Gray Matter Structural Variations Katie McMahon 1 , Anna Holmes 2 , Shiree Heath 2 , Anthony Angwin 3 , Lindsey Nickels 4 , Eril McKinnon 2 , Sophie Van Hees 2 , David Copland 2,3 1 Centre for Magnetic Resonance, University of Queensland, Brisbane, Queensland, Australia; 2 UQ Centre for Clinical Research, University of Queensland, Australia; 3 School of Health and Rehabilitation Sciences, University of Queensland, Australia; 4 Macquarie Centre for Cognitive Science (MACCS), Macquarie University, Sydney, NSW, Australia The frequency of naming errors increases in normal aging. In this study we examined an elderly cohort of subjects; classified their naming difficulties and correlated this with high resolution structural MRI images. Different regions were structurally correlated for reduced semantic, phonological and visual perception errors, including the inferior temporal lobe, middle temporal lobe, and occipital-parietal regions. 2015. Correlations Between Semantic Priming, Word Recognition and Gray Matter Density Katie McMahon 1 , Anthony Angwin 2 , Anna Holmes 3 , Shiree Heath 3 , Sophie Van Hees 3 , David Copland, 2,3 1 Centre for Magnetic Resonance, University of Queensland, Brisbane, Queensland, Australia; 2 School of Health and Rehabilitation Sciences, University of Queensland, Australia; 3 UQ Centre for Clinical Research, University of Queensland, Australia A normal elderly cohort was examined with MRI and a lexical access/semantic priming task. The priming effect (semantically related vs unrelated primetarget pairs), and the word (semantic + unrelated response times) versus non-word targets were calculated. These variables were covaried with the individual subjects’ high resolution MRI images, to investigate any possible structural dependencies. Structures of areas associated with attentional and semantic priming networks were significant when compared against non-word responses, and areas of conceptual object knowledge and familiarity when compared with the priming effect.
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