TRADITIONAL POSTER - ismrm

Poster Sessions
1845. Development and Preliminary Evaluation of a MRI-Guided Transrectal Prostate Intervention
Axel Krieger 1,2 , Sang Eun Song 3 , Nathan Bongjoon Cho 3 , Peter Guion 4 , Iulian Iordachita 1 , Gabor
Fichtinger 5 , Louis L. Whitcomb 1
1 Department of Mechanical Engineering, The Johns Hopkins University, Baltimore, MD, United States; 2 Sentinelle Medical Inc.,
Toronto, Canada; 3 Engineering Research Center, The Johns Hopkins University, Baltimore, MD, United States; 4 National Institute of
Health, Bethesda, MD, United States; 5 School of Computing,, Queen’s University, Kingston, Ontario, Canada
This paper reports the design, development and MRI compatibility evaluation of a transrectal prostate robot for MRI-guided intervention. The robot employs
an automated needle guide with the goal of increasing needle placement accuracy and reducing interventional procedure times. The design of the robot,
employing piezo-ceramic-motor actuated needle guide and manual needle insertion, is reported. Results of a MRI compatibility study show no reduction of
MRI image SNR with the motors disabled and a 40% to 60% reduction with the motors enabled. The addition of RF shielding is shown to significantly
reduce SNR degradation to the presence of the robotic device.
1846. A Device to Facilitate the Performance of Magic Angle Studies on the Wrist and Elbow
Marc Rea 1,2 , Zion Tsz Ho Tse 3 , Haytham Elhawary 3 , Michael Lampérth 2 , Graeme Bydder 4 , Ian Young 5
1 Radiological Sciences Unit, Imperial College London, London, UK, United Kingdom; 2 Mechanical Engineering, Imperial College
London, London, England, United Kingdom; 3 Brigham Womens Hospital, Boston, United States; 4 Radiology, University of California
San Diego, San Diego, CA, United States; 5 Electrical Engineering, Imperial College London, London, United Kingdom
A limb-positioning mechanical platform device was developed for remote orientation of the arm to make use of the magic angle effect for imaging tendons.
The platform is MR-compatible and actuated by rotary air-driven motors. Clinical trials are imminent.
1847. Intra-Procedural MRI-Monitoring of Irreversible Electroporation of Liver Tissues in Rodent Model
Yue Zhang 1,2 , Yang Guo 2 , Ann B. Ragin 2 , Robert J. Lewandowski 2,3 , Guang-yu Yang, 3,4 , Grace M. Nijm 5 ,
Alan V. Sahakian 5 , Reed A. Omary 2,3 , Andrew C. Larson 2,3
1 Bioengineering, University of Illinois at Chicago, Chicago, IL, United States; 2 Radiology, Northwestern University, Chicago, IL,
United States; 3 Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL, United States; 4 Pathology,
Northwestern University, Chicago, IL, United States; 5 Electrical Engineering and Computer Science, Northwestern University,
Evanston, IL, United States
MRI permits immediate depiction of ablated tissue zones for intra-procedural monitoring during irriversible electroporation (IRE) ablation procedures. MRI
monitoring offers the potential to permit intra-procedural optimization of IRE procedures to ensure complete ablation of targeted tissue volumes.
1848. Early Visualization of the Irreversible Electroporation Ablated Tissue Margin by Contrast Enhanced
Imaging in Rodent Model
Yang Guo 1 , Yue Zhang 1,2 , Grace Nijm 3 , Alan Sahakian 3 , Guang-Yu Yang 4 , Reed Omary 1,5 , Andrew
Larson 1,5
1 Department of Radiology, Northwestern University, Chicago, IL, United States; 2 Department of Bioengineering , University of
Illinois at Chicago, Chicago, IL, United States; 3 Department of Electrical Engineering and Computer Science, Northwestern
University, Evanston, IL, United States; 4 Department of Pathology, Northwestern University, Chicago, IL, United States; 5 Department
of Biomedical Engineering , Northwestern University, Chicago, IL, United States
Electroporation involves targeted delivery of electrical pulses to permeabilize cell membranes, either reversible or irreversible. Irreversible electroporation
(IRE), as a new tissue ablation technique, induces tissue necrosis due to permanent cell membrane defects. Assessment of tissue response to IRE may be
critical. For our study, we demonstrate that inversion recovery prepared contrast enhancement imaging, with TI adjusted to null the signal intensity from the
reversible zone, can visualize the IRE ablated tissue margin (differentiating reversible/irreversible zones) to provide an accurate prediction of ablation. This
technique can early detect tissue response to IRE and might be helpful to guide further treatments.
1849. MRI-Guided Focused Ultrasound for Local Delivery of Anti-Aβ Antibodies in a Mouse Model of
Alzheimer’s Disease
Jessica F. Jordao 1,2 , Carlos A. Ayala-Grosso 3,4 , Yuexi Huang 1 , JoAnne McLaurin 2 , Isabelle Aubert, 2,4 ,
Kullervo Hynynen 1,5
1 Imaging Research, Sunnybrook Health Sciences Centre, Toronto, ON, Canada; 2 Laboratory Medicine & Pathobiology, University of
Toronto, Toronto, ON, Canada; 3 Unidad de Biología Molecular, Universidad Central de Venezuela, Los Chaguaramos, Venezuela;
4 Brain Sciences Research, Sunnybrook Health Sciences Centre, Toronto, ON, Canada; 5 Medical Biophysics, University of Toronto,
Toronto, ON, Canada
The use of antibodies to target toxic amyloid-beta peptides (Aβ) in the brain of Alzheimer’s patients has shown promise in clinical trials but still faces some
difficulties. The blood-brain barrier remains a major obstacle; preventing intravenously delivered antibodies from reaching the brain. In this study, we use
transcranial MRI-guided focused ultrasound to efficiently deliver antibodies to the brain of a mouse model of Alzheimer’s disease and evaluate the efficacy
of this treatment. We found that delivery of the antibody is localized to targeted regions and yields a rapid and significant reduction of Aβ plaque load from
a single treatment.