TRADITIONAL POSTER - ismrm

Poster Sessions
is capable of detecting even subtle enhancing tumor free of blood products, thereby enabling the automatic creation of ROIs in a fast and reliable manner
that avoids subjective variability.
2176. Analysis of Brain Tumors and Metastases by Quantitative MT Imaging with BSSFP: Initial
Experiences
Meritxell Garcia 1 , Monika Gloor 2 , Christoph Stippich 1 , Felix Jax 1 , Klaus Scheffler 2 , Oliver Bieri 2
1 Department of Neuroradiology, University of Basel Hospital, Basel, Switzerland; 2 Radiological Physics, University of Basel
Hospital, Basel, Switzerland
The efficacy of quantitative MT (qMT) imaging for characterization of benign and malignant brain lesions is analyzed with balanced steady-state free
precession. Eleven patients with 3 different lesions (4 glioblastoma multiforme, 4 meningeomas and 3 metastases) were investigated on a clinical 1.5T MRscanner.
MT-effects are described in terms of MTR, relaxation times (T1, T2), MT exchange rate (kf) and the macromolecular content (F). Marked
divergences between contrast-enhancing regions, edema and normal-appearing brain were found within and between the different lesions, which might be
attributed to differences in edema, cell infiltration and myelin properties. Thus, qMT-imaging might play a major role in adding information for diagnostic
tumor characterization.
2177. Magnetic Resonance Imaging Contrast of Brain Tumors at 7 Tesla Compared to 3 Tesla
Iris-Melanie Noebauer-Huhmann 1 , Pavol Szomolanyi 1,2 , Claudia Kronnerwetter 1 , Siegfried Trattnig 1
1 MR Centre - High field MR, Department of Radiology, Medical University of Vienna, Vienna, Austria; 2 Department of Imaging
Methods, Institute of Measurement Science, Slovak Academy of Sciences, Bratislava, Slovakia
It is well known that the effect of MR contrast agents is influenced by the magnetic field strength. The aim of the study was to compare the diagnostic
efficacy of a Gadolinium-based MRI contrast agent (gadobenate dimeglumine) in primary brain tumors at 7Tesla versus 3Tesla. Post contrast MP-RAGE
sequences were evaluated by region of interest measurements. At 7Tesla, the tumor-to-brain-contrast after gadolinium administration was significantly
higher (91.4) than at 3Tesla (37.3). Further studies will show if the higher tumor-to-brain-contrast post gadolinium administration at 7Tesla may be
beneficial for tumors with minor contrast agent accumulation, or allow for a dose reduction.
2178. Ultra-High Field MRI of Primary Brain Tumors: Contrast and Resolution
Fernando Emilio Boada 1 , Yongxian Qian 1 , Frank Lieberman 2 , Denise Davis 1 , Ronald Hamilton 3
1 MR Research Center, University of Pittsburgh, Pittsburgh, PA, United States; 2 Neurooncology, University of Pittsburgh, Pittsburgh,
PA, United States; 3 Department of Neuropathology, University of Pittsburgh, Pittsburgh, PA, United States
Imaging of primary brain tumors at Ultra-High Field (UHF) magnetic resonance imaging (MRI) has tremendous appeal due to the expected improvements in
contrast at spatial resolution scales previously unpractical for in vivo human MRI. In this work we demonstrate the use of UHF for evaluating the
microvascular structure of brain tumors and the improvements in signal quantification during sodium MRI
2179. Combined 31 P and 1 H Magnetic Resonance Spectroscopic Imaging of Phosphomono and -Diesters in
Human Brain Tumors at 3T.
Jannie Petra Wijnen 1 , Tom W.J. Scheenen 1 , Arend Heerschap 1
1 Radiology, Radboud University Nijmegen Medical Centre, Nijmegen, Gelderland, Netherlands
We demonstrated the clinical feasibility of combined 1 H and 31 P MRSI with sensitivity enhancement by polarisation transfer of 1 H to 31 P spins of human
brain tumours at 3T to uncover the composition of (phosphorylated)choline and phosphorylated ethanolamine compounds in the membrane. Preliminary
results from 4 patients with different tumour types show potentially important differences among tumours. This opens a window on a detailed view of the
levels of some key metabolites in membrane phospholipid metabolism of human tumours.
2180. Multi-Echo Time Approach for Study of Metabolic Profiles in Brain Tumors at 3T
Changho Choi 1 , Ivan Dimitrov 1,2 , Deborah Douglas 1 , Aditya Patel 1 , Hao Huang 1 , Ralph Deberardinis 3 ,
Juan Pascual 4 , Robert Bachoo 5 , Craig Malloy 1 , Elizabeth Maher 6
1 Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, United States; 2 Philips Medical
Systems, Cleveland, OH, United States; 3 Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX, United States;
4 Neurology, Physiology and Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX, United States; 5 Neurology,
University of Texas Southwestern Medical Center, Dallas, TX, United States; 6 Internal Medicine and Neurology, University of Texas
Southwestern Medical Center, Dallas, TX, United States
Echo time dependence of coupled-spin metabolites following point-resolved spectroscopy (PRESS) at 3T has been investigated with computer simulations.
Three pairs of PRESS subecho times, (TE1, TE2) = (32, 22), (32, 80), and (32, 214) ms, were selected for optimum selectivity of glutamate and glutamine,
and used for in vivo measurements of metabolites in brain tumors. We present preliminary in vivo results that show pronounced abnormalities of metabolic
profiles, including elevated glutamine and glycine in glioblastoma multiforme and differentiation between lipids and lactate in low- and high-grade gliomas.
2181. In Vivo MRI of MR-Labeled Neural Stem Cell Migration to Gliomas
Bensheng Qiu 1 , Daohai Xie 2 , Piotr Walczak 3 , Xubin Li, Jesus Ruiz-Cabello 3 , Satoshi Minoshima, Jeff W.M.
Bulte 3 , Xiaoming Yang
1 University of Washington, Seattle, WA, United States; 2 Radiology, Suzhou University School of Medicine; 3 The Johns Hopkins
University
Neural stem cells (NSC) have been recognized as cellular vehicles for treatment of invasive brain tumors. MRI is a unique non-invasive tool to monitor the
migration of stem cells labeled with MR contrast agents, such as superparamagnetic iron oxide (SPIO) particles. Pervious studies have confirmed that
magnetosonoporation (MSP) can instantly labeled SPIO into stem cells. The aim of this study was to validate the feasibility of MRI of MSP-labeled NSC
migration to gliomas in vivo.