TRADITIONAL POSTER - ismrm

Poster Sessions
2216. Initial Experience with Ferumoxytol Dynamic Susceptibility MRI in Human Brain at 3T and 7T
Jeffrey Moses Njus 1 , Edit Dosa 2 , Seymur Gahramanov 2 , John W. Grinstead 3 , Xin Li 1 , Charles S. Springer,
Jr. 1 , Edward A. Neuwelt 2 , William D. Rooney 1
1 Advanced Imaging Research Center, Oregon Health & Science University, Portland, OR, United States; 2 Department of Neurology,
Oregon Health & Science University, Portland, OR, United States; 3 Siemens Medical Solutions, Portland, OR, United States
MRI DSC techniques offer an efficient way to characterize brain perfusion properties. However, the use of low-molecular weight gadolinium based contrast
agents (Gd) can introduce a significant confound into standard DSC analysis if extravasation is extensive; as often is the case for brain tumors. The purpose
of this study was to investigate the use of an ultra-small paramagnetic iron oxide (USPIO) compound to estimate brain tumor blood volume in human
subjects. To accomplish this goal, DSC acquisitions were performed using both Gd and USPIO based contrast agents in eleven human subjects at 3T and
7T.
Clinical Stroke Imaging: DWI DKI, MTC MRS & Plaque Imaging
Hall B Thursday 13:30-15:30
2217. Identification of Early Onset Strokes Using Multiparametric MRI as a Witness
Ona Wu 1 , Lee H. Schwamm 2 , Priya Garg 1 , Muhammed A. Pervez 2 , Albert J. Yoo 3 , Aurauma Chutinet 2 ,
Robert Irie 1 , Byeongseo Yook 1 , William A. Copen 3 , Pamela W. Schaefer 3 , Aneesh B. Singhal 2 , Karen L.
Furie 2 , Alma Gregory Sorensen 1
1 Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, United States;
2 Department of Neurology, Massachusetts General Hospital; 3 Department of Radiology, Massachusetts General Hospital
Approximately 25% of ischemic stroke patients have unwitnessed strokes and therefore ineligible for on label thrombolytic therapy. We investigated
whether multiparametric MRI can be used for identifying patients who have early stage strokes (