TRADITIONAL POSTER - ismrm

Poster Sessions
hyperexcitation in status epilpticus. SWI directly detect impaired oxygen metabolism caused by increased oxygen demand of the cerebral tissue in pediatric
patients with epileptic seizures. SWI has the possibility to diagnose acute postictal encephalopathy, before cytotoxic edema occurs on DWI.
2055. Changes of Fractional Anisotropy in Ischemic White Matter in Childhood Moyamoya Disease:
Correlation with Perfusion MRI.
Hyeon Tae Jeong 1 , Jinna Kim , Hyeon Seok Choi, Eun Soo Kim, Seung-Koo Lee
1 Department of Radiology, Yonsei University College of Medicine, Seoul, 250 Seongsanno, Seodaemun-gu, Korea, Republic of
The purpose of this study is to evaluate the clinical relevance to FA measurement in white matter suffering from decreased perfusion in moyamoya disease,
through the correlation between FA value and perfusion MRI.
In the areas of chronic hypoperfusion in Moyamoya disease, FA was decreased significantly although overt infarct was not demonstrated. Diffusion tensor
imaging can be used in the assessment of intergrity of white matter suffering from chronic ischemia.
2056. Measurement of Brain Water in Children During and After Treatment for Diabetic Ketoacidosis
Michael H. Buonocore 1 , Sandra L. Wootton-Gorges 2 , Nathan Kuppermann 3 , Ryan Caltagirone, Nicole S.
Glaser
1 Radiology, UC Davis Imaging Research Center, Sacramento, CA, United States; 2 Radiology, UC Davis Medical Center, Sacramento,
CA, United States; 3 Emergency Medicine and Pediatrics, UC Davis Medical Center, Sacramento, CA, United States
The purpose of this study was to measure brain water in children undergoing treatment for DKA to assess cerebral edema. Brain water was measured on a
3T system using FSPGR scans with five different flip angles, followed by non-linear curve fitting to derive proton density (M0) maps, and calibrating
regional M0 map values with the values from 100% water reference vials placed within the imaged volume. Results from seven children suggest that
regional brain water is elevated early in the course of treatment, confirming a degree of cerebral edema. Edema increases during the course of treatment with
fluids and insulin, and then resolves after the child recovers.
2057. Regional Grey-White Matter Volume Abnormalities in Children with Histories of Early Deprivation
Jeong-Won Jeong 1,2 , Michael Behen 1,2 , Piti Sinsoongsud 1,2 , Otto Muzik, 2,3 , Benjamin Wilson 1,2 , Harry T.
Chugani, 2,3
1 Pediatrics and Neurology, Wayne State University, Detroit, MI, United States; 2 PET center, Children's Hospital of Michigan, Detroit,
MI, United States; 3 Pediatrics, Neurology, and Radiology, Wayne State University, Detroit, MI, United States
A previous 18FDG-PET study revealed that children with histories of institutional rearing showed significantly decreased glucose metabolism in neumerous
brain regions. Dysfunction in these regions may result from severe stress of early deprivation. This study presents an atlas-based analysis to assess specific
volumetric changes in predefined brain regions of the children with histories of early deprivation and examines associations between regional findings and
cognitive, socioemotional, and behavioral difficulties that commonly are observed in the orphans. Significant bilateral volume reduction in grey-white matter
was observed in the orphan group. It was highly correlated with their externalizing behavioral deficit and perceptual functioning.
2058. Aberrant Change of Arcuate Fasciculus Geometry in Children with Angelman Syndrome: Diffusion
Tensor MRI Study
Jeong-Won Jeong 1,2 , Senthil Sundaram 1,2 , Benjamin Wilson 1,2 , Harry T. Chugani, 2,3
1 Pediatrics and Neurology, Wayne State University, Detroit, MI, United States; 2 PET center, Children's Hospital of Michigan, Detroit,
MI, United States; 3 Pediatrics, Neurology, and Radiology, Wayne State University, Detroit, MI, United States
Angelman syndrome (AS) is a genetic disorder characterized by mental retardation, speech impairment, and gait apraxia. Speech impairment is universal but
severity differs, which can be characterized by myelination delay or deficits of white matter associated with language production and conception, especially
of arcuate fasciculus (AF) bridging Broca¡¯s and Wernicke¡¯s areas. This study presents new DT-MRI methodology to identify aberrant shapes of arcuate
fibers and quantify abnormal tracts in terms of their geometry. We found that the AF of AS patients have steeper lateral-curvatures cauisng them not to reach
Wernicke¡¯ area and also their FA values were significantly reduced.
2059. DTI Evaluation of Language Tracts in Autistic Patients with and Without Language Impairment
Compared to Typically Developing Children
Lidia M. Nagae 1 , John Dell 1 , Robert A. Zimmerman 1 , Timothy P.L. Roberts 1
1 Radiology, Children's Hospital of Philadelphia, Philadelphia, PA, United States
The superior longitudinal fasciculus (SLF), related to language, was evaluated using diffusion tensor imaging in autistic patients, in particular in a specific
group of autistics patients with language impairment (ASD/+LI), compared to autistic patients without language impairment (ASD/-LI), and typically
developing children and adolescents (TD). Mean diffusivity, along with axial diffusivity were found to be increased in ASD/+LI when compared to TD.
Intermediate values were obtained in ASD/-LI. These findings might reflect reported microstructural abnormalities of the brain, thought to be related to
immature white matter development.
2060. Asymmetric Interhemispheric Fiber Tracts in Patients with Hemimegalencephaly on Difusion Tensor
MRI
Noriko Sato 1 , Tomoyuki Takahashi, Miho Ota, Nakata Yasuhiro, Masayuki Sasaki
1 National Center Hospital of Neurology and Psychiatry, Kodaira, Tokyo, Japan
Asymmetrical fiber tract distributions passing through the corpus callosum in hemimegalencephaly patients.